A Study Exploring Two Strategies of Rivaroxaban (JNJ39039039; BAY-59-7939) and One of Oral Vitamin K Antagonist in Patients With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention

PHASE3CompletedINTERVENTIONAL
Enrollment

2,124

Participants

Timeline

Start Date

May 10, 2013

Primary Completion Date

July 28, 2016

Study Completion Date

July 28, 2016

Conditions
Atrial FibrillationPercutaneous Coronary Intervention
Interventions
DRUG

rivaroxaban 2.5 mg

One 2.5 mg tablet twice daily for up to twelve months

DRUG

rivaroxaban 15 mg

One 15 mg tablet once daily for up to twelve months

DRUG

rivaroxaban 10 mg

One 10 mg tablet once daily for up to twelve months

DRUG

aspirin (ASA)

Low-dose aspirin tablet once daily for twelve months

DRUG

vitamin K antagonist (VKA)

Dose-adjusted VKA tablet (target International Normalized Ratio (INR) 2.0 to 3.0) once daily for twelve months

DRUG

clopidogrel

One 75 mg tablet once daily for up to twelve months

DRUG

prasugrel

One 10 mg tablet once daily for up to twelve months

DRUG

ticagrelor

One 90 mg tablet twice daily for up to twelve months

Trial Locations (348)

Unknown

Huntsville

Los Alamitos

Mission Viejo

Oceanside

Riverside

Sacramento

San Francisco

Stockton

Thousand Oaks

Torrance

Colorado Springs

Lakewood

Littleton

Danbury

Washington D.C.

Atlantis

Clearwater

Daytona Beach

Jacksonville

Port Charlotte

Safety Harbor

St. Petersburg

Tallahassee

Tampa

Columbus

Macon

Marietta

Boise

Hazel Crest

Indianapolis

Munster

Hammond

Lake Charles

Slidell

Auburn

Bangor

Baltimore

Detroit

Lansing

Mount Clemens

Petoskey

Ypsilanti

Kansas City

St Louis

Kalispell

Las Vegas

Hackensack

Haddon Heights

New Brunswick

Newark

Ridgewood

Albuquerque

New York

Peekskill

Sanford

Bartlesville

Oklahoma City

Tulsa

Bend

Portland

Abington

Camp Hill

Doylestown

Erie

Philadelphia

Sayre

York

Greenville

Mt. Pleasant

Rapid City

Jackson

Knoxville

Austin

Fort Worth

Humble

Odessa

Plano

Layton

Charlottesville

Manassas

Midlothian

Richmond

Bellevue

Seattle

Milwaukee

Weston

Bahía Blanca

Buenos Aires

C.a.b.a.

Corrientes

Córdoba

La Plata

Resistencia

Rosario

Santa Fe

Vicente López

Chermside

Epping

Hobart

Kogarah

Liverpool

New Lambton

Wollongong

Aalst

Bonheiden

Brasschaat

Bruges

Brussels

Genk

Ghent

Liège

Mechelen

Mol

Roeselare

Turnhout

Belo Horizonte

Blumenau

Brasília

Campina Grande do Sul

Campinas

Curitiba

Marília

Passo Fundo

Porto Alegre

Recife

São José do Rio Preto

São Paulo

Uberlândia

Votuporanga

Blagoevgrad

Burgas

Pazardzhik

Pleven

Plovdiv

Sofia

Varna

Veliko Tarnovo

Edmonton

Maple Ridge

New Westminster

Vancouver

Victoria

St. John's

Greater Sudbury

London

Ottawa

Toronto

Montreal

Québec

Sherbrooke

Chicoutimi

Saint John

Alto

Concepción

Punta Arenas

Santiago

Temuco

Brno

Hradec Králové

Jablonec Na Nisou

Karlovy Vary

Kladno

Litomyšl

Olomouc

Pilsen

Prague

Praha 10 N/A

Slaný

Uherské Hradiště

Aalborg

Copenhagen

Esbjerg

Herlev

Herning

Hvidovre

Koege

Næstved

Odense

Roskilde

Svendborg

Vejle

Besancon Cedex Franche-Comté

Caen

Centrès

Chartres

Lille

Limoges

Marseille

Montfermeil

Nantes

Nîmes

Paris

Pau

Pessac

Poitiers

Toulouse

Bad Friedrichshall

Bad Nauheim

Berlin

Cologne

Dresden

Esslingen am Neckar

Frankfurt am Main

Freiburg im Breisgau

Göttingen

Greifswald

Hamburg

Heidelberg

Limburg

Mannheim

Ulm

Witten

George Town

Johor Bahru

Kajang

Kuala Lumpur

Aguascalientes

Guadalajara

León

México

Pachuca

Puebla City

Querétaro

Villahermosa

Zapopan

's-Hertogenbosch

Alkmaar

Amsterdam

Amsterdam-Zuidoost

Breda

Delft

Gorinchem

Leiden

Maastricht

Nieuwegein

Sneek

Uden

Będzin

Bielsko-Biala

Chrzanów

Gdynia

Grodzisk Mazowiecki

Katowice

Krakow

Lodz

Mielec

Nowy Targ

Ostrowiec Świętokrzyski

Oświęcim

Płock

Rzeszow Poland

Starachowice

Starogard Gdański

Szczecin

Torun

Tychy

Ustroń

Warsaw

Zamość

Bucharest

Cluj-Napoca

Târgu Mureş

Tg Mures

Arkhangelsk

Barnaul

Chita

Kemerovo

Krasnodar

Krasnoyarsk

Moscow

Nizhny Novgorod

Perm

Rostov-on-Don

Saint Petersburg

Samara

Saratov

Syktyvkar

Tyumen

Yekaterinburg

Cape Town

Centurion

Linksfield West, Johannesburg

Somerset West

Busan

Daejeon

Gyeonggi-do

Incheon

Seongnam

Seoul

Suwon

Uijeongbu-si

Wŏnju

Falun

Gothenburg

Jönköping

Lund

Malmo

Örebro

Stockholm

Umeå

Kaohsiung City

Taichung

Tainan City

Taipei

Taoyuan District

Ankara

Antalya

Bursa

Gaziantep

Istanbul

Istanbul Nap

Izmir

Kayseri

Sivas

Cherkassy

Dnipro

Ivano-Frankivsk

Kharkiv

Khemelnitskiy

Kyiv

Lviv

Odesa

Rivne

Uzhhorod

Zaporizhzhya

Bath

Birmingham

Blackburn

Bradford

Clydebank

Cottingham

Coventry

Dorchester

Dundee

Edinburgh

Exeter

Hampshire

Harrow

High Wycombe

London

Middlesbrough

Norwich

Nottingham

Plymouth

Portsmouth

Torquay

Truro

Worcester

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bayer

INDUSTRY

lead

Janssen Scientific Affairs, LLC

INDUSTRY