A Long-term Extension Study of PCI-32765 (Ibrutinib)

PHASE3RecruitingINTERVENTIONAL
Enrollment

700

Participants

Timeline

Start Date

September 9, 2013

Primary Completion Date

December 31, 2026

Study Completion Date

January 29, 2027

Conditions
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaMantle Cell LymphomaFollicular LymphomaDiffuse Large B-cell LymphomaWaldenstrom MacroglobulinemiaChronic Graft Versus Host Disease
Interventions
DRUG

Ibrutinib

Ibrutinib will be given orally as capsules, once daily continuously, according to the current dosing regimen established in the parent ibrutinib clinical study (560 mg, 420 mg, 280 mg, or 140 mg), at approximately the same time each day.

Trial Locations (174)

500

COMPLETED

Changhua Cristian Hospital, Changhua County

1083

COMPLETED

Semmelweis Egyetem, I. Belgyogyaszati Klinika, Budapest

1200

RECRUITING

UCL - Saint Luc, Brussels

1600

COMPLETED

Instituto Portugues de Oncologia, Lisbon

2076

RECRUITING

Adventist Health Care Limited trading as San Clinical Trials Unit, Wahroonga

2139

COMPLETED

Concord Hospital, Concord

2650

COMPLETED

UZA, Antwerp

3000

COMPLETED

Peter MacCallum Cancer Institute, Melbourne

RECRUITING

UZ Leuven Gasthuisberg, Leuven

3058

COMPLETED

John Fawkner Cancer Trial Centre, Coburg

3084

COMPLETED

Austin Health, Heidelberg

3181

COMPLETED

Alfred Hospital, Prahran

5000

ACTIVE_NOT_RECRUITING

Royal Adelaide Hospital, Adelaide

5530

RECRUITING

UCL Mont-Godinne, Yvoir

6590

COMPLETED

Ankara University, Ankara

6725

COMPLETED

Szegedi Tudomanyegyetem II. Belgyogyaszati Klinika, Szeged

6847

COMPLETED

Royal Perth Hospital, Perth

8000

COMPLETED

A.Z. Sint Jan, Bruges

9000

COMPLETED

UZ Gent - departement oncologie, Ghent

10021

COMPLETED

Weill Medical College of Cornell University, New York

10065

COMPLETED

Memorial Sloan-Kettering Cancer Center, New York

10126

COMPLETED

A.O.Citta della Salute e della Scienza di Torino, Torino

10408

COMPLETED

National Cancer Center, Goyang-si

13589

COMPLETED

Vivantes Klinikum Spandau-Klinik f. Innere Medizin Hämatologie/Onkologie/Gastroenterologie - Germany, Berlin

18009

ACTIVE_NOT_RECRUITING

Communal Nonprofit Enterprise 'Cherkasy Regional Oncology Dispensary Of Cherkasy Regional Council', Cherkasy

