Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

144

Participants

Timeline

Start Date

August 8, 2013

Primary Completion Date

May 26, 2021

Study Completion Date

December 31, 2025

Conditions
GastrinomaGlucagonomaInsulinomaIslet Cell CarcinomaPancreatic Polypeptide TumorRecurrent Islet Cell CarcinomaSomatostatinoma
Interventions
DRUG

temozolomide

Given PO

DRUG

capecitabine

Given PO

Trial Locations (323)

10461

Montefiore Medical Center-Weiler Division, The Bronx

12010

New York Oncology Hematology PC - Amsterdam, Amsterdam

12110

New York Oncology Hematology PC - Latham, Latham

12148

New York Oncology Hematology PC - Rexford, Rexford

12180

New York Oncology Hematology PC - Troy, Troy

12206

New York Oncology Hematology PC - Albany, Albany

12208

New York Oncology Hematology PC -Albany Medical Center, Albany

12534

New York Oncology Hematology PC-Hudson, Hudson

14642

University of Rochester, Rochester

16801

Geisinger Medical Group, State College

17837

Geisinger Medical Oncology at Evangelical Community Hospital, Lewisburg

17901

Geisinger Medical Oncology-Pottsville, Pottsville

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18711

Geisinger Wyoming Valley, Wilkes-Barre

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

19611

Reading Hospital, West Reading

19713

Christiana Gynecologic Oncology LLC, Newark

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

Regional Hematology and Oncology PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

Beebe Medical Center, Lewes

19971

Beebe Health Campus, Rehoboth Beach

19973

Nanticoke Memorial Hospital, Seaford

22401

Fredericksburg Oncology Inc, Fredericksburg

28501

Kinston Medical Specialists PA, Kinston

28677

Iredell Memorial Hospital, Statesville

29605

Greenville Health System Cancer Institute-Butternut, Greenville

29615

Greenville Health System Cancer Institute/Greenville CCOP, Greenville

29650

Greenville Health System Cancer Institute-Greer, Greer

32207

Edna Williams Cancer Center at the Baptist Cancer Institute, Jacksonville

32803

Florida Hospital, Orlando

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33612

H. Lee Moffitt Cancer Center and Research Institute, Tampa

41017

Oncology Hematology Care Incorporated, Crestview Hills

43015

Delaware Health Center-Grady Cancer Center, Delaware

Delaware Radiation Oncology, Delaware

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

Newark Radiation Oncology, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

Lancaster Radiation Oncology, Lancaster

43210

Ohio State University Medical Center, Columbus

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

43215

Columbus CCOP, Columbus

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43402

Toledo Clinic Cancer Centers-Bowling Green, Bowling Green

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee

43560

Flower Hospital, Sylvania

43567

Fulton County Health Center, Wauseon

43606

The Toledo Hospital/Toledo Children's Hospital, Toledo

43608

Saint Vincent Mercy Medical Center, Toledo

43614

University of Toledo, Toledo

43616

Saint Charles Hospital, Oregon

Toledo Clinic Cancer Centers-Oregon, Oregon

43617

Toledo Community Hospital Oncology Program CCOP, Toledo

43623

Mercy Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

43701

Genesis HealthCare System, Zanesville

44035

Hematology Oncology Center Incorporated, Elyria

Mercy Cancer Center-Elyria, Elyria

44106

Case Western Reserve University, Cleveland

44122

Cleveland Clinic Cancer Center Beachwood, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44131

Cleveland Clinic Cancer Center Independence, Independence

44136

Cleveland Clinic Cancer Center-Strongsville, Strongsville

44195

Cleveland Clinic Foundation, Cleveland

44307

Akron General Medical Center, Akron

44870

North Coast Cancer Care, Sandusky

44883

Mercy Hospital of Tiffin, Tiffin

45014

Oncology Hematology Care Inc, Fairfield

45219

Oncology and Hematology Care Incorporated, Cincinnati

45230

Oncology Hematology Care Inc - Anderson, Cincinnati

45236

Oncology Hematology Care Inc - Kenwood, Cincinnati

45242

Oncology and Hematology Care Inc - Blue Ash, Cincinnati

45248

Oncology Hematology Care Inc - Western Hills, Cincinnati

45267

University of Cincinnati, Cincinnati

45331

Wayne Hospital, Greenville

45373

Upper Valley Medical Center, Troy

45385

Greene Memorial Hospital, Xenia

45405

Grandview Hospital, Dayton

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Samaritan North Health Center, Dayton

45420

Dayton CCOP, Dayton

45429

Kettering Medical Center, Kettering

45505

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45714

Strecker Cancer Center-Belpre, Belpre

45750

Marietta Memorial Hospital, Marietta

45801

Saint Rita's Medical Center, Lima

45804

Lima Memorial Hospital, Lima

45840

Blanchard Valley Hospital, Findlay

46237

Franciscan Saint Francis Health-Indianapolis, Indianapolis

47374

Reid Hospital and Health Care Services, Richmond

48060

Saint Joseph Mercy Port Huron, Port Huron

48093

Saint John Macomb-Oakland Hospital, Warren

48106

Michigan Cancer Research Consortium Community Clinical Oncology Program, Ann Arbor

48109

University of Michigan University Hospital, Ann Arbor

48124

Oakwood Hospital, Dearborn

48154

Saint Mary Mercy Hospital, Livonia

48162

Community Cancer Center of Monroe, Monroe

Mercy Memorial Hospital, Monroe

48236

Saint John Hospital and Medical Center, Detroit

48502

Hurley Medical Center, Flint

48503

Genesys Hurley Cancer Institute, Flint

48601

Saint Mary's of Michigan, Saginaw

48912

Sparrow Hospital, Lansing

49001

Borgess Medical Center, Kalamazoo

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49201

Allegiance Health, Jackson

49221

Bixby Medical Center, Adrian

Hickman Cancer Center, Adrian

50010

Mary Greeley Medical Center, Ames

McFarland Clinic PC-William R Bliss Cancer Center, Ames

50036

McFarland Clinic PC-Boone, Boone

50129

McFarland Clinic PC-Jefferson, Jefferson

50158

McFarland Clinic PC-Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Iowa Oncology Research Association CCOP, Des Moines

Medical Oncology and Hematology Associates-Des Moines, Des Moines

50314

Medical Oncology and Hematology Associates-Laurel, Des Moines

Mercy Medical Center - Des Moines, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

Mercy Cancer Center-West Lakes, Clive

51101

Siouxland Hematology Oncology Associates, Sioux City

51104

Mercy Medical Center-Sioux City, Sioux City

Saint Luke's Regional Medical Center, Sioux City

52722

Constantinou, Costas L MD (UIA Investigator), Bettendorf

53226

Froedtert and the Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

54017

Cancer Center of Western Wisconsin, New Richmond

54601

Gundersen Lutheran, La Crosse

55082

Lakeview Hospital, Stillwater

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology and Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro-Minnesota CCOP, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview-Southdale Hospital, Edina

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

60035

Hematology Oncology Associates of Illinois-Highland Park, Highland Park

60048

North Shore Hematology Oncology, Libertyville

60076

Hematology Oncology Associates of Illinois - Skokie, Skokie

60153

Loyola University Medical Center, Maywood

60521

Hinsdale Hematology Oncology Associates Incorporated, Hinsdale

60611

Northwestern University, Chicago

60612

University of Illinois, Chicago

60714

Illinois Cancer Specialists-Niles, Niles

60901

Presence Saint Mary's Hospital, Kankakee

61107

SwedishAmerican Regional Cancer Center/ACT, Rockford

61265

Garneau, Stewart C MD (UIA Investigator), Moline

Porubcin, Michael MD (UIA Investigator), Moline

Spector, David MD (UIA Investigator), Moline

Trinity Medical Center, Moline

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

Ottawa Regional Hospital and Healthcare Center, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare Galesburg, Galesburg

Illinois CancerCare-Galesburg Cottage Plaza Office, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61462

Illinois CancerCare-Monmouth, Monmouth

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Pekin Cancer Treatment Center, Pekin

61603

Illinois CancerCare-Pekin, Pekin

Methodist Medical Center of Illinois, Peoria

61614

Proctor Hospital, Peoria

61615

Illinois CancerCare-Peoria, Peoria

Illinois Oncology Research Association CCOP, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

Illinois CancerCare-Bloomington, Bloomington

Saint Joseph Medical Center, Bloomington

61761

Community Cancer Center Foundation, Normal

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Center of Decatur, Decatur

Decatur Memorial Hospital, Decatur

62801

Centralia Oncology Clinic, Centralia

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Saint John's Mercy Medical Center, St Louis

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

65109

Capital Region Medical Center-Goldschmidt Cancer Center, Jefferson City

65401

Phelps County Regional Medical Center, Rolla

Saint John's Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center-Carrie J Babb Cancer Center, Bolivar

