402
Participants
Start Date
July 12, 2013
Primary Completion Date
December 1, 2015
Study Completion Date
June 4, 2019
MEK162
MEK162 will be administered as a fixed dose of 45 mg (3 x 15 mg tablets) BID, with a glass of water and taken with or without food.
Dacarbazine
Patients randomized to dacarbazine will receive an IV infusion of dacarbazine 1000 mg/m2 over the course of 1 hour on day 1 and then every three weeks.
Chris O'Brien Lifehouse Hospital, Camperdown
Melanoma Institute Australia, North Sydney
Sint-Augustinuskliniek, Wilrijk
Severance Hospital Yonsei University Health System - PPDS, Seoul
Princess Alexandra Hospital, Woolloongabba
Charite Campus Mitte, Berlin
A.O.U. Città della Salute e della Scienza di Torino - Presidio S. Lazzaro, Torino
Hopitaux de La Timone, Marseille
Hospital Universitario A Coruña, A Coruña
IRCCS Az. Osp. Universitaria San Martino- IST, Genova
Penn State Milton S. Hershey Medical Center, Hershey
Cancer Center Associates - Medical Oncology, Bethlehem
St. Luke's University Hospital - Bethlehem Campus, Bethlehem
St. Luke's Cancer Center - Anderson Campus, Easton
Cancer Center Associates - Medical Oncology, Allentown
St. Luke's Cancer Center - Allentown Campus, Allentown
St. Luke's Hospital - Allentown Campus, Allentown
St. Luke's Hospital - Quakertown Campus, Quakertown
Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia
Thomas Jefferson Medical Oncology, Philadelphia
Thomas Jefferson University, Philadelphia
Ospedale San Raffaele S.r.l. - PPDS, Milan
Fondazione IRCCS 'Istituto Nazionale dei Tumori' di Milano, Milan
Harry and Jeannette Weinberg Cancer Institute @Franklin Square, Baltimore
Elben Klinken Stade Buxtehude, Buxtehude
Universitatsklinikum Schleswig-Holstein, Lübeck
Universitatsklinikum Schleswig-Holstein, Kiel
ASST Papa Giovanni XXIII - Azienda Ospedaliera Papa Giovanni XXIII, Bergamo
ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia, Brescia
Hospital General Universitario Gregorio Maranon, Madrid
MD Anderson Cancer Center, Madrid
Hospital Universitario Fundacion Jimenez Diaz, Madrid
Hospital Universitario HM Sanchinarro - CIOCC, Madrid
Hospital Regional Universitario de Malaga Hospital General, Málaga
Medizinische Hochschule Hannover (Hannover Medical School), Hanover
Clinica Universidad Navarra, Pamplona
Johannes Wesling Klinikum Minden, Minden
Florida Cancer Specialists, Gainesville
Florida Cancer Specialists, Altamonte Springs
Florida Cancer Specialists, Orange City
Florida Cancer Specialists, Tavares
Florida Cancer Specialists, Orlando
Hôpital Saint-André, Bordeaux
Florida Cancer Specialists, Brandon
Florida Cancer Specialists, Tampa
Florida Cancer Specialists, Tampa
Florida Cancer Specialists, St. Petersburg
Florida Cancer Specialists, St. Petersburg
Florida Cancer Specialists, Clearwater
Florida Cancer Specialists, Clearwater
Florida Cancer Specialists, Largo
Florida Cancer Specialists, Largo
Florida Cancer Specialists, Fort Myers
Florida Cancer Specialists, Fort Myers
Florida Cancer Specialists, Cape Coral
Florida Cancer Specialists, Port Charlotte
Istanbul University Cerrahpasa Medical Faculty Hospital, Istanbul
Florida Cancer Specialists, Naples
Florida Cancer Specialists, Naples
Florida Cancer Specialists, Bonita Springs
Florida Cancer Specialists, Bradenton
Florida Cancer Specialists, Sarasota
Florida Cancer Specialists, Sarasota
Florida Cancer Specialists, Venice
Florida Cancer Specialists, Venice
Florida Cancer Specialists, Inverness
Florida Cancer Specialists, Spring Hill
Florida Cancer Specialists, New Port Richey
Florida Cancer Specialists, Hudson
