776
Participants
Start Date
April 30, 2013
Primary Completion Date
January 31, 2015
Study Completion Date
January 31, 2015
Sarilumab
Pharmaceutical form: Solution for injection in pre-filled syringe; Route of administration: Subcutaneous
Etanercept
Pharmaceutical form: Solution for injection in pre-filled syringe; Route of administration: Subcutaneous
Methotrexate
Dispensed according to local practice.
Placebo (for sarilumab)
Placebo (for etanercept)
Adalimumab
Pharmaceutical form: Solution for injection in pre-filled syringe; Route of administration: Subcutaneous
Investigational Site Number 170016, Bogotá
Investigational Site Number 604010, Lima
Investigational Site Number 158006, Taipei
Investigational Site Number 158010, Changhua
Investigational Site Number 158004, Chiayi City
Investigational Site Number 158012, Kaohsiung City
Investigational Site Number 158011, Kaohsiung City
Investigational Site Number 348001, Budapest
Investigational Site Number 554007, Auckland
Investigational Site Number 554011, Nelson
Investigational Site Number 036020, Camperdown
Investigational Site Number 348021, Esztergom
Investigational Site Number 036004, Heidelberg West
Investigational Site Number 484029, Deleg. Benito Juárez
Investigational Site Number 554005, Hamilton
Investigational Site Number 032005, San Miguel de Tucumán
Investigational Site Number 348010, Debrecen
Investigational Site Number 036007, Woodville
Investigational Site Number 348008, Gyula
Investigational Site Number 036014, Victoria Park
Investigational Site Number 484052, Mexico City
Investigational Site Number 710011, Cape Town
Investigational Site Number 710007, Cape Town
Investigational Site Number 710010, Stellenbsoch
Investigational Site Number 554010, Dunedin
Investigational Site Number 348013, Gy?r
Investigational Site Number 840056, New York
Investigational Site Number 764002, Bangkok
Investigational Site Number 764010, Bangkok
Investigational Site Number 458014, George Town
Investigational Site Number 203032, Prague
Investigational Site Number 300010, Athens
Investigational Site Number 276007, Berlin
Investigational Site Number 276057, Berlin
Investigational Site Number 203001, Prague
Investigational Site Number 724043, Córdoba
Investigational Site Number 203031, Prague
Investigational Site Number 203033, Prague
Investigational Site Number 276053, Ludwigsfelde
Investigational Site Number 724009, A Coruña
Investigational Site Number 840117, Pittsburgh
Investigational Site Number 458013, Kota Bharu
Investigational Site Number 724012, Santiago de Compostela
Investigational Site Number 380004, Genova
Investigational Site Number 380005, Genova
Investigational Site Number 840203, Washington D.C.
Investigational Site Number 484010, Mexicali
Investigational Site Number 484026, Mexicali
Investigational Site Number 840073, Cumberland
Investigational Site Number 840202, Hagerstown
Investigational Site Number 484051, Tijuana
Investigational Site Number 276013, Hamburg
Investigational Site Number 840124, Clarksburg
Investigational Site Number 724042, Madrid
Investigational Site Number 724041, Madrid
Investigational Site Number 246003, Pori
Investigational Site Number 724040, Madrid
Investigational Site Number 724001, Málaga
Investigational Site Number 840016, North Charleston
Investigational Site Number 458001, Ipoh
Investigational Site Number 250008, Toulouse
Investigational Site Number 484023, Chihuahua City
Investigational Site Number 376001, Haifa
Investigational Site Number 376010, Haifa
Investigational Site Number 840128, Ormond Beach
Investigational Site Number 840207, Tampa
Investigational Site Number 840210, Clearwater
Investigational Site Number 840060, Sarasota
Investigational Site Number 250002, Montpellier
Investigational Site Number 376031, Haifa
Investigational Site Number 840063, Palm Harbor
Investigational Site Number 840004, Birmingham
Investigational Site Number 380042, Valeggio sul Mincio
Investigational Site Number 840025, Jackson
Investigational Site Number 840037, Tupelo
Investigational Site Number 840200, Jackson
