Sipuleucel-T With Immediate vs. Delayed Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Blockade for Prostate Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

April 22, 2014

Primary Completion Date

February 27, 2020

Study Completion Date

August 31, 2020

Conditions
Prostate Cancer
Interventions
DRUG

SipT Treatment

"All patients will receive standard of care SipT treatment every two weeks for a total of 3 treatments. The three treatments usually take about 30 days to complete.~SipT treatment is given in three 1 hour infusions. Each SipT treatment is generated from a standard blood cell-collection procedure (called leukapheresis) performed 2-3 days prior to the infusion."

DRUG

Ipilimumab

Ipilimumab will be given by IV over 90 minutes every 3 weeks. Patients will be monitored during the infusion and up to 1 hour post-infusion.

Trial Locations (2)

77030

The University of Texas MD Anderson Cancer Center, Houston

94115

University of California San Francisco, San Francisco

Sponsors
All Listed Sponsors
collaborator

M.D. Anderson Cancer Center

OTHER

collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Dendreon

INDUSTRY

lead

University of California, San Francisco

OTHER