Complejo Hospitalario Universitario Insular - Materno Infantil, Gran Canaria
Ege University Medical Faculty, Bornova
Istituto Oncologico Veneto - I.R.C.C.S., Padua
Sarah Cannon Research Institute, Nashville
Hospital Universitario Virgen Macarena, Seville
The Ohio State University James Cancer Hospital, Columbus
The Ohio State University Martha Morehouse Medical Plaza, Columbus
Hospital Virgen de La Salud, Toledo
Universitätsklinikum Essen, Essen
Fundacion Instituto Valenciano de Oncologia, Valencia
Consorcio Hospital General Universitario de Valencia, Valencia
Goshen Center For Cancer Care, Goshen
Kresge Eye Institute, Bingham Farms
Fachklinik Hornheide, Münster
Barbara Ann Karmanos Cancer Institute, Detroit
Kresge Eye Institute, Detroit
Karmanos Cancer Institute of Farmington Hills, Farmington Hills
CHU Angers, Angers
Uniklinik Köln, Cologne
Hôpital Robert Debré, Reims
Azienza Ospedaliera Universitaria Senese, Siena
CHRU de Lille - Hôpital Huriet, Lille
Oncology Specialists, SC, Park Ridge
Institut für Diagnostische und Interventionelle Radiologie Frankfurt, Frankfurt am Main
Universitätsklinikum Frankfurt, Frankfurt am Main
Oncology Specialists, SC, Niles
Nebraska Methodist Hospital, Omaha
Klinikum Mannheim Universitätsklinikum gGmbH, Mannheim
University Clinic Heidelberg - PPDS, Heidelberg
Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer Rhône Alpes, Lyon
Service de PneumologieCHU Lyon Sud, Pierre-Bénite
IRCCS Giovanni Paolo II Istituto Oncologico, Bari
Centre Hospitalier Le Mans, Le Mans
Universitätsklinikum Tübingen, Tübingen
Highlands Oncology Group, Fayetteville
Highlands Oncology Group, Rogers
Hôpital Saint Louis, Paris
Elliot J. Ginchansky, MD, PA, Dallas
Dennis B. Kay, Dallas
Parkland Memorial Hospital, Dallas
UT Southwestern University Hospital- St. Paul, Dallas
Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas
UT Southwestern Medical Center at Dallas, Dallas
UT Southwestern University Hospital - Zale Lipshy, Dallas
Centre Hospitalier Universitaire Hopitaux de Rouen, Rouen
US Oncology, The Woodlands
Texas Oncology-Austin Central, Austin
Universitaetsklinikum Freiburg, Freiburg im Breisgau
Istituto Nazionale per lo studio e la cura dei tumori Fondazione Giovanni Pascale, Napoli
AOU dell'Università degli Studi della Campania Luigi Vanvitelli, Napoli
LMU Klinikum der Universität München, München
Universit*ätsklinikum Ulm, Ulm
Klinikum Nuernberg Nord, Nuremberg
Hadassah Medical Center - PPDS, Jerusalem
Centre Hospitalier Universitaire Ambroise Pare, Boulogne-Billancourt
University Clinic Regensburg - PPDS, Regensburg
Universitätsklinikum Würzburg, Würzburg
OHSU Knight Cancer Institute, Portland
Kaiser Permanente Northwest Region Oncology/Hematology, Portland
OHSU Center for Health and Healing, Portland
OHSU, Portland
Oregon Health and Science University, Portland
Helios Klinikum Erfurt, Erfurt
Russian Oncology Research Center n a N N Blokhin, Moscow
Scientific Research Institute of Oncology n.a. N.N. Petrov, Saint Petersburg
Ryazan Regional Clinical Oncology Dispensary, Ryazan
National Cancer Center Hospital, Chūōku
Rambam Medical Center - PPDS, Haifa
Sheba Medical Center - PPDS, Ramat Gan
INCA Instituto Nacional de Cancer, Rio de Janeiro
Eastern Maine Medical Center, Bangor
Massachusetts General Hospital, Boston
Brigham and Women's Hospital, Boston
Dana Farber Cancer Institute, Boston
Hackensack University Medical Center, Hackensack
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack
Cooper University Hospital, Voorhees Township
US Oncology, Fort Worth
Sanatorio de La Providencia, Buenos Aires