Investigational Site Number 764011, Khon Kaen
Investigational Site Number 804030, Lutsk
Investigational Site Number 484013, Guadalajara
Investigational Site Number 484018, Guadalajara
Investigational Site Number 276001, Herne
Investigational Site Number 840213, Indianapolis
Investigational Site Number 840150, Lansing
Investigational Site Number 804003, Dnipropetrovsk
Investigational Site Number 840204, Battle Creek
Investigational Site Number 380002, Florence
Investigational Site Number 376030, Ramat Gan
Investigational Site Number 376034, Tel Litwinsky
Investigational Site Number 300014, N. Efkarpia
Investigational Site Number 804010, Kharkiv
Investigational Site Number 804001, Kharkiv
Investigational Site Number 376011, Tel Aviv
Investigational Site Number 804032, Odesa
Investigational Site Number 804022, Odesa
Investigational Site Number 804012, Odesa
Investigational Site Number 380041, L’Aquila
Investigational Site Number 458012, Batu Caves
Investigational Site Number 840112, Lincoln
Investigational Site Number 804028, Zaporizhzhya
Investigational Site Number 458011, Seremban
Investigational Site Number 840109, Lake Charles
Investigational Site Number 300002, Heraklion
Investigational Site Number 250005, Paris
Investigational Site Number 840074, Mesquite
Investigational Site Number 250004, Paris
Investigational Site Number 458010, Malacca
Investigational Site Number 203006, Zlín
Investigational Site Number 804029, Ivano-Frankivsk
Investigational Site Number 484025, San Luis
Investigational Site Number 376032, Ashkelon
Investigational Site Number 804005, Lviv
Investigational Site Number 804033, Lviv
Investigational Site Number 804020, Lviv
Investigational Site Number 250003, Amiens
Investigational Site Number 840201, Denver
Investigational Site Number 804002, Donetsk
Investigational Site Number 840018, Idaho Falls
Investigational Site Number 250001, La Roche-sur-Yon
Investigational Site Number 246030, Oulu
Investigational Site Number 276051, Erlangen
Investigational Site Number 376035, Jerusalem
Investigational Site Number 840212, Glendale
Investigational Site Number 840211, Thousand Oaks
Investigational Site Number 840049, Upland
Investigational Site Number 840205, Victorville
Investigational Site Number 458002, Kuching
Investigational Site Number 804021, Simferopol
Investigational Site Number 484004, Mérida
Investigational Site Number 840061, Tacoma
Investigational Site Number 643052, Moscow
Investigational Site Number 643021, Moscow
Investigational Site Number 643031, Moscow
Investigational Site Number 643030, Moscow
Investigational Site Number 642022, Târgovişte
Investigational Site Number 643057, Yaroslavl
Investigational Site Number 643008, Saint Petersburg
Investigational Site Number 643059, Smolensk
Investigational Site Number 642012, Bucharest
Investigational Site Number 643011, Saratov
Investigational Site Number 643010, Samara
Investigational Site Number 643013, Ufa
Investigational Site Number 643022, Novosibirsk
Investigational Site Number 643006, Kemerovo
Investigational Site Number 643056, Krasnoyarsk
Investigational Site Number 642013, Iași
Investigational Site Number 642014, Iași
Investigational Site Number 642005, Galati
Investigational Site Number 152005, Osorno
Investigational Site Number 152018, Santiago
Investigational Site Number 840209, Danbury
Investigational Site Number 032052, Buenos Aires
Investigational Site Number 032050, Buenos Aires
Investigational Site Number 032053, La Plata
Investigational Site Number 032051, San Miguel de Tucumán
Investigational Site Number 076016, Curitiba
Investigational Site Number 152001, Santiago
Investigational Site Number 152002, Santiago
Investigational Site Number 152011, Santiago
Investigational Site Number 152015, Temuco
Investigational Site Number 170001, Bogotá
Investigational Site Number 170007, Bucaramanga
Investigational Site Number 170009, Bucaramanga
Investigational Site Number 170041, Medellín
Investigational Site Number 203030, Prague
Investigational Site Number 218003, Cuenca
Investigational Site Number 246032, Tampere
