A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes

PHASE3CompletedINTERVENTIONAL
Enrollment

5,047

Participants

Timeline

Start Date

May 31, 2013

Primary Completion Date

April 30, 2021

Conditions
Type 2 DiabetesComparative Effectiveness of Glycemia-lowering Medications
Interventions
DRUG

Sulfonylurea (glimepiride)

Used in accordance with labeling and/or usual practice.

DRUG

DPP-4 inhibitor (sitagliptin)

Used in accordance with labeling and/or usual practice

DRUG

GLP-1 receptor agonist (liraglutide)

Used in accordance with labeling and/or usual practice.

DRUG

Insulin (glargine)

Used in accordance with labeling and/or usual practice.

Trial Locations (36)

Unknown

University of Alabama-Birmingham, Birmingham

Southwestern American Indian Center, Phoenix

Veterans Medical Research Foundation, San Diego (San Diego VA), San Diego

University of Colorado, Denver

Yale University School of Medicine, New Haven

South Florida VA Foundation (Miami VA), Miami

Atlanta VA Medical Center, Decatur

Kaiser Permanente of Georgia, Duluth

Pacific Health Research and Education Institute (VA Pacific Islands), Honolulu

Indiana University School of Medicine, Indianapolis

University of Iowa, Iowa City

Pennington Biomedical Research Center, Baton Rouge

MedStar Health Research Institute, Hyattsville

Massachusetts General Hospital, Boston

University of Michigan, Ann Arbor

International Diabetes Center, Minneapolis

University of Minnesota, Minneapolis

Washington University School of Medicine, St Louis

University of Nebraska, Omaha

University of New Mexico School of Medicine, Albuquerque

State University of New York (SUNY)-Downstate Medical Center, Brooklyn

Columbia University Naomi Berrie Diabetes Center, New York

Mount Sinai St. Luke's Hospital, New York

Albert Einstein College of Medicine, The Bronx

Duke University Medical Center, Durham

University of North Carolina Diabetes Care Center, Durham

University of Cincinnati, Cincinnati

Case Western Reserve University School of Medicine, Cleveland

Kaiser Permanente Northwest, Portland

Oregon Health and Science University, Portland

Vanderbilt University Medical Center, Nashville

Baylor Endocrine Center, Dallas

University of Texas-Southwestern Medical Center, Dallas

Baylor College of Medicine, Houston

University of Texas Health Science Center, San Antonio

Seattle Institute for Biomedical and Clinical Research, Seattle

All Listed Sponsors
collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Becton, Dickinson and Company

INDUSTRY

collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Novo Nordisk A/S

INDUSTRY

collaborator

Roche Diagnostics GmbH

INDUSTRY

collaborator

Sanofi

INDUSTRY

collaborator

Centers for Disease Control and Prevention

FED

lead

GRADE Study Group

OTHER