Centro de Investigación Clínica ? Clínica Viedma, Viedma
Centro Oncologico de Rosario, Rosario
Fundacion CIDEA, Buenos Aires
Lake Macquarie Private Hospital, Gateshead
Royal Adelaide Hospital, Adelaide
LKH-Universitätsklinikum Klinikum Graz, Graz
Hospital Clinic de Barcelona, Barcelona
Universitätsklinikum Innsbruck, Innsbruck
Salzburger Landeskliniken, Salzburg
Allgemeines Krankenhaus der Stadt Wien, Vienna
UZ Gasthuisberg, Leuven
CHU Sart Tilman, Liège
Hospital de Clinicas de Passo Fundo, Passo Fundo
Hospital Moinhos de Vento, Porto Alegre
Hospital Moinhos de Vento, Porto Alegre
Hospital São José, São Paulo
Alberta Health Services - Cross Cancer Institute, Edmonton
London Regional Cancer Program, London
Sunnybrook Research Institute Centre, Toronto
Princess Margaret Cancer Centre, Toronto
McGill University Health Center / Royal Victoria Hospital, Montreal
CHU de Quebec - L'Hotel-Dieu de Quebec, Québec
Mou/Mmci - Ppds, Brno
Fakultni nemocnice Ostrava, Ostrava
Fakultni nemocnice Kralovske Vinohrady, Prague
Vseobecna Fakultni Nemocnice V Praze, Prague
Groupe Hospitalier Archet I Et II, Nice
Universitatsklinikum Leipzig, Leipzig
Klinikum Dorothea Christiane Erxleben Quedlinburg GmbH, Quedlinburg
Universitätsklinikum Carl Gustav Carus an der TU Dresden, Dresden
SRH Wald-Klinikum Gera GmbH, Gera
Laiko General Hospital of Athens, Athens
Magyar Honvédség Egészségügyi Központ, Budapest
Orszagos Onkologiai Intezet, Budapest
Somogy Megyei Kaposi Mór Oktató Kórház, Kaposvár
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet, Szolnok
Istituto Dermopatico dell'Immacolata IRCCS, Rome
Istituto Nazionale Tumori Regina Elena, Roma
Shinshu University Hospital, Matsumoto
Kansai Medical University Hospital, Hirakata
Radboud University Nijmegen Medical Centre, Nijmegen
Het Nederlands Kanker Instituut Antoni Van Leeuwenhoek Ziekenhuis, Amsterdam
Leids Universitair Medisch Centrum, Leiden
Isala Klinieken, Zwolle
Centrum Medyczne MAVIT Sp. z o.o., Warsaw
Lux Med, Warsaw
Centrum Onkologii Instytut im. Marii Sklodowskiej-Curie, Warsaw
Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E., Lisbon
Hospital Garcia de Orta*E.P.E., Almada
Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisbon
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS, Porto
Narodny onkologicky ustav, Bratislava
University of The Free State, Bloemfontein
Sandton Oncology Medical Group, Johannesburg
Sandton Oncology Medical Research, Johannesburg
Steve Biko Academic Hospital, Pretoria
Mary Potter Oncology Centre, Pretoria
Asan Medical Center - PPDS, Seoul
Samsung Medical Center - PPDS, Seoul
Seoul National University Hospital, Seoul
ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat
ICO l'Hospitalet - Hospital Duran i Reynals, Barcelona
Hospital Universitario Vall d'Hebrón - PPDS, Barcelona
Skanes Universitetssjukhus Lund, Lund
Skanes Universitetssjukhus Lund, Lund
Universitätsspital Zürich, Zurich
Hôpitaux Universitaires de Genève, Geneva
Centre Hospitalier Universitaire Vaudois, Lausanne
Adana Ba?kent Hastanesi K??la Yerle?kesi, Adana
Hacettepe University Medical Faculty, Ankara
Baskent University Medical Faculty Ankara Hospital, Ankara
Bristol Haematology and Oncology Centre, Bristol
Royal Cornwall Hospital, Truro
The Royal Sussex County Hospital, Brighton
Broomfield Hospital, Chelmsford
Singleton Hospital - PPDS, Swansea
Royal Preston Hospital, Preston
Royal Marsden Hospital - Surrey, London
Queen Elizabeth Hospital, Birmingham
St James s Institute of Clinical Oncology, Leeds
Clatterbridge Hospital, Metropolitan Borough of Wirral
Lead Sponsor
Pfizer
INDUSTRY