73
Participants
Start Date
February 12, 2013
Primary Completion Date
June 30, 2018
Study Completion Date
September 30, 2022
Dinutuximab
Given IV
Irinotecan Hydrochloride
Given IV
Laboratory Biomarker Analysis
Optional correlative studies
Sargramostim
Given SC or IV
Temozolomide
Given PO
Temsirolimus
Given IV
Starship Children's Hospital, Grafton
Sydney Children's Hospital, Randwick
The Children's Hospital at Westmead, Westmead
Royal Children's Hospital-Brisbane, Herston
Queensland Children's Hospital, South Brisbane
Princess Margaret Hospital for Children, Perth
Christchurch Hospital, Christchurch
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
Montefiore Medical Center - Moses Campus, The Bronx
New York Medical College, Valhalla
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
NYU Winthrop Hospital, Mineola
Albany Medical Center, Albany
State University of New York Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Rochester, Rochester
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
Penn State Children's Hospital, Hershey
Children's Hospital of Philadelphia, Philadelphia
Saint Christopher's Hospital for Children, Philadelphia
Alfred I duPont Hospital for Children, Wilmington
MedStar Georgetown University Hospital, Washington D.C.
Children's National Medical Center, Washington D.C.
Sinai Hospital of Baltimore, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
University of Virginia Cancer Center, Charlottesville
Virginia Commonwealth University/Massey Cancer Center, Richmond
Children's Hospital of The King's Daughters, Norfolk
West Virginia University Healthcare, Morgantown
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
Duke University Medical Center, Durham
Carolinas Medical Center/Levine Cancer Institute, Charlotte
Mission Hospital, Asheville
Prisma Health Richland Hospital, Columbia
BI-LO Charities Children's Cancer Center, Greenville
Children's Healthcare of Atlanta - Egleston, Atlanta
Memorial Health University Medical Center, Savannah
Nemours Children's Clinic-Jacksonville, Jacksonville
Nemours Children's Clinic - Pensacola, Pensacola
University of Florida Health Science Center - Gainesville, Gainesville
AdventHealth Orlando, Orlando
Nemours Children's Clinic - Orlando, Orlando
Nemours Children's Hospital, Orlando
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Nicklaus Children's Hospital, Miami
Saint Mary's Hospital, West Palm Beach
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
Johns Hopkins All Children's Hospital, St. Petersburg
Lee Memorial Health System, Fort Myers
Golisano Children's Hospital of Southwest Florida, Fort Myers
The Children's Hospital at TriStar Centennial, Nashville
Vanderbilt University/Ingram Cancer Center, Nashville
East Tennessee Childrens Hospital, Knoxville
University of Mississippi Medical Center, Jackson
Norton Children's Hospital, Louisville
University of Kentucky/Markey Cancer Center, Lexington
Nationwide Children's Hospital, Columbus
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Rainbow Babies and Childrens Hospital, Cleveland
Children's Hospital Medical Center of Akron, Akron
Cincinnati Children's Hospital Medical Center, Cincinnati
Dayton Children's Hospital, Dayton
Riley Hospital for Children, Indianapolis
Ascension Saint Vincent Indianapolis Hospital, Indianapolis
C S Mott Children's Hospital, Ann Arbor
Wayne State University/Karmanos Cancer Institute, Detroit
Ascension Saint John Hospital, Detroit
Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids
Blank Children's Hospital, Des Moines
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Children's Hospital of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center, Madison
Marshfield Medical Center-Marshfield, Marshfield
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
University of Minnesota/Masonic Cancer Center, Minneapolis
Mayo Clinic in Rochester, Rochester
Sanford Broadway Medical Center, Fargo
Loyola University Medical Center, Maywood
Advocate Children's Hospital-Oak Lawn, Oak Lawn
Lurie Children's Hospital-Chicago, Chicago
University of Illinois, Chicago
University of Chicago Comprehensive Cancer Center, Chicago
Saint Jude Midwest Affiliate, Peoria
Southern Illinois University School of Medicine, Springfield
Washington University School of Medicine, St Louis
Mercy Hospital Saint Louis, St Louis
Children's Mercy Hospitals and Clinics, Kansas City
Children's Hospital and Medical Center of Omaha, Omaha
University of Nebraska Medical Center, Omaha
Children's Hospital New Orleans, New Orleans
Ochsner Medical Center Jefferson, New Orleans
University of Arkansas for Medical Sciences, Little Rock
University of Oklahoma Health Sciences Center, Oklahoma City
Medical City Dallas Hospital, Dallas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
Cook Children's Medical Center, Fort Worth
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
Children's Hospital of San Antonio, San Antonio
Methodist Children's Hospital of South Texas, San Antonio
Dell Children's Medical Center of Central Texas, Austin
Covenant Children's Hospital, Lubbock
Children's Hospital Colorado, Aurora
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver
Saint Luke's Cancer Institute - Boise, Boise
Primary Children's Hospital, Salt Lake City
Phoenix Childrens Hospital, Phoenix
University of New Mexico Cancer Center, Albuquerque
University Medical Center of Southern Nevada, Las Vegas
Sunrise Hospital and Medical Center, Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas
Summerlin Hospital Medical Center, Las Vegas
Nevada Cancer Research Foundation NCORP, Las Vegas
Children's Hospital Los Angeles, Los Angeles
Kaiser Permanente Downey Medical Center, Downey
Rady Children's Hospital - San Diego, San Diego
Loma Linda University Medical Center, Loma Linda
Children's Hospital of Orange County, Orange
Valley Children's Hospital, Madera
UCSF Medical Center-Parnassus, San Francisco
UCSF Medical Center-Mission Bay, San Francisco
Lucile Packard Children's Hospital Stanford University, Palo Alto
Kaiser Permanente-Oakland, Oakland
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
University of Hawaii Cancer Center, Honolulu
Kapiolani Medical Center for Women and Children, Honolulu
Legacy Emanuel Children's Hospital, Portland
Oregon Health and Science University, Portland
Seattle Children's Hospital, Seattle
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
Arkansas Children's Hospital, Little Rock
Connecticut Children's Medical Center, Hartford
Yale University, New Haven
Eastern Maine Medical Center, Bangor
Dana-Farber Cancer Institute, Boston
Michigan State University Clinical Center, East Lansing
Dartmouth Hitchcock Medical Center, Lebanon
Hackensack University Medical Center, Hackensack
Morristown Medical Center, Morristown
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick
Sanford USD Medical Center - Sioux Falls, Sioux Falls
University of Vermont and State Agricultural College, Burlington
Alberta Children's Hospital, Calgary
University of Alberta Hospital, Edmonton
British Columbia Children's Hospital, Vancouver
CancerCare Manitoba, Winnipeg
Janeway Child Health Centre, St. John's
IWK Health Centre, Halifax
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton
Children's Hospital, London
Children's Hospital of Eastern Ontario, Ottawa
Hospital for Sick Children, Toronto
The Montreal Children's Hospital of the MUHC, Montreal
Centre Hospitalier Universitaire Sainte-Justine, Montreal
Centre Hospitalier Universitaire de Quebec, Québec
San Jorge Children's Hospital, San Juan
Collaborators (1)
United Therapeutics
INDUSTRY
National Cancer Institute (NCI)
NIH