19104

COMPLETED

University of Pennsylvania Medical Center, Philadelphia

20162

COMPLETED

ASST Grande Ospedale Metropolitano Niguarda, Milan

21018

COMPLETED

Vinnytsya Regional Clinical Hospital named after M.I.Pirogov, Vinnitsa

22185

COMPLETED

Skanes universitetssjukhus, Lund

22908

COMPLETED

University of Virginia, Charlottesville

26506

COMPLETED

West Virginia University, Morgantown

27534

COMPLETED

Southeastern Medical Oncology Center, Goldsboro

28006

COMPLETED

Hosp. Univ. de La Princesa, Madrid

28007

COMPLETED

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28031

COMPLETED

Hosp. Univ. Infanta Leonor, Madrid

28040

COMPLETED

Fundacion Jimenez Diaz, Madrid

29000

COMPLETED

Khmelnitskiy Regional Hospital, Hematology Department, Khmelnitskiy

30060

COMPLETED

Northwest Georgia Oncology Centers PC, Marietta

31008

COMPLETED

Clinica Universitaria de Navarra, Pamplona

31096

COMPLETED

Rambam Health Care Campus, Haifa

33604

RECRUITING

Hopital Haut Leveque Service Maladie Du Sang, Pessac

34365

COMPLETED

American Hospital, Istanbul

34390

COMPLETED

Istanbul University, Istanbul

35037

COMPLETED

OnkoNet Marburg GmbH, Marburg

35340

COMPLETED

Dokuz Eylul Universitesi Tip Fakultesi, Izmir

35592

RECRUITING

Justus-Liebig-Universitaet - Medizinische Klinik IV, Haematologie, Giessen

37007

RECRUITING

Hospital Clinico Universitario Salamanca, Salamanca

37044

RECRUITING

CHU de Tours, Tours

38039

COMPLETED

Erciyes University, Kayseri

38100

RECRUITING

Hillel Yaffe Medical Center - Oncology, Hadera

39104

COMPLETED

Gemeinschaftspraxis Dres. Uhle/Müller/Kröning/Jentsch-Ullrich - Germany, Magdeburg

40207

COMPLETED

Louisville Oncology Suburban - Norton Cancer Institute, Louisville

43210

RECRUITING

The Ohio State University- James Cancer Hospital, Columbus

45122

COMPLETED

Universitätsklinikum Essen; Klinik f. Hämatologie- Germany, Essen

46526

COMPLETED

Indiana University, Goshen

48109

COMPLETED

University of Michigan Comprehensive Cancer Center, Ann Arbor

48201

COMPLETED

Karmanos Cancer Institute - Wayne State University, Detroit

49016

COMPLETED

Battle Creek Health Systm, Battle Creek

49102

COMPLETED

Dnepropetrovsk City Clinical Hospital #4, Regional Hematology Center, Dnipro

52621

COMPLETED

Sheba Medical Center, Ramat Gan

53705

COMPLETED

University of Wisconsin Carbone Cancer Center - Wisconsin Institute for Medical Research, Madison

57105

RECRUITING

Avera Medical Group, Sioux Falls

60611

COMPLETED

Northwestern University Hospital, Chicago

61024

COMPLETED

SI Grigoriev Institute for Medical Radiology National Academy of Medical Science of Ukraine, Kharkiv

