666
Participants
Start Date
February 22, 2013
Primary Completion Date
February 26, 2016
Study Completion Date
November 9, 2023
PD-0332991
PD-0332991, 125mg, orally once daily on Day 1 to Day 21 of every 28-day cycle followed by 7 days off treatment
Letrozole
Letrozole, 2.5mg, orally once daily (continuously)
Placebo
Placebo, 125mg, orally once daily on Day 1 to Day 21 of every 28-day cycle followed by 7 days off treatment
Letrozole
Letrozole, 2.5mg, orally once daily (continuously)
St. James Hospital, Dublin
Beaumont Hospital, Dublin
Institut Jules Bordet, Brussels
Szent Margit Korhaz, Budapest
Affidea Diagnosztika Kft., Budapest
UZ Brussel, Brussels
Orszagos Onkologiai Intezet ,, Budapest
Oncologie, Brussels
St Vincent's Hospital Sydney, Darlinghurst
Calvary Mater Newcastle, Waratah
Laverty Pathology, Port Macquarie
Mid North Coast Diagnostic Imaging, Port Macquarie
Gasthuis Zusters Antwerpen - Campus Sint- Augustinus, Wilrijk
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg, Leuven
Royal Melbourne Hospital, Parkville
Northern Hospital, Epping
Epworth Healthcare, Richmond
Maroondah Hospital, Ringwood East
Bendigo Health Care Group, The Bendigo Hospital Campus, Bendigo
Goulburn Valley Health, Shepparton
CHU Start Tilman, Liège
Icon Cancer Care, Auchenflower
Icon Cancer Care Corporate Office, South Brisbane
Princess Alexandra Hospital, Woolloongabba
Josa Andras Teaching Hospital,, Nyíregyháza
Sunshine Coast University Hospital, Birtinya
CHR East Belgium - Verviers, Verviers
Royal Adelaide Hospital, Adelaide
Grand Hopital de Charleroi / Service d'Hematologie et Oncologie, Charleroi
Fiona Stanley Hospital, Murdoch
Szegedi Tudomanyegyetem Altalanos Orvosi Kar, Patologia Intezet, Szeged
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Altalanos Orvostudomanyi Kar, Szeged
Diagnoscan Magyarorszag Kft., Szeged
Petz Aladar Megyei Oktato Korhaz, Onkoradiologiai Osztaly, Győr
National Taiwan University Hospital, Taipei
Columbia University Medical Center, New York
National Cancer Center, Center for Breast Cancer, Goyang-si
Mackay Memory Hospital, Taipei
CareMount Medical, Brewster
CareMount Medical, Mount Kisco
Northern Westchester Hospital, Mount Kisco
Veterans General Hospital-Taipei, Taipei
Seoul National University Bundang Hospital, Seongnam-si
Centre François Baclesse, Caen
Centro Oncologico de Galicia, A Coruña
MedStar Georgetown University Hospital, Washington D.C.
Hospital de Donostia, Donostia / San Sebastian
IRCCS - Istituto Europeo di Oncologia, Milan
Universitaetsklinikum Hamburg-Eppendorf, Hamburg
Centre Georges François Leclerc, Dijon
University of Maryland, Greenebaum Cancer Center, Baltimore
Shenandoah Oncology PC, Winchester
Complejo Hospitalario de Jaen, Jaén
Virginia Oncology Associates, Virginia Beach
Virginia oncology Associates, Norfolk
Virginia Oncology Associates, Newport News
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Roanoke
Oncology & Hematology Associates of Southwest Virginia, INC., D.B.A. Blue Rigde Cancer Care, Blacksburg
Universitatsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Gynakologie und Geburtshilfe, Kiel
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Salem
Oncology & Hematology Associates of Southwest Virginia, INC., D.B.A. Blue Rigde Cancer Care, Wytheville
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Low Moor
Hospital Universitario Arnau de Vilanova de Lleida, Lleida
WVU Medicine, Morgantown
Hospital General Universitario Gregorio Marañon, Madrid
Centro Oncologico MD Anderson Internacional España, Madrid
Hospital Clinico San Carlos, Madrid
HOSPITAL Universitario 12 DE OCTUBRE, Madrid
Hospital Madrid Universitario Sanchinarro, Madrid
Hospital Universitario Fundacion de Alcorcon, Alcorcón
Northwest Georgia Oncology Centers, PC, Marietta
Grady Health System, Atlanta
Emory University Hospital Midtown, Atlanta
Emory University Hospital, Atlanta
The Emory Clinic, Atlanta
Winship Cancer Institute, Atlanta
Institut Claudius Regaud- Cancer Comprehensive Center- IUCT-O-Medical Oncology Department, Toulouse Cedex-9
Cancer Specialists of North Florida - St. Augustine, Saint Augustine
Cancer Specialist of North Florida, Pharmacy, Jacksonville
Cancer Specialists of North Florida-Southpoint, Jacksonville
Orlando Health, Inc., Orlando
Memorial Breast Cancer Center at Memorial Regional Hospital, Hollywood
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood
Memorial Regional Hospital, Hollywood
Memorial Breast Cancer Center at Memorial Hospital West, Pembroke Pines
Memorial Cancer Institute at Memorial Hospital West, Pembroke Pines
Memorial Hospital West, Pembroke Pines
Sylvester Comprehensive Cancer Center Plantation, Plantation
Sylvester at Deerfield Beach, Deerfield Beach
Centre Val d'Aurelle,, Montpellier
Centre Eugene Marquis, Rennes
Tennessee Oncology, PLLC, Dickson
Tennessee Oncology, PLLC, Gallatin
Tennessee Oncology PLLC, Franklin
Tennessee Oncology PLLC, Hermitage
Tennessee Oncology, PLLC, Lebanon
Tennessee Oncology PLLC, Murfreesboro
Tennessee Oncology, PLLC, Shelbyville
Tennessee Oncology PLLC, Smyrna
Sarah Cannon Research Institute, Nashville
Tennessee Oncology, PLLC, Nashville
Tennessee Oncology PLLC, Nashville
Tennessee Oncology PLLC, Nashville
Tennessee Oncology PLLC, Nashville
The West Clinic, PC dba West Cancer Centre, Memphis
The West Clinic, PC dba West Cancer Centre, Germantown
Hospital Universitario de Canarias, San Cristóbal de La Laguna
The West Clinic, PC dba West Cancer Centre, Southaven
The West Clinic, PC, Corinth
Universitaetsklinikum Magdeburg AOR Universitaetsfrauenklinik, Magdeburg
"Regional Municipal Establishment Sumy Regional Clinical Oncology Dispensary, Thoracic Department", Sumy
Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola-Malpighi, Bologna
James Graham Brown Cancer Center and University Hospital, Louisville
James Graham Brown Cancer Center, Louisville
Hospital Universitario Virgen Macarena, Seville
Hospital Universitario Virgen del Rocio, Seville
Institut de Cancérologie de l'Ouest-Rene Gauducheau, Saint-Herblain
Instituto Valenciano de Oncologia, Valencia
Irccs Irst, Meldola
University of Michigan Health System, Ann Arbor
Institut de Cancerologie de l'Ouest- Paul Papin, Anger Cedex 02
"MI Dnipropetrovsk City Multidisciplinary Clinical Hospital No.4 of the Dnipropetrovsk City Council", Dnipro
State Institution Dnipropetrovsk Medical Academy at the Ministry of Health of Ukraine, Dnipro
Klinikum Mutterhaus, Trier
Katholisches Klinikum Mainz, Mainz
Park Nicollet Frauenshuh Cancer Center, Saint Louis Park
Azienda Ospedaliero-Universitaria Pisana, Pisa
Presence Infusion Care- Skokie, Skokie
Presence Infusion Care- Evanston, Evanston
The Mark M. Connolly Center for Cancer and Specialty Care, Chicago
"Municipal Non-profit Enterprise Regional Centre of Oncology", Kharkiv
Carle Foundation Hospital DBA Carle Cancer Center, Urbana
Carle Foundation Hospital DBA Carle Cancer Center, Danville
Carle Foundation Hospital DBA Carle Cancer Center, Mattoon
Carle Foundation Hospital DBA Carle Cancer Center, Effingham
Mercy Clinic St. Louis Cancer and Breast Institute, Ballwin
Mercy Clinic St. Louis Cancer and Breast Institute, St Louis
Mercy Hospital St. Louis - David C. Pratt Cancer Center, St Louis
Mercy Hospital St. Louis, St Louis
Saint Francis Medical Center, Grand Island
Saint Francis Medical Center, Saint Francis Cancer Treatment Center, Grand Island
Saint Francis Medical Center, Hastings
"MI Zaporizhzhia Regional Clinical Oncology Dispensary Zaporizhzhia Regional Assembly,", Zaporizhzhia
"State institution Zaporizhzhia Medical Academy of Postgraduate Education MOH Ukraine,", Zaporizhzhya
Klinikverbund Sudwest - Kliniken Sidelfingen-Boblingen, Böblingen
US Oncology Investigational Products Center, Irving
Texas Oncology-Dallas Presbyterian Hospital, Dallas
Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas
Institut Curie, Departement d'Oncologie Medicale, Paris
Investigational Products Center (IPC), Fort Worth
The University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology, Houston
The University of Texas MD Anderson Cancer Center., Houston
The University of Texas MD Anderson Cancer Center, Houston
Lviv State Oncologic Regional Treatment and Diagnostic Center, Chemotherapy Department, Lviv
Texas oncology-west Texas, El Paso
Texas oncology-West Texas, El Paso
Texas Oncology-west Texas, El Paso
IOZ- Munchen, PGM- Studien GmbH, Munich
Rotkreuzklinikum Munchen, Frauenklinik,, Munich
Breast Cancer, University of Munich, Grosshadern Hospital, Munich
St. Mary's Hospital Regional Cancer Center, Grand Junction
Frauenklinik und Poliklinik Klinikum rechts der Isar, Technische Universitaet Muenchen, München
Azienda Ospedaliera San Giuseppe Moscati, Avellino
Kootenai Clinic Cancer Services, Coeur d'Alene
Kootenai Clinic Cancer Services, Post Falls
CHD Vendée, La Roche-sur-Yon
"Municipal Medical Institution Makiivka City Hospital No.2 of Donetsk Region", Makiivka
City Oncology Centre of Central Municipal Clinical Hospital, Uzhhorod
Institute of Postgraduate education and preuniversity preparing of Uzhgorod National Univ., Uzhhorod
Comprehensive Cancer Centers of Nevada, Henderson
Regulatory Office: Comprehensive Cancer Centers of Nevada Research Department, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
Los Angeles Hematology/Oncology Medical Group, Los Angeles
Southern California Permanente Medical Group, Los Angeles
Translational Research Management, Los Angeles
Administrative Address: UCLA Hematology/Oncology, Los Angeles
Drug Management Only: TRIO-US Pharmacy UCLA Medical Plaza, Attn: Steven L Wong, Pharm.D., Los Angeles
Regulatory Management Only: TRIO-US Central Administration, Los Angeles
Ronald Reagan UCLA Medical Center, Los Angeles
TRIO-US Central Administration: Regulatory Management Only, Los Angeles
TRIO-US Central Administration, Los Angeles
UCLA Hematology Oncology, Los Angeles
UCLA Hematology/Oncology, Los Angeles
Beverly Hills Cancer Center, Beverly Hills
Torrance Health Association, DBa Torrance Memorial Physician Network, Redondo Beach
UCLA Santa Monica Medical Center and Orthopaedic Hospital, Santa Monica
Southern California Permanente Medical Group, Bellflower
Universitatsklinikum Erlangen, Frauenklinik, Erlangen
UCLA Hematology/ Oncology- Pasadena, Pasadena
Los Angeles Hematology/Oncology Medical Group, Glendale
Wellness Oncology & Hematology, West Hills
UCLA Hematology/Oncology- Westlake, Westlake Village
Southern California Permanente Medical Group, San Diego
Hopital Rene Huguenin/Institut Curie, Saint-Cloud
UCLA Hematology/ Oncology- Irvine, Irvine
UCLA Hematology Oncology- Laguna Hills, Laguna Hills
St. Joseph Heritage Healthcare, Fullerton
San Luis Obispo Oncology and Hematology Health Center/ Pacific Central Coast Health Centers, San Luis Obispo
Central Coast Medical Oncology Corporation, Santa Maria
University of California, San Francisco, San Francisco
University of California San Francisco - Helen Diller Family Comprehensive Cancer Center, San Francisco
Institut Gustave Roussy, Villejuif
Northwest Cancer Specialists, PC, Portland
Kaiser Permanente Northwest Region, Portland
Northwest Cancer Specialists, P.C., Portland
OHSU Center for Health and Healing 2, Portland
OHSU Center for Health and Healing, Portland
OHSU Research Pharmacy Services, Portland
Oregon Health and Science University, Portland
Seattle Cancer Care Alliance, Seattle
Northwest Cancer Specialists, P.C., Vancouver
Northwest Cancer Specialists P.C., Vancouver
Federal State Budget Institution, Moscow
State Budget Healthcare Institution Moscow City Oncology Hospital, Moscow Area
"State Budget Healthcate Institution Leningrad Region Oncology Dispensary", Kuzmolovo
"Non-State Health Care agency Road Clinical Hospital of PLC Russian Railways", Saint Petersburg
Saint-Petersburg State Budget Healthcare Institution (SBHCI), Saint Petersburg
Regional Budgetary Healthcare Institution Kursk Regional Clinical, Kursk
Ryazan Regional Clinical Oncology Dispensary, Ryazan
GUZ Republic Clinical Oncology Dispensary of Ministry of Health of Republic of Tatarstan, Kazan'
Republican Clinical Hospital n.a. G.G. Kuvatov, Ufa
State Budget Medical Institution Republican Clinical Oncology, Ufa
SBHI of Republic of Bashkortostan Emergency Hospital, Ufa
Budget Institution of Healthcare, Omsk
Budget Institution of Healthcare, Omsk
Drug Management Only: UCLA West Medical Pharmacy, Attn: Steven L Wong, Pharm.D., Los Angeles
UCLA West Medical Pharmacy, Attn: Steven L. Wong, Los Angeles
UCLA West Medical Pharmacy: Drug Management Only, Los Angeles
UCLA West Medical Pharmacy; Drug Management Only, Los Angeles
UCLA West Medical Pharmacy, Los Angeles
Stanford Women's Cancer Center, Stanford
Smilow Cancer Hospital at Yale New Haven, New Haven
Whittingham Cancer Center @ Norwalk Hospital, Norwalk
Walter Reed National Military Medical Center, Bethesda
Comprehensive Cancer Centers of Nevada, Henderson
Stony Brook University- Cancer Center, Stony Brook
University of Wisconsin, Madison
Tom Baker Cancer Centre, Calgary
Cross Cancer Institute, Edmonton
BC Cancer Agency-Fraser Valley Centre, Surrey
British Columbia Cancer Agency-Vancouver Centre, Vancouver
QEII Health Sciences Centre, Victoria General Site, Halifax
London Regional Cancer Program, London
Southlake Regional Health Centre- Stronach Regional Cancer Centre, Newmarket
Sunnybrook Research Institute, Toronto
St. Michaels Hospital, Toronto
Princess Margaret Cancer Centre, Toronto
McGill University Health Centre (MUHC), Glen Site, Cedars Cancer Centre, Montreal
Hopital du Sacre-Coeur, Montreal
Center Hospitalier Affilie Universitaire de Quebec, Universite Laval, Hopital du Saint Sacrement, Québec
Allan Blair Cancer Centre, Regina
Fakultni nemocnice Hradec Kralove, Klinika onkologie a radiologie, Hradec Králové
Centre Antoine Lacassagne, Nice
University Hospital Carl Gustav Carus - Department for Obstetrics and Gynecology., Dresden
"Országos Onkológiai Intézet B Belgyogyaszati osztaly", Budapest
Országos Onkológiai Intézet, Nuklearis Medicina Osztaly, Budapest
Országos Onkológiai Intézet, Radiologiai Diagnosztikai Osztily, Budapest
Bon Secours Hospital, Cork
St Vincents University Hospital, Dublin
Department of Medical Oncology, Galway
Mid Western Regional Hospital, Limerick
Waterford Regional Hospital, Waterford
Mater Misericordiae University Hospital, Dublin
Istituti Fisioterapici Ospitalieri, Roma
Ospedale SS Trinita, Sora (FR)
Aichi Cancer Center Hospital, Nagoya
National Cancer Center Hospital East, Kashiwa
National Hospital Organization Shikoku Cancer Center, Matsuyama
National Hospital Organization Hokkaido Cancer Center, Sapporo
Kumamoto City Hospital, Kumamoto
Saitama Cancer Center, Kita-adachi-gun
National Cancer Center Hospital, Chuo-Ku
Chiba Cancer Center, Chiba
National Hospital Organization Kyushu Cancer Center, Fukuoka
Hiroshima City Hiroshima Citizens Hospital, Hiroshima
Hakuaikai Medical Corporation Sagara Hospital, Kagoshima
Kumamoto University Hospital, Kumamoto
Niigata Cancer Center Hospital 2-15-3, