Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD

PHASE2CompletedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

May 13, 2013

Primary Completion Date

December 3, 2015

Study Completion Date

February 1, 2017

Conditions
Posttraumatic Stress Disorder
Interventions
DRUG

Comparator Dose (40mg) MDMA HCl

An initial comparator-dose of 40 mg midomafetamine HCl orally given at the start of two separate psychotherapy sessions scheduled 3 to 5 weeks apart, with the initial dose possibly followed 1.5 to 2.5 hours later by a supplemental dose half the size of the initial dose (20 mg).

DRUG

Active Dose 2 (100 mg) MDMA HCl

An initial dose of full-dose 100 mg midomafetamine HCl orally given at the start of two separate psychotherapy sessions scheduled 3 to 5 weeks apart, with the initial dose possibly followed 1.5 to 2.5 hours later by a supplemental dose half the size of the initial dose (50 mg).

DRUG

Active Dose 1 (125 mg) MDMA HCl

An initial dose of full-dose 125 mg midomafetamine HCl orally given at the start of two separate psychotherapy sessions scheduled 3 to 5 weeks apart, with the initial dose possibly followed 1.5 to 2.5 hours later by a supplemental dose half the size of the initial dose (62.5 mg).

BEHAVIORAL

Psychotherapy

Non-directive manualized therapy

Trial Locations (1)

80304

Offices of Marcela d'Otalora, Boulder

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Lykos Therapeutics

INDUSTRY