HaemoDYNAMICs in Primary and Secondary Hypertension

RecruitingOBSERVATIONAL
Enrollment

2,000

Participants

Timeline

Start Date

May 25, 2006

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Primary HypertensionSecondary HypertensionAortic StenosisRenal Insufficiency
Interventions
DRUG

Nitroglycerin 0.25 mg (single dose, no longer given since January 2017)

From the beginning of the study until the end of year 2016 a single dose of sublingual nitroglycerin was given to examine the associated acute haemodynamic effects (recordings completed).

DRUG

Salbutamol 400 µg (single dose, no longer given since January 2017)

From the beginning of the study until the end of year 2016 a 400 µg dose of inhaled salbutamol was given to examine the associated acute haemodynamic effects (recordings completed).

DRUG

L-arginine (10 min infusion, no longer given since January 2017)

From the beginning of the study until the end of year 2016 L-arginine infusion 10 mg/kg/min could be given for 10 minutes to examine acute haemodynamic effects (recordings completed).

DIETARY_SUPPLEMENT

Liquorice (2 weeks, glycyrrhizin 290-370 mg daily, no longer given since 2012)

Daily liquorice intake (daily glycyrrhizin dose 290-370 mg) for two weeks, measurements before and after intervention (recordings completed).

DIETARY_SUPPLEMENT

Small milk casein-derived polypeptides (12 weeks daily, recordings completed 2011)

Daily intake of yoghurt containing small milk casein-derived polypeptides (12 weeks) and placebo yoghurt (12 weeks), measurements before and after intervention (recordings completed 2011).

DRUG

Bisoprolol (5 mg daily for 3 weeks, recordings completed 2011)

Bisoprolol 5 mg daily for 3 weeks and placebo tablet daily for 3 weeks, double-blind, randomized, placebo-controlled cross-over protocol. Measurements before and after interventions (recordings completed 2011).

Trial Locations (2)

33014

RECRUITING

Tampere University, Tampere

33521

RECRUITING

Tampere University Hospital, Tampere

Sponsors
All Listed Sponsors
collaborator

Finnish Foundation for Cardiovascular Research

OTHER

collaborator

Paavo Nurmi Foundation

UNKNOWN

collaborator

Sigrid Jusélius Foundation

OTHER

collaborator

Finnish Cultural Foundation

OTHER

collaborator

Tampere Tuberculosis Foundation

OTHER

collaborator

Medical Research Fund of the Tampere University Hospital, Finland

OTHER

collaborator

Aarne Koskelo Foundation

OTHER

collaborator

Finnish Medical Foundation

NETWORK

collaborator

Finnish Kidney Foundation

UNKNOWN

collaborator

Päivikki and Sakari Sohlberg Foundation, Finland

OTHER

lead

Tampere University

OTHER