Chemotherapy and Maximal Tumor Debulking of Multi-organ Colorectal Cancer Metastases

NAActive, not recruitingINTERVENTIONAL
Enrollment

478

Participants

Timeline

Start Date

May 31, 2013

Primary Completion Date

January 31, 2025

Study Completion Date

July 31, 2027

Conditions
Multi-organ Metastatic Colorectal Cancer
Interventions
DRUG

XELOX regimen according to standard procedures

DRUG

FOLFOX regimen according to standard procedures

PROCEDURE

Surgery

OTHER

radiofrequency ablation (RFA)

OTHER

transarterial chemo-embolization using irinotecan drug-eluted beads ((DEBIRI-)TACE)

RADIATION

stereotactic body radiation therapy (SBRT)

DRUG

Bevacizumab

may be added to both regimens according to standard procedures

PROCEDURE

tumor biopsy

at baseline (diagnostic or study) biopsy and after 3 or 4 cycles an optional tumor biopsy

Trial Locations (29)

Unknown

Jeroen Bosch Ziekenhuis, 's-Hertogenbosch

Noordwest Ziekenhuis Groep, Alkmaar

Ziekenhuisgroep Twente, Almelo

Meander Medisch Centrum, Amersfoort

Amstelveen Ziekenhuis, Amstelveen

Antoni van Leeuwenhoek, Amsterdam

Gelre, Apeldoorn

Amphia Ziekenhuis, Breda

Deventer Ziekenhuis, Deventer

Albert Schweizer ziekenhuis, Dordrecht

Maxima Medisch Centrum, Eindhoven

Medisch Spectrum Twente, Enschede

Admiraal de Ruyter Hospital, Flushing

Dijklander, Hoorn

Medisch Centrum Leeuwarden, Leeuwarden

Sint Antonius Ziekenhuis, Nieuwegein

Radboud University Medical Center, Nijmegen

Bravis ziekenhuis, Roosendaal

Franciscus Gasthuis, Rotterdam

IJsselland ziekenhuis, Rotterdam

Maasstadziekenhuis, Rotterdam

Medisch Centrum Haaglanden, The Hague

Elisabeth Tweesteden Ziekenhuis, Tilburg

Zaans Medisch Centrum, Zaandam

Isala Klinieken, Zwolle

University College London Hospital, London

University Hospital Southampton, Southampton

NL-1081 HV

VU Medical Center, Amsterdam

NL-3075 EA

Erasmus University Medical Center, Rotterdam

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Erasmus Medical Center

OTHER

lead

Radboud University Medical Center

OTHER