Investigational Site Number 250007, Bobigny
Investigational Site Number 250006, Strasbourg
Investigational Site Number 276058, Cologne
Investigational Site Number 276050, Rostock
Investigational Site Number 300012, Pátrai
Investigational Site Number 484027, Ciudad Obregón
Investigational Site Number 616015, Elblag
Investigational Site Number 616061, Krakow
Investigational Site Number 642041, Bacau
Investigational Site Number 642004, Bucharest
Investigational Site Number 642023, Bucharest
Investigational Site Number 642042, Bucharest
Investigational Site Number 643058, Saint Peterburg
Investigational Site Number 643050, Voronezh
Investigational Site Number 643051, Yaroslavl
Investigational Site Number 764003, Bangkok Noi
Investigational Site Number 804024, Donetsk
Investigational Site Number 804011, Kyiv
Investigational Site Number 804031, Zhytomyr
Investigational Site Number 826023, Barnsley
Investigational Site Number 826026, Durham
Investigational Site Number 826027, Durham
Investigational Site Number 032013, Rosario
Investigational Site Number 032009, Zárate
Investigational Site Number 076001, Curitiba
Investigational Site Number 076006, Goiânia
Investigational Site Number 076010, Juiz de Fora
Investigational Site Number 076005, Rio de Janeiro
Investigational Site Number 076013, Vitória
Investigational Site Number 170040, Bogotá
Investigational Site Number 203004, Ostrava
Investigational Site Number 203002, Uherské Hradiště
Investigational Site Number 218001, Guayaquil
Investigational Site Number 218002, Quito
Investigational Site Number 246001, Helsinki
Investigational Site Number 246002, Hyvinkää
Investigational Site Number 276056, Dresden
Investigational Site Number 276055, Dresden
Investigational Site Number 428002, Liepāja
Investigational Site Number 428001, Riga
Investigational Site Number 428003, Ventspils
Investigational Site Number 440005, Kaunas
Investigational Site Number 440006, Klaipėda
Investigational Site Number 440010, Panevezys
Investigational Site Number 440011, Vilnius
Investigational Site Number 484017, México
Investigational Site Number 604001, Lima
Investigational Site Number 604009, Lima
Investigational Site Number 604012, Lima
Investigational Site Number 604007, Lima
Investigational Site Number 604005, Lima
Investigational Site Number 604020, Lima
Investigational Site Number 616019, Bydgoszcz
Investigational Site Number 616054, Bytom
Investigational Site Number 616052, Działdowo
Investigational Site Number 616057, Krakow
Investigational Site Number 616059, Krakow
Investigational Site Number 616005, Lublin
Investigational Site Number 616063, Myślenice
Investigational Site Number 616018, Poznan
Investigational Site Number 616013, Sosnowiec
Investigational Site Number 616056, Starachowice
Investigational Site Number 616016, Szczecin
Investigational Site Number 616058, Ustroń
Investigational Site Number 616051, Warsaw
Investigational Site Number 616053, Żyrardów
Investigational Site Number 642001, Bucharest
Investigational Site Number 642040, Bucharest
Investigational Site Number 642002, Bucharest
Investigational Site Number 710008, Pretoria
Investigational Site Number 710006, Pretoria
Investigational Site Number 410020, Busan
Investigational Site Number 410006, Busan
Investigational Site Number 410013, Daegu
Investigational Site Number 410011, Jeonju
Investigational Site Number 410005, Daejeon
Investigational Site Number 410016, Seoul
Investigational Site Number 410015, Seoul
Investigational Site Number 410022, Seoul
Investigational Site Number 410023, Seoul
Investigational Site Number 410021, Seoul
Investigational Site Number 410008, Suwon
Investigational Site Number 724011, Sabadell
Investigational Site Number 804025, Kiev
Investigational Site Number 804023, Kyiv
Investigational Site Number 804014, Kyiv
Investigational Site Number 804027, Kyiv
Investigational Site Number 826022, Birmingham
Investigational Site Number 826021, Dudley
Investigational Site Number 826020, Harlow
Investigational Site Number 826025, Wigan
Lead Sponsor
Regeneron Pharmaceuticals
INDUSTRY
Sanofi
INDUSTRY