59
Participants
Start Date
November 4, 2013
Primary Completion Date
June 4, 2018
Study Completion Date
June 4, 2018
Radiation Therapy
30 once-daily 2 Gy fractions over 6 weeks totaling 60 Gy of intensity-modulated radiation therapy (IMRT) or 3-dimensional conformal radiation therapy (3D-CRT).
Carboplatin
"Concurrent: AUC=2, IV, days 1, 8, 14, 22, 29, and 36 of radiation therapy. For patients receiving either erlotinib or crizotinib, carboplatin will begin 2 weeks after erlotinib or crizotinib, as applicable.~Consolidation: 4-6 weeks after completion of RT, AUC=6, IV, days 1 and 22."
Cisplatin
50 mg/m2, IV (intravenous), on days 1 and 8 of two 4-week cycles concurrent with radiation therapy. For patients receiving either erlotinib or crizotinib, cisplatin will begin 2 weeks after the completion of erlotinib or crizotinib, as applicable.
Crizotinib
250 mg, orally, twice daily for four 3-week cycles (12 weeks in total)
Erlotinib
150 mg, orally, once daily for four 3-week cycles (12 weeks in total)
Etoposide
50 mg/m2, IV, on days 1 and 8 of two 4-week cycles concurrent with radiation therapy. For patients receiving either erlotinib or crizotinib, etoposide will begin 2 weeks after the completion of erlotinib or crizotinib, as applicable.
Paclitaxel
"Concurrent: 45 mg/m2, IV, days 1, 8, 14, 22, 29, and 36 of radiation therapy. For patients receiving either erlotinib or crizotinib, carboplatin will begin 2 weeks after erlotinib or crizotinib, as applicable.~Consolidation: 4-6 weeks after completion of RT, 200 mg/m2, IV, days 1 and 22."
Mount Sinai Union Square, New York
Mount Sinai Hospital, New York
Weill Medical College of Cornell University, New York
Staten Island University Hospital, Staten Island
State University of New York Upstate Medical University, Syracuse
Mary Imogene Bassett Hospital, Cooperstown
University of Rochester, Rochester
Geisinger Medical Center, Danville
Guthrie Medical Group PC-Robert Packer Hospital, Sayre
Bryn Mawr Hospital, Bryn Mawr
Lankenau Medical Center, Wynnewood
Fox Chase Cancer Center, Philadelphia
Paoli Memorial Hospital, Paoli
Christiana Care Health System-Christiana Hospital, Newark
University of Maryland/Greenebaum Cancer Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
Edwards Comprehensive Cancer Center, Huntington
Wake Forest University Health Sciences, Winston-Salem
FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst
Cancer Care of Western North Carolina, Asheville
Mission Hospital-Memorial Campus, Asheville
Spartanburg Medical Center, Spartanburg
Greenville Health System Cancer Institute-Spartanburg, Spartanburg
Medical University of South Carolina, Charleston
Greenville Health System Cancer Institute-Faris, Greenville
Greenville Health System Cancer Institute-Eastside, Greenville
Self Regional Healthcare, Greenwood
Greenville Health System Cancer Institute-Greer, Greer
Gibbs Cancer Center-Pelham, Greer
Greenville Health System Cancer Institute-Seneca, Seneca
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Northeast Georgia Medical Center-Gainesville, Gainesville
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
Integrated Community Oncology Network-Flager Cancer Center, Saint Augustine
21st Century Oncology-Palatka, Palatka
Baptist MD Anderson Cancer Center, Jacksonville
Baptist Medical Center South, Jacksonville
UF Cancer Center at Orlando Health, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
Memorial Hospital West, Pembroke Pines
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
Moffitt Cancer Center, Tampa
Robert and Carol Weissman Cancer Center at Martin Health, Stuart
University of Alabama at Birmingham Cancer Center, Birmingham
Ohio State University Comprehensive Cancer Center, Columbus
Grant Medical Center, Columbus
The Mark H Zangmeister Center, Columbus
Mercy Cancer Center-Elyria, Elyria
Case Western Reserve University, Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
Cleveland Clinic Cancer Center Independence, Independence
Cleveland Clinic Cancer Center Strongsville, Strongsville
Cleveland Clinic Foundation, Cleveland
Summa Barberton Hospital, Barberton
Summa Akron City Hospital/Cooper Cancer Center, Akron
Cleveland Clinic Akron General, Akron
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster
North Coast Cancer Care, Sandusky
Adena Regional Medical Center, Chillicothe
Saint Vincent Anderson Regional Hospital/Cancer Center, Anderson
Radiation Oncology Associates PC, Fort Wayne
Parkview Hospital Randallia, Fort Wayne
