29
Participants
Start Date
April 24, 2013
Primary Completion Date
January 31, 2019
Study Completion Date
January 31, 2019
Hydroxyurea
Hydroxyurea will be prescribed as an investigational therapy by the treating physician. Recommended guidelines for titration of hydroxyurea to maximal tolerated dose are below. The study intervention will include hydroxyurea to begin at \~20 mg/kg/day (range 17.5 - 26 mg/kg/day). No dose escalation will occur as this dose was shown to have some efficacy in infants with SCA and was associated with rare myelosuppression.(1)
Aminu Kano Teaching Hospital, Kano
National Institutes of Health (NIH)
NIH
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Aminu Kano Teaching Hospital
OTHER
Vanderbilt University Medical Center
OTHER