40
Participants
Start Date
January 31, 2013
Primary Completion Date
July 31, 2018
Study Completion Date
December 31, 2019
Leucovorin
200mg/m2 administered IV on Days 1 and 15 of a 28 day cycle. Number of Cycles: until progression or unacceptable toxicity develops.
Fluorouracil
5-FU continuous infusion: 2400mg/m2 total (1200mg/m2/d on day 1 and 2) to start on Day 1 and Day 15 of each 28 day cycle. Number of Cycles: until progression or unacceptable toxicity develops.
Oxaliplatin
85 mg/m2 IV on Days 1 and 15 of each 28 day cycle. Number of Cycles: until progression or unacceptable toxicity develops.
Sorafenib
400mg po BID continuously for a 2 week lead-in phase and then Days 1-28 of each 28 day cycle. Number of Cycles: until progression or unacceptable toxicity develops.
Massachusetts General Hospital, Boston
Dana-Farber Cancer Institute, Boston
Brigham and Women's Hospital, Boston
Massachusetts General Hospital
OTHER