63110

COMPLETED

Washington University, St Louis

64239

RECRUITING

Tel Aviv Sourasky Medical Center, Tel Aviv

66205

COMPLETED

Kansas University Medical Center, Westwood

66424

COMPLETED

Universitätsklinikum des Saarlandes, Homburg/Saar

68000

COMPLETED

Oaxaca Site Management Organization S.C., Oaxaca City

68100

COMPLETED

Hôpital E. Muller, Mulhouse

69120

COMPLETED

Universitätsklinikum Heidelberg Med. Klinik IV, Heidelberg

69310

RECRUITING

CH LYON SUD - Hematology, Pierre-Bénite

75010

RECRUITING

HOPITAL SAINT LOUIS - Hematology / Oncology, Paris

75743

COMPLETED

Hopital Necker Enfants Malades, Paris

77030

COMPLETED

MD Anderson Cancer Center - University of Texas, Houston

79044

ACTIVE_NOT_RECRUITING

Institute of Blood Pathology and Transfusion Medicine of AMS of Ukraine, Lviv

89081

COMPLETED

Universitätsklinikum für Innere Med. III_Hämatologie, Onkologie...- Germany, Ulm

90095

COMPLETED

University of California Los Angeles, Los Angeles

91010

COMPLETED

City of Hope Cancer Center, Duarte

92093

COMPLETED

University of California San Diego Medical Center, La Jolla

92868

RECRUITING

St. Joseph Hospital Center for Cancer Prevention and Treatment, Orange

94010

RECRUITING

Hopital Henri Mondor, Créteil

94305

COMPLETED

Stanford University Medical Center, Stanford

COMPLETED

Stanford University, Stanford

97227

COMPLETED

Kaiser Permanente, Portland

97401

RECRUITING

Willamette Valley Cancer Center, Eugene

98109

COMPLETED

University of Washington, Seattle

100044

RECRUITING

Peking University People s Hospital, Beijing

100083

RECRUITING

Peking University Third Hospital, Beijing

115478

COMPLETED

Cancer Research Center, Moscow

125284

RECRUITING

S.P. Botkin Moscow City Clinical Hospital, Moscow

163045

COMPLETED

Arkhangelsk Regional Clinical Hospital, Arkhangelsk

167904

COMPLETED

Oncology Dispensary of Komi Republic, Syktyvkar

185019

RECRUITING

Republican Hospital named by V.A.Baranova, Petrozavodsk

193024

RECRUITING

Clinical Research Institute of Hematology and Transfusiology, Saint Petersburg

194291

COMPLETED

Leningrad region clinical hospital, Saint

197341

RECRUITING

Federal Center of Heart, Blood and Endocrinology, Saint Petersburg

198255

COMPLETED

City Clinical Oncology Dispensary, Saint Petersburg

200025

RECRUITING

Ruijin Hospital, Shanghai

249020

COMPLETED

Medical Scientific Radiology - Center, Obninsk

300070

COMPLETED

The Institute of Hematological disease, Tianjin

310003

RECRUITING

Zhejiang University First Hospital, Hangzhou

344037

COMPLETED

Rostov Research Institute of Oncology, Rostov-on-Don

350001

COMPLETED

Fujian Medical University, Fuzhou

354057

RECRUITING

Oncological dispensary #2, Sochi

390039

RECRUITING

Ryazan Regional Clinical Hospital, Ryazan

430023

COMPLETED

Wuhan Union Hospital, Wuhan

443095

COMPLETED

Samara Region Clinical Hospital, Samara

454087

COMPLETED

Chelyabinsk Regiona Onc. Center, Chelyabinsk

510060

RECRUITING

Sun Yat-sen University Cancer Hospital, Guangzhou

603126

RECRUITING

Regional Clinical Hospital n.a.Semashko, Nizhny Novgorod

606019

RECRUITING

Emergency Hospital of Dzerzhinsk, Dzerzhinsk

610041

RECRUITING

West China Hospital Sichuan University, Chengdu

614078

COMPLETED

Perm Medical Sanitary Unit#1, Perm

681002

COMPLETED

Fundacion Oftalmologica de Santander - FOSCAL, Floridablanca

710038

RECRUITING

Tangdu hospital the Fourth Military Medical, Shanxi

4200072

ACTIVE_NOT_RECRUITING

Instituto Portugues de Oncologia, Porto

4941492

COMPLETED

Rabin Medical Center Beilinson Campus, Petah Tikva

06850

COMPLETED

Norwalk Medical Group, Norwalk

02215

COMPLETED

Dana Farber Cancer Center, Boston

03756

COMPLETED

Dartmouth Hitchcock Medical Center, Lebanon

07601

COMPLETED

Hackensack University Medical Center, Hackensack

C1431

ACTIVE_NOT_RECRUITING

CEMIC Saavedra, Ciudad Autonoma Buenos Aires

C1114AAP

COMPLETED

Fundaleu, Ciudad de Buenos Aires

20231 050

COMPLETED

Ministerio da Saude Instituto Nacional do Cancer, Rio de Janeiro

40050 410

COMPLETED

Santa Casa da Misericórdia da Bahia - Hospital Santa Isabel, Salvador

01236-030

COMPLETED

Instituto de Ensino e Pesquisa São Lucas, São Paulo

H3T 1E2

COMPLETED

Jewish General Hospital, Montreal

Unknown

RECRUITING

Peking University First Hospital, Beijing

RECRUITING

The First Affliated Hospital of Soochow University, Suzhou

COMPLETED

Fundacion Santa Fe, Bogotá

COMPLETED

Haemek Medical Center, Afula

625 00

COMPLETED

Fakultni nemocnice Brno, Interni hematologicka a onkologicka klinika, Brno

100 34

COMPLETED

Fakultni nemocnice Kralovske Vinohrady - Interni hematologicka klinika, Prague

128 08

COMPLETED

Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie, Prague

01307

COMPLETED

Universitätsklinikum Carl Gustav Carus; Med. Klinik und Poliklinik I - Hämatologische Ambulanz, Haus, Dresden

