NCT01760005 - Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001 | Biotech Hunter

Enrollment

490

Participants

Timeline

Start Date

December 31, 2012

Primary Completion Date

April 30, 2028

Study Completion Date

July 31, 2028

Conditions

Alzheimers DiseaseDementiaAlzheimers Disease, Familial

Interventions

DRUG

Gantenerumab

Subcutaneously every 4 weeks at escalating doses

DRUG

Solanezumab

Intravenous infusion every 4 weeks at escalating doses

DRUG

Matching Placebo (Gantenerumab)

Subcutaneous injection of placebo every 4 weeks

DRUG

Matching Placebo (Solanezumab)

Intravenous infusion of placebo every 4 weeks

DRUG

Gantenerumab

Open-label administered Subcutaneously every 4 weeks at escalating doses

DRUG

E2814

Administered intravenously in a blinded fashion

DRUG

Lecanemab

Administered intravenously

DRUG

Matching Placebo (E2814)

Placebo administered intravenously in a blinded fashion.

Trial Locations (38)

2031

RECRUITING

Neuroscience Research Australia, Randwick

3010

RECRUITING

Mental Health Research Institute, Melbourne

6009

WITHDRAWN

The McCuster Foundation of Alzheimer's Disease Research, Nedlands

8036

RECRUITING

Hospital Clínic I Provincial de Barcelona, Barcelona

15213

RECRUITING

University of Pittsburgh, Pittsburgh

25125

RECRUITING

IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia

30329

RECRUITING

Emory University, Atlanta

31059

TERMINATED

CHU de Toulouse - Hôpital Purpan, Toulouse

35294

RECRUITING

University of Alabama in Birmingham, Birmingham

46202

RECRUITING

Indiana University School of Medicine, Indianapolis

50134

RECRUITING

Azienda Ospedaliera Universitaria Careggi, Florence

59037

TERMINATED

Hopital Roger Salengro - CHU Lille, Lille

60068

RECRUITING

Advocate Lutheran General Hospital, Park Ridge

63110

RECRUITING

Washington University in St. Louis, St Louis

69677

TERMINATED

Groupe Hospitalier Pitie-Salpetriere, Paris

TERMINATED

Hopital Neurologique Pierre Wertheimer, Bron

72076

RECRUITING

Universitaetsklinikum Tubingen, Tübingen

75231

RECRUITING

Kerwin Medical Center, Dallas

76031

TERMINATED

CHU de Rouen - Hôpital Charles Nicolle, Rouen

81377

RECRUITING

LMU-Campus Grosshadern, Munich

90033

RECRUITING

USC Keck School of Medicine, Los Angeles

92037

RECRUITING

University of California San Diego Medical Center, La Jolla

98195

RECRUITING

University of Washington, Seattle

06510

RECRUITING

Yale University School of Medicine, New Haven

02096

RECRUITING

Butler Hospital, Providence

C1428AQK

RECRUITING

Instituto de Investigaciones Neurologicas Raul Carrea, FLENI, Ciudad Autonoma de Buenos Aire

05403-000

RECRUITING

Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo

V6T 2B5

RECRUITING

UBC Hospital, Vancouver

M4N 3M5

RECRUITING

Sunnybrook Health Sciences Centre, Toronto

H4H 1R3

RECRUITING

McGill Center for Studies in Aging, Verdun

G1J 1Z4

RECRUITING

CHU de Quebec - Hôpital de l' Enfant Jésus, Québec

Unknown

RECRUITING

Grupo de Neurociencias Sede de la Universidad de Antioquia, Medellín

DUBLIN 4

RECRUITING

St Vincent's University Hospital, Dublin

951-8520

RECRUITING

Niigata University Medical & Dental Hospital, Niigata

113-8655

RECRUITING

University of Tokyo Hospital, Bunkyō City

1081 GM

RECRUITING

Brain Research Center, Amsterdam

00936

RECRUITING

University of Puerto Rico, School of Medicine, San Juan

WC1B 3BG

RECRUITING

The National Hospital for Neurology and Neurosurgery, London