Saint Joseph Mercy Hospital, Ann Arbor
Beaumont Hospital-Dearborn, Dearborn
Saint Mary Mercy Hospital, Livonia
Saint Joseph Mercy Oakland, Pontiac
Saint Mary's of Michigan, Saginaw
West Michigan Cancer Center, Kalamazoo
Mercy Health Saint Mary's, Grand Rapids
Spectrum Health at Butterworth Campus, Grand Rapids
McFarland Clinic PC - Ames, Ames
Siouxland Regional Cancer Center, Sioux City
Saint Luke's Hospital, Cedar Rapids
Mercy Hospital, Cedar Rapids
Community Memorial Hospital, Menomonee Falls
The Alyce and Elmore Kraemer Cancer Care Center, West Bend
Columbia Saint Mary's Hospital - Ozaukee, Mequon
ProHealth Waukesha Memorial Hospital, Waukesha
Columbia Saint Mary's Water Tower Medical Commons, Milwaukee
Froedtert and the Medical College of Wisconsin, Milwaukee
Cancer Center of Western Wisconsin, New Richmond
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay
Regions Hospital, Saint Paul
United Hospital, Saint Paul
Abbott-Northwestern Hospital, Minneapolis
Hennepin County Medical Center, Minneapolis
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Unity Hospital, Fridley
Mercy Hospital, Coon Rapids
Miller-Dwan Hospital, Duluth
Mayo Clinic, Rochester
Rice Memorial Hospital, Willmar
AMITA Health Alexian Brothers Medical Center, Elk Grove Village
Elmhurst Memorial Hospital, Elmhurst
Loyola University Medical Center, Maywood
AMITA Health Cancer Institute and Outpatient Center, Hinsdale
Edward Hospital/Cancer Center, Naperville
Edward Hospital/Cancer Center?Plainfield, Plainfield
Northwestern University, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
SwedishAmerican Regional Cancer Center/ACT, Rockford
Crossroads Cancer Center, Effingham
Decatur Memorial Hospital, Decatur
Memorial Medical Center, Springfield
Washington University School of Medicine, St Louis
Missouri Baptist Medical Center, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
Southeast Cancer Center, Cape Girardeau
Saint Luke's Hospital of Kansas City, Kansas City
Delbert Day Cancer Institute at PCRMC, Rolla
CoxHealth South Hospital, Springfield
Nebraska Methodist Hospital, Omaha
University of Oklahoma Health Sciences Center, Oklahoma City
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
M D Anderson Cancer Center, Houston
The Don and Sybil Harrington Cancer Center, Amarillo
Covenant Medical Center-Lakeside, Lubbock
University of Colorado Hospital, Aurora
Rocky Mountain Cancer Centers-Boulder, Boulder
Poudre Valley Hospital, Fort Collins
McKee Medical Center, Loveland
North Colorado Medical Center, Greeley
Penrose-Saint Francis Healthcare, Colorado Springs
UCHealth Memorial Hospital Central, Colorado Springs
Saint Alphonsus Cancer Care Center-Boise, Boise
Intermountain Medical Center, Murray
Dixie Medical Center Regional Cancer Center, St. George
Banner MD Anderson Cancer Center, Gilbert
Mayo Clinic in Arizona, Scottsdale
University of New Mexico Cancer Center, Albuquerque
UC San Diego Moores Cancer Center, La Jolla
AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
UCSF Medical Center-Mount Zion, San Francisco
Stanford Cancer Institute Palo Alto, Palo Alto
Saint Helena Hospital, St. Helena
Mercy UC Davis Cancer Center, Merced
University of California Davis Comprehensive Cancer Center, Sacramento
Fremont - Rideout Cancer Center, Marysville
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee
Queen's Medical Center, Honolulu
The Cancer Center of Hawaii-Liliha, Honolulu
Clackamas Radiation Oncology Center, Clackamas
Legacy Mount Hood Medical Center, Gresham
Legacy Good Samaritan Hospital and Medical Center, Portland
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
Kaiser Permanente Northwest, Portland
Salem Hospital, Salem
PeaceHealth Saint John Medical Center, Longview
PeaceHealth Southwest Medical Center, Vancouver
Providence Alaska Medical Center, Anchorage
Hartford Hospital, Hartford
The Hospital of Central Connecticut, New Britain
Harold Alfond Center for Cancer Care, Augusta
Maine Medical Center- Scarborough Campus, Scarborough
Tufts Medical Center, Boston
Beth Israel Deaconess Medical Center, Boston
Dana-Farber Cancer Institute, Boston
Lahey Hospital and Medical Center, Burlington
Lowell General Hospital, Lowell
Concord Hospital, Concord
Elliot Hospital, Manchester
Virtua Memorial, Mount Holly
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Rutgers Cancer Institute of New Jersey, New Brunswick
Community Medical Center, Toms River
Virtua Voorhees, Voorhees Township
Collaborators (1)
NRG Oncology
OTHER
National Cancer Institute (NCI)
NIH