115 27

COMPLETED

Laiko General Hospital - 1st department of Internal Medicine, Athens

570 10

COMPLETED

G Papanikolaou Hospital of Thessaloniki, Thessalonikis

00000

COMPLETED

St James's Hospital, Dublin

RECRUITING

Hospital Vall d'Hebron, Barcelona

COMPLETED

Christie Hospital, Manchester

00161

COMPLETED

DIPARTIMENTO DI BIOTECNOLOGIE CELLULARI ED EMATOLOGIA - UNIVERSITà ''LA SAPIENZA'', Roma

113 8677

ACTIVE_NOT_RECRUITING

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyō City

734 8551

RECRUITING

Hiroshima University Hospital, Hiroshima

060-8648

COMPLETED

Hokkaido University Hospital, Sapporo

1081 HV

COMPLETED

VU medisch centrum - Afd.Interne - INT, Amsterdam

36-200

COMPLETED

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza, Brzozów

41-500

RECRUITING

Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich, Chorzów

80 952

RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

30 510

RECRUITING

Pratia MCM Krakow, Krakow

45-061

RECRUITING

Oddzial Hematologii, Opole

76-200

RECRUITING

Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka, Słupsk

50 367

RECRUITING

Katedra I Klinika Hematologii Nowotworow Krwi I Transplantacji Szpiku, Wroclaw

1649-035

COMPLETED

Hospital De Santa Maria, Lisbon

00919

RECRUITING

Auxilio Mutuo Cancer Center, San Juan

06591

RECRUITING

The Catholic University of Korea Seoul St Mary s Hospital, Seoul

08907

COMPLETED

Inst. Cat. Doncologia-H Duran I Reynals, L'Hospitalet de Llobregat

SE-413 45

COMPLETED

Sahlgrenska University hospital, Hematology Dept, Gothenburg

171 76

COMPLETED

Karolinska Universitetssjukhuset Solna, Centrum för Hematologi, Stockholm, Stockholm

03115

COMPLETED

State Institution Scientific Center for Radiation Medicine Academy of Medical Sciences of Ukraine, Kiev

B15 2TH

RECRUITING

University Hospitals Birmingham NHS Trust,, Birmingham

BH7 7DW

COMPLETED

Royal Bournemouth Hospital, Bournemouth

CO4 5JL

RECRUITING

Colchester Hospital University NHS, Colchester

G12 0YN

COMPLETED

Beatson West Of Scotland Cancer Centre, Glasgow

LS9 7TF

COMPLETED

St James's Institute of Oncology, Leeds

LE1 5WW

COMPLETED

Leicester Royal Infirmary - Haematology, Leicester

EC1A 7BE

COMPLETED

St Bartholomew's Hospital - Dept of Haematology, London

NW1 2BU

COMPLETED

University College London Hospitals NHSFT, London

SE5 9RS

COMPLETED

Kings College Hospital, London

NG5 1PB

COMPLETED

Nottingham University Hospitals NHS Trust, Nottingham

PL6 8DH

COMPLETED

Derriford Hospital, Plymouth

S10 2JF

COMPLETED

Royal Hallamshire Hospital, Sheffield

SO16 6YD

COMPLETED

Southampton General Hospital, Southampton

SM2 5PT

RECRUITING

Royal Marsden Hospital (Sutton), Sutton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pharmacyclics LLC.

INDUSTRY

lead

Janssen Research & Development, LLC

INDUSTRY

NCT01804686 - A Long-term Extension Study of PCI-32765 (Ibrutinib) | Biotech Hunter | Biotech Hunter