LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2

PHASE3CompletedINTERVENTIONAL
Enrollment

2,067

Participants

Timeline

Start Date

January 15, 2013

Primary Completion Date

November 12, 2013

Study Completion Date

December 4, 2013

Conditions
Hyperlipidemia
Interventions
BIOLOGICAL

Evolocumab

Administered by subcutaneous injection

DRUG

Ezetimibe

Administered orally once a day

DRUG

Placebo to Evolocumab

Administered by subcutaneous injection

DRUG

Placebo to Ezetimibe

Administered orally once a day

DRUG

Atorvastatin

Administered orally once a day

DRUG

Rosuvastatin

Administered orally once a day

DRUG

Simvastatin

Administered orally once a day

Trial Locations (244)

100

Research Site, Taipei

807

Research Site, Kaohsiung City

1011

Research Site, Lausanne

1211

Research Site, Geneva

1449

Research Site, Alberton

1800

Research Site, Vilvoorde

2022

Research Site, Sydney

2196

Research Site, Johannesburg

2400

Research Site, Dunaújváros

2750

Research Site, Ballerup Municipality

2921

Research Site, Komárom

3065

Research Site, Fitzroy

3081

Research Site, Heidelberg Heights

3120

Research Site, Tremelo

3121

Research Site, Richmond

3200

Research Site, Gyöngyös

3300

Research Site, Eger

3500

Research Site, Hasselt

4032

Research Site, Chênée

4100

Research Site, Berettyóújfalu

5035

Research Site, Ashford

5063

Research Site, Fullarton

5100

Research Site, Jászberény

6500

Research Site, Baja

Research Site, Bellinzona

6800

Research Site, Hódmezővásárhely

7100

Research Site, Vejle

7130

Research Site, Somerset West

7405

Research Site, Cape Town

7580

Research Site, Kuils River

7624

Research Site, Pécs

8063

Research Site, Zurich

8370

Research Site, Blankenberge

8400

Research Site, Ostend

8596

Research Site, Muensterlingen

8700

Research Site, Marcali

9000

Research Site, Aalborg

9007

Research Site, Sankt Gallen

9200

Research Site, Mosonmagyaróvár

9301

Research Site, Bloemfontein

10367

Research Site, Berlin

10787

Research Site, Berlin

12627

Research Site, Hellersdorf

13104

Research Site, Manlius

13210

Research Site, Syracuse

14000

Research Site, Mexico City

14033

Research Site, Caen

14221

Research Site, Williamsville

14609

Research Site, Rochester

15216

Research Site, Pittsburgh

16635

Research Site, Duncansville

17405

Research Site, York

20162

Research Site, Milan

21034

Research Site, Dijon

21201

Research Site, Baltimore

22601

Research Site, Winchester

23435

Research Site, Suffolk

27103

Research Site, Winston-Salem

28007

Research Site, Madrid

28029

Research Site, Madrid

28223

Research Site, Pozuelo de Alarcón

Research Site, Pozuelo de Alarcón

29200

Research Site, Brest

29501

Research Site, Florence

30328

Research Site, Atlanta

30342

Research Site, Atlanta

32117

Research Site, Daytona Beach

32223

Research Site, Jacksonville

32901

Research Site, Melbourne

33173

Research Site, Miami

33952

Research Site, Port Charlotte

34149

Research Site, Trieste

34270

Research Site, Durango

34295

Research Site, Montpellier

35128

Research Site, Padua

35294

Research Site, Birmingham

37520

Research Site, León

38301

Research Site, Jackson

38305

Research Site, Jackson

38801

Research Site, Tupelo

39104

Research Site, Magdeburg

40138

Research Site, Bologna

41017

Research Site, Crestview Hills

43302

Research Site, Marion

43907

Research Site, Cadiz

44093

Research Site, Nantes

44100

Research Site, Guadalajara

44124

Research Site, Ferrara

44130

Research Site, Guadalajara

44708

Research Site, Canton

44870

Research Site, Sandusky

44906

Research Site, Mansfield

45219

Research Site, Cincinnati

45227

Research Site, Cincinnati

45414

Research Site, Dayton

46010

Research Site, Valencia

46237

Research Site, Indianapolis

46320

Research Site, Hammond

46383

Research Site, Valparaiso

48197

Research Site, Ypsilanti

52242

Research Site, Iowa City

56124

Research Site, Pisa

57701

Research Site, Rapid City

58455

Research Site, Witten

59102

Research Site, Billings

64460

Research Site, Monterrey

66100

Research Site, Chieti

66421

Research Site, Homburg

67091

Research Site, Strasbourg

69120

Research Site, Heidelberg

71200

Research Site, Le Creusot

71203

Research Site, Monroe

73069

Research Site, Norman

75013

Research Site, Paris

75231

Research Site, Dallas

75571

