GLOBAL LEADERS: A Clinical Study Comparing Two Forms of Anti-platelet Therapy After Stent Implantation

PHASE3CompletedINTERVENTIONAL
Enrollment

15,991

Participants

Timeline

Start Date

July 1, 2013

Primary Completion Date

November 9, 2015

Study Completion Date

April 26, 2018

Conditions
Coronary Artery Disease (CAD)
Interventions
DRUG

Ticagrelor

Comparison of 1 month of ticagrelor and aspirin followed by 23 months of ticagrelor monotherapy versus 12 months of standard dual anti platelet therapy (DAPT) followed by aspirin monotherapy.

DRUG

Acetylsalicylic Acid

Comparison of 1 month of ticagrelor and aspirin followed by 23 months of ticagrelor monotherapy versus 12 months of standard dual anti platelet therapy (DAPT) followed by aspirin monotherapy

DRUG

Clopidogrel

"Active Comparator: Reference treatment strategy Acute Coronary Syndrome (ACS) patients incl. unstable angina (UA) patients: ASA and Brilique(ticagrelor) for 12 months followed by 12 months of ASA monotherapy.~Stable Coronary Artery Disease (CAD) patients: ASA and clopidogrel for 12 months followed by 12 months of ASA monotherapy"

Trial Locations (130)

Unknown

Research centre Brisbane, 6101, Brisbane

Research centre Melbourne, 6104, Melbourne

Research centre Melbourne, 6105, Melbourne

Research centre Graz, 4305, Graz

Rsearch centre Innsbruck, 4303, Innsbruck

Research centre Linz, 4304, Linz

Research centre Vienna, 4301, Vienna

Research centre Vienna, 4302, Vienna

Research centre Aalst, 3201, Aalst

Research centre Aalst, 3206, Aalst

Research centre Bonheiden, 3204, Bonheiden

Research centre Charleroi, 3202, Charleroi

Research centre Genk, 3205, Genk

Research centre Hasselt, 3203, Hasselt

Research centre Rio de Janeiro, 5503, Rio de Janeiro

Research centre Rio de Janeiro, 5504, Rio de Janeiro

Research centre Sao Paulo, 5501, São Paulo

Research centre Sao Paulo, 5502, São Paulo

Research centre Uberlândia, 5505, Uberlândia

Research centre Burgas, 9902, Burgas

Research centre Plovdiv, 9905, Plovdiv

Research centre Sofia, 9901, Sofia

Research centre Sofia, 9903, Sofia

Research centre Sofia, 9904, Sofia

Research centre Sofia, 9907, Sofia

Research centre Sofia, 9908, Sofia

Research centre Varna, 9906, Varna

Research centre Newmarket, 1003, Newmarket

Research centre Quebec, 1001, Québec

Research centre Copenhagen, 4501, Copenhagen

Research centre Roskilde, 4503, Roskilde

Research centre Aix en Provence, 3311, Aix-en-Provence

Research centre Caen, 3308, Caen

Research centre Caen, 3309, Caen

Research centre Clermont-Ferrand, 3303, Clermont-Ferrand

Research centre Dijon, 3313, Dijon

Research centre Grenoble, 3312, Grenoble

Research centre Lyon, 3316, Lyon

Research centre Nancy, 3314, Nancy

Research centre Paris, 3301, Paris

Research centre Paris, 3305, Paris

Research centre Rouen, 3307, Rouen

Research centre Saint Etienne, 3310, Saint-Etienne

Research centre Toulouse, 3302, Toulouse

Research centre Bad Krozingen, 4904, Bad Krozingen

Research centre Bad Nauheim, 4902, Bad Nauheim

Research centre Berlin, 4918, Berlin

Research centre Bonn, 4911, Bonn

Research centre Dresden, 4908, Dresden

Research centre Essen, 4903, Essen

Research centre Fulda, 4905, Fulda

Research centre Giessen 4901, Giessen

Research centre Göttingen, 4907, Göttingen

Research centre Landshut, 4909, Landshut

Research centre Lubeck, 4917, Lübeck

Research centre Mainz, 4910, Mainz

Research centre Mannheim, 4912, Mannheim

Research centre Mönchengladbach, 4915, Mönchengladbach

Research centre Neuss, 4916, Neuss

Research centre Tubingen, 4914, Tübingen

Research centre Villingen - Schwenningen, 4919, Villingen-Schwenningen

Research centre Balatonfüred, 3608, Balatonfüred

Research centre Budapest, 3602, Budapest

Research centre Budapest, 3603, Budapest

Research centre Debrecen, 3607, Debrecen

Research centre Gyula, 3606, Gyula

Research centre Nyíregyháza, 3605, Nyíregyháza

Research centre Pécs, 3604, Pécs

Research centre szeged, 3601, Szeged

Research centre Arezzo, 3902, Arezzo

Research centre Brescia, 3912, Brescia

Research centre Ferrara, 3905, Ferrara

Research centre Milano, 3901, Milan

Research centre Pavia, 3903, Pavia

Research centre Terni, 3909, Terni

Research centre Alkmaar, 3106, Alkmaar

OLVG Research centre Amsterdam, 3104, Amsterdam

UMCG Groningen, 3108, Groningen

Research centre Leeuwarden, 3102, Leeuwarden

Research centre Nieuwegein, 3107, Nieuwegein

Research centre Nijmegen, 3105, Nijmegen

EMC Rotterdam, 3101, Rotterdam

Maasstad Rotterdam, 3103, Rotterdam

Research centre Tilburg, 3109, Tilburg

Research centre Chrzanow, 4802, Chrzanów

Research centre Dabrowa Gornicza, 4801, Dąbrowa Górnicza

Research centre Kedzierzyn-Kozle, 4805, Kędzierzyn-Koźle

Research centre Krakov, 4807, Krakow

Research centre Mielec, 4809, Mielec

Research centre Nysa, 4808, Nysa

Research centre Ustroń, 4803, Ustroń

Research centre Gaia, 3501, Gaia

Research centre Lisbon, 3503, Lisbon

Research centre Lisbon, 3504, Lisbon

Research centre Lisbon, 3505, Lisbon

Research centre Singapore, 6501, Singapore

Research centre Singapore, 6502, Singapore

Research centre Barcelona, 3401, Barcelona

Research centre Barcelona, 3403, Barcelona

Research centre Barcelona, 3405, Barcelona

Research centre Huelva, 3408, Huelva

Research centre Madrid 3410, Madrid

Research centre Madrid, 3402, Madrid

Research centre Madrid, 3407, Madrid

Research centre Madrid, 3409, Madrid

Research centre Vigo, 3404, Vigo

Research centre Bern, 4106, Bern

Research centre Bern, 4107, Bern

Research centre Geneva, 4101, Geneva

Research centre Lausanne, 4104, Lausanne

Research centre Liestal, 4108, Liestal

Research centre Lugano, 4105, Lugano

Research centre Belfast, 4420, Belfast

Research Centre Belfast, 4423, Belfast

Research centre Blackburn, 4404, Blackburn

Research centre Blackpool, 4408, Blackpool

Research centre Bournemouth, 4418, Bournemouth

Research centre Brighton, 4405, Brighton

Research centre Cambridge, 4417, Cambridge

Research centre Cardiff, 4402, Cardiff

Research centre Glasgow, 4407, Glasgow

Research centre Leicester, 4421, Leicester

Research centre Liverpool, 4001, Liverpool

Research centre Manchester, 4403, Manchester

Research centre Manchester, 4406, Manchester

Research centre Newcastle, 4413, Newcastle

Research centre Rhyl, 4414, Rhyl

Research centre Southampton, 4415, Southampton

Research centre Stevenage, 4412, Stevenage

Research centre Wolverhampton, 4422, Wolverhampton

All Listed Sponsors
collaborator

Biosensors International

OTHER

collaborator

AstraZeneca

INDUSTRY

collaborator

The Medicines Company

INDUSTRY

lead

ECRI bv

INDUSTRY