65616

CoxHealth Cancer Center, Branson

65802

Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield, Springfield

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66502

Cancer Center of Kansas-Manhattan, Manhattan

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Cancer Center of Kansas - Main Office, Wichita

Via Christi Regional Medical Center, Wichita

Wichita CCOP, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67801

Cancer Center of Kansas - Dodge City, Dodge City

67901

Cancer Center of Kansas-Liberal, Liberal

68114

Nebraska Methodist Hospital, Omaha

70121

Ochsner Medical Center Jefferson, New Orleans

70809

Ochsner Health Center-Summa, Baton Rouge

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Tulsa Cancer Institute, Tulsa

83706

Saint Alphonsus Regional Medical Center, Boise

89106

Nevada Cancer Research Foundation CCOP, Las Vegas

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90033

University of Southern California/Norris Cancer Center, Los Angeles

90034

Kaiser Permanente-West Los Angeles, Los Angeles

90048

Cedars-Sinai Medical Center, Los Angeles

90706

Kaiser Foundation Hospital, Bellflower

90710

Kaiser Permanente - Harbor City, Harbor City

91367

Kaiser Permanente, Woodland Hills

91402

Kaiser Permanente - Panorama City, Panorama City

91706

Kaiser Permanente Medical Group - Baldwin Park, Baldwin Park

92069

Kaiser Permanente Health Care, San Marcos

92120

Kaiser Permanente at San Diego, San Diego

Kaiser Permanente, San Diego

92335

Kaiser Permanente Hospital, Fontana

92505

Kaiser Permanente Medical Center, Riverside

92618

Southern California Permanente Medical Group, Irvine

92807

Kaiser Anaheim Medical Center, Anaheim

92868

University of California Medical Center At Irvine-Orange Campus, Orange

93720

Kaiser Permanente, Fresno

94010

Mills - Peninsula Hospitals, Burlingame

94063

Kaiser Permanente-Redwood City, Redwood City

94080

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

UCSF-Mount Zion, San Francisco

94118

California Pacific Medical Center, San Francisco

94305

Stanford University Hospitals and Clinics, Stanford

94531

Kaiser Permanente-Deer Valley Medical Center, Antioch

94538

Kaiser Permanente, Fremont, Fremont

94545

Kaiser Permanente, Hayward, Hayward

94589

Kaiser Permanente-Vallejo, Vallejo

Sutter Solano Medical Center, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

94801

Kaiser Permanente-Richmond, Richmond

94903

Kaiser Permanente-San Rafael, San Rafael

94945

Sutter Cancer Research Consortium, Novato

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95210

Kaiser Permanente-Stockton, Stockton

95356

Kaiser Permanente-Modesto, Modesto

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

Sutter Pacific Medical Foundation, Santa Rosa

95661

Kaiser Permanente-Roseville, Roseville

95688

Kaiser Permanente Medical Center-Vacaville, Vacaville

95823

Kaiser Permanente-South Sacramento, Sacramento

95825

Kaiser Permanente - Sacramento, Sacramento

96701

Oncare Hawaii Inc-Pali Momi, ‘Aiea

Pali Momi Medical Center, ‘Aiea

96734

Castle Medical Center, Kailua

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

Oncare Hawaii Inc-POB II, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii, Honolulu

96817

Oncare Hawaii Inc-Kuakini, Honolulu

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

06105

Saint Francis Hospital and Medical Center, Hartford

06457

Middlesex Hospital, Middletown

96817-3169

OnCare Hawaii-Liliha, Honolulu

62781-0001

Memorial Medical Center, Springfield

50266-7700

Methodist West Hospital, West Des Moines

02118

Boston Medical Center, Boston

01805

Lahey Hospital and Medical Center, Burlington

48106-0995

Saint Joseph Mercy Hospital, Ann Arbor

48341-2985

Saint Joseph Mercy Oakland, Pontiac

08103

Cooper Hospital University Medical Center, Camden

08060

Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County, Mount Holly

08043

Virtua West Jersey Hospital Voorhees, Voorhees Township

10467-2490

Montefiore Medical Center, The Bronx

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

17822-2001

Geisinger Medical Center, Danville

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

37232-6838

Vanderbilt Cancer Center, Nashville

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

ECOG-ACRIN Cancer Research Group

NETWORK

NCT01824875 - Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors | Biotech Hunter | Biotech Hunter