Research Site, Paris

77074

Research Site, Houston

78229

Research Site, San Antonio

78240

Research Site, San Luis Potosí City

79106

Research Site, Freiburg im Breisgau

79189

Research Site, Bad Krozingen

80120

Research Site, Littleton

80131

Research Site, Napoli

83301

Research Site, Kaohsiung City

83704

Research Site, Boise

85306

Research Site, Glendale

85710

Research Site, Tucson

85712

Research Site, Tucson

86000

Research Site, Poitiers

88605

Research Site, Messkirch

89000

Research Site, Tampico

90509

Research Site, Torrance

90822

Research Site, Long Beach

91360

Research Site, Thousand Oaks

91361

Research Site, Westlake Village

91436

Research Site, Encino

92123

Research Site, San Diego

92663

Research Site, Newport Beach

92705

Research Site, Santa Ana

92780

Research Site, Tustin

95405

Research Site, Santa Rosa

95608

Research Site, Carmichael

98405

Research Site, Tacoma

121002

Research Site, Moscow

121552

Research Site, Moscow

127299

Research Site, Moscow

192242

Research Site, Saint Petersburg

194156

Research Site, Saint Petersburg

197022

Research Site, Saint Petersburg

197341

Research Site, Saint Petersburg

410054

Research Site, Saratov

630047

Research Site, Novosibirsk

650002

Research Site, Kemerovo

656055

Research Site, Barnaul

04210

Research Site, Auburn

04401

Research Site, Bangor

04101

Research Site, Portland

08043

Research Site, Voorhees Township

V5G 1T4

Research Site, Burnaby

V1Y 1E4

Research Site, Kelowna

V1Y 1V6

Research Site, Kelowna

V3V 1N1

Research Site, Surrey

A1A 3R5

Research Site, Saint John’s

N1R 6V6

Research Site, Cambridge

L8L 2X2

Research Site, Hamilton

N5W 6A2

Research Site, London

L3Y 5G8

Research Site, Newmarket

L1J 2K1

Research Site, Oshawa

N7T 4X3

Research Site, Sarnia

M1P 2T7

Research Site, Scarborough Village

M8V 3X8

Research Site, Toronto

M9V 4B4

Research Site, Toronto

N4S 5P5

Research Site, Woodstock

J4X 1S4

Research Site, Brossard

J4V 2G8

Research Site, Greenfield Park

H8S 2E4

Research Site, Lachine

J4N 0C9

Research Site, Longueuil

H4N 2W2

Research Site, Montreal

H9R 3J1

Research Site, Pointe-Claire

602 00

Research Site, Brno

603 00

Research Site, Brno

272 01

Research Site, Kladno

412 01

Research Site, Litoměřice

676 02

Research Site, Moravské Budějovice

775 20

Research Site, Olomouc

530 02

Research Site, Pardubice

120 00

Research Site, Prague

130 00

Research Site, Prague

140 21

Research Site, Prague

274 01

Research Site, Slaný

568 25

Research Site, Svitavy

562 18

Research Site, Ústí nad Orlicí

04103

Research Site, Leipzig

Unknown

Research Site, Hong Kong

Research Site, New Territories

09134

Research Site, Cagliari

06129

Research Site, Perugia

03800

Research Site, Mexico City

1066 EC

Research Site, Amsterdam

1105 AZ

Research Site, Amsterdam

1782 GZ

Research Site, Den Helder

9728 NT

Research Site, Groningen

7909 AA

Research Site, Hoogeveen

3435 CM

Research Site, Nieuwegein

6525 GA

Research Site, Nijmegen

3045 PM

Research Site, Rotterdam

5141 BM

Research Site, Waalwijk

3331 LZ

Research Site, Zwijndrecht

0140

Research Site, Lyttelton

0184

Research Site, Pretoria

120-752

Research Site, Seoul

135-710

Research Site, Seoul

138-736

Research Site, Seoul

443-380

Research Site, Suwon

443-721

Research Site, Suwon

04001

Research Site, AlmerÃ-a

Research Site, Almería

08003

Research Site, Barcelona

08036

Research Site, Barcelona

08907

Research Site, L'Hospitalet de Llobregat

701 46

Research Site, Ã-rebro

413 45

Research Site, Göteborg

222 21

Research Site, Lund

222 22

Research Site, Lund

171 45

Research Site, Stockholm

451 50

Research Site, Uddevalla

B15 2SQ

Research Site, Birmingham

FY3 7EN

Research Site, Blackpool

CF14 5GJ

Research Site, Cardiff

S40 4TF

Research Site, Chesterfield

PR7 7NA

Research Site, Chorley

DN9 1EP

Research Site, Doncaster

G20 0SP

Research Site, Glasgow

G45 9AW

Research Site, Glasgow

HA3 7LT

Research Site, Harrow

L22 0LG

Research Site, Liverpool

L7 8XP

Research Site, Liverpool

M13 9WL

Research Site, Manchester

M15 6SX

Research Site, Manchester

RG2 0FT

Research Site, Reading

RG2 0TG

Research Site, Reading

DN15 7BH

Research Site, Scunthorpe

WF1 4DG

Research Site, Wakefield

YO21 1SD

Research Site, Whitby

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY