A Study To Examine The Effects Of PF-04958242 On Ketamine-Induced Cognitive Impairment In Healthy Volunteers

PHASE1CompletedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

December 31, 2012

Primary Completion Date

February 28, 2014

Study Completion Date

February 28, 2014

Conditions
Schizophrenia
Interventions
DRUG

PF-04958242

PF-04958242, 0.35 mg orally administered capsule on Day 1 and 0.25 mg orally administered capsule on Days 2 - 5

DRUG

Ketamine

At 60 minutes after the 0.25 mg dose of PF-04958242 on Day 5, Ketamine (0.23 mg/kg over 1 minute, followed by a maintenance rate of 0.58 mg/kg/hr for 75 minutes) will be infused.

DRUG

Placebo

Placebo capsule orally administered on Days 1 - 5

DRUG

Ketamine

At 60 minutes after Placebo on Day 5, Ketamine (0.23 mg/kg over 1 minute, followed by a maintenance rate of 0.58 mg/kg/hr for 75 minutes) will be infused.

Trial Locations (2)

06511

Pfizer Investigational Site, New Haven

06516

Pfizer Investigational Site, West Haven

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Biogen

INDUSTRY