ECHELON-2: A Comparison of Brentuximab Vedotin and CHP With Standard-of-care CHOP in the Treatment of Patients With CD30-positive Mature T-cell Lymphomas

PHASE3CompletedINTERVENTIONAL
Enrollment

452

Participants

Timeline

Start Date

January 31, 2013

Primary Completion Date

August 15, 2018

Study Completion Date

October 2, 2020

Conditions
Anaplastic Large-Cell LymphomaNon-Hodgkin LymphomaT-Cell Lymphoma
Interventions
DRUG

brentuximab vedotin

1.8 mg/kg every 3 weeks by IV infusion for 6-8 cycles

DRUG

doxorubicin

50 mg/m2 every 3 weeks by IV infusion for 6-8 cycles

DRUG

prednisone

100 mg on Days 1 to 5 of each 3-week cycle, orally for 6-8 cycles

DRUG

vincristine

1.4 mg/m2 (maximum 2 mg) every 3 weeks by IV infusion for 6-8 cycles

DRUG

cyclophosphamide

750 mg/m2 every 3 weeks by IV infusion for 6-8 cycles

Trial Locations (144)

404

China Medical University Hospital, Taichung

1083

Semmelweis Egyetem, Budapest

2010

St. Vincent's Hospital Sydney, Darlinghurst

2139

Concord Repatriation General Hospital, Concord

2298

Calvary Mater Newcastle, Waratah

3011

Western Hospital, Footscray

3065

St Vincent's Public Hospital Sydney - Fitzroy, Fitzroy

3084

Austin Health, Heidelberg

3165

Moorabbin Hospital, Bentleigh East

3168

Monash Medical Centre, Clayton

4032

Icon Cancer Care Chermside, Chermside

Icon Cancer Care South Brisbane, Chermside

Icon Cancer Care Southport, Chermside

Icon Cancer Care Wesley, Chermside

Debreceni Egyetem, Debrecen

5000

Royal Adelaide Hospital, Adelaide

Odense University Hospital, Odense C

7400

Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár

8000

Aarhus University Hospital, Aarhus C

9700

Markusovszky Egyetemi Oktatokorhaz, Szombathely

10021

Memorial Sloan Kettering Cancer Center, New York

10022

Columbia University Medical Center, New York

10065

Weill Cornell Medical College, New York

10117

Charite Universitatsmedizin Berlin, Berlin

10126

Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino

10461

Albert Einstein Cancer Center, The Bronx

10467

Montefiore Medical Center, The Bronx

11725

Memorial Sloan Kettering Cancer Center - Commack, Commack

12203

Charite Campus Benjamin Franklin, Berlin

14642

James P. Wilmot Cancer Center / University of Rochester Medical Center, Rochester

15121

Azienda Ospedaliera SS. Antonio E. Biagio E. Cesare Arrigo di Alessandria, Alessandria

16132

Azienda Ospedaliera Universitaria San Martino, Genova

20089

Istituto Clinico Humanitas-Humanitas Cancer Center, Rozzano

20122

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan

20162

Ospedale Niguarda Ca' Granda, Milan

22908

University of Virginia, Charlottesville

23298

Virginia Commonwealth University Medical Center, Richmond

24071

Hospital de León, León

24127

Azienda Ospedaliera Papa Giovanni XXIII, Bergamo

25123

Azienda Ospedaliera Spedali Civili di Brescia, Brescia

27100

IRCSS Policlinico San Matteo, Pavia

28007

Hospital General Universitario Gregorio Marañon, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Hospital Universitario La Paz, Madrid

28222

Hospital Puerta de Hierro Majadahonda, Majadahonda

30384

Sarah Cannon Research Institute, Nashville

31096

Rambam Health Corp., Haifa

32610

Shands Cancer Center / University of Florida, Gainesville

32806

Orlando Health, Inc., Orlando

33305

Chang Gung Memorial Hospital - Taoyuan, Taoyuan District

33604

Groupe Hospitalier du Haut Leveque, Pessac

35033

Centre Hospitalier Universitaire de Rennes, Hopital Pontchaillou, Rennes

37007

Hospital Universitaro de Salamanca, Salamanca

37075

Georg-August-Universität Göttingen, Göttingen

37134

Azienda Ospedaliera Universitaria Integrata di Verona, Verona

38700

Centre Hospitalier Universitaire de Grenoble, La Tronche

40138

Instituto di Ematologia ed Oncologia Medica, Bologna

41013

Hospital Universitario Virgen del Rocio, Seville

44093

Centre Hospitalier Universitaire Nantes-Hotel Dieu, Nantes

44195

Cleveland Clinic, The, Cleveland

45122

Universitatsklinikum Essen, Essen

45236

Jewish Hospital, The, Cincinnati

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

49414

Rabin Medical Center, Petah Tikva

50937

Universitatsklinikum Koln, Cologne

52242

Holden Comprehensive Cancer Center / University of Iowa, Iowa City

59037

CHRU de Lille, Lille

60153

Cardinal Bernardin Cancer Center / Loyola University Medical Center, Maywood

60488

Krankenhaus Nordwest GmbH, Frankfurt am Main

60612

University of Illinois at Chicago, Chicago

61100

Azienda Ospedaliera Ospedali Riuniti Marche Nord, Pesaro

63110

Washington University School of Medicine, St Louis

64239

Tel Aviv Sourasky Medical Center, Tel Aviv

66421

Universitätsklinikum des Saarlandes, Homburg/Saar

69120

Universitätsklinikum Heidelberg, Heidelberg

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

70403

National Cheng-Kung University Hospital, Tainan City

72000

Clinique Victor Hugo, Le Mans

73120

Mercy Clinic Oncology, Oklahoma City

75013

Groupe Hospitalier Pitié-Salpétrière, Paris

75246

Charles A. Sammons Cancer Center / Baylor University Medical Center, Dallas

75475

Hopital Saint-Louis / Service d'Hematologie, Paris

76038

Centre Henri Becquerel / Centre Regional de Lutte Contre le Cancer, Rouen

81377

Klinikum der Ludwig-Maximilians-Universität München, München

83301

Chang Gung Memorial Hospital - Kaohsiung, Kaohsiung City

84101

Soroka Medical Center, Dept. of Oncology, Beersheba

85234

Banner MD Anderson Cancer Center, Gilbert

85925

CHD Vendée, Site de La Roche-sur-Yon, Les Oudairies, La Roche-sur-Yon

86021

Centre Hospitalier Universitaire de Poitiers, Poitiers

87042

Centre Hospitalier Universitaire (CHU) De Limoges - Hopital Dupuytren, Limoges

89081

Universitätsklinikum Ulm, Ulm

90419

Klinikum Nürnberg, Nuremberg

91120

Hadassah Medical Center, Jerusalem

94010

Hôpital Henri Mondor, Créteil

94305

Stanford Cancer Center, Stanford

95124

Azienda Ospedaliera-Universitaria Vittorio Emanuele-Ferrarotto-Santo Bambino, Catania

98101

Benaroya Research Institute/Virginia Mason Medical Center, Seattle

400015

"Institutul Oncologic Prof. Dr. I. Chiricuta Cluj-Napoca", Cluj-Napoca

540136

Spitalul Clinic Judetean de Urgenta Targu Mures, Sectia Clinica Hematologie si Transplant Medular, Târgu Mureş

91010-3000

City of Hope National Medical Center, Duarte

United States

University of Kansas Cancer Center, Westwood

Thomas Jefferson University, Philadelphia

02215

Beth Israel Deaconess Medical Center, Boston

Dana Farber Cancer Institute, Boston

07920

Memorial Sloan Kettering Cancer Center - Basking Ridge, Basking Ridge

07601

Hackensack University Medical Center, Hackensack

77030-4095

MD Anderson Cancer Center / University of Texas, Houston

98109-1023

Seattle Cancer Care Alliance / University of Washington, Seattle

H3H 2R9

McGill University Department of Oncology / McGill University Health Centre, Montreal

H3T 1E2

Jewish General Hospital, Montreal

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

V5Z 4E6

British Columbia Cancer Agency - Vancouver Centre, Vancouver

625 00

Fakultni nemocnice Brno, Brno

500 05

Fakultni nemocnice Hradec Kralove-oddeleni klinicke hematologie, Hradec Králové

708 52

Fakultni Nemocnice Ostrava, Ostrava - Poruba

100 34

Fakultni Nemocnice Kralovske Vinohrady, Prague

128 08

Vseobecna fakultni nemocnice v Praze, Prague

DK 2100

Rigs Hospiltalet, Copenhagen

09113

Klinikum Chemnitz gGmbH, Chemnitz

07747

Klinik für Innere Medizin II, Friedrich-Schiller-Universität, Jena

00161

"Università degli Studi di Roma La Sapienza, Policlinico Umberto I", Roma

36-200

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza, Brzozów

41-500

Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespól Szpitali Miejskich, Chorzów

30-510

Malopolskie Centrum Medyczne S.C., Krakow

02-781

Centrum Onkologii Institut im. Marii Sklodowskiej-Curie, Warsaw

022328

Institutul Clinic Fundeni, Centrul de Hematologie si Transplant Medular Stefan Berceanu, Bucharest

030171

Spitalul Clinic Coltea, Bucharest

700-712

Keimyung University Dongsan Medical Center, Daegu

519-763

Chonnam National University Hwasun Hospital, Hwasun

463-707

Seoul National University Bundang Hospital, Seongnam-si

110-744

Seoul National University Hospital, Seoul

120-752

Severance Hospital, Yonsei University Health System, Seoul

135-710

Samsung Medical Center, Seoul

137-701

Seoul Saint Mary's Hospital, Seoul

138-876

Asan Medical Center, Seoul

08025

Hospital de la Santa Creu i Sant Paul, Barcelona

08028

Institut Universitari Dexeus, Barcelona

08907

Institut Català D'oncologia, L'Hospitalet de Llobregat

CB2 0QQ

Addenbrooke's Hospital, Cambridge

LE1 5WW

University Hospitals of Leicester NHS Trust, Leicester

SW17 0RE

Saint George's Hospital NHS Trust, London

M20 4BX

Christie Hospital NHS Foundation Trust, Manchester

NE7 7DN

Freeman Hospital, Newcastle upon Tyne

NG5 1PD

Nottingham University Hospitals NHS Trust, Nottingham

Sponsors
All Listed Sponsors
collaborator

Millennium Pharmaceuticals, Inc.

INDUSTRY

lead

Seagen Inc.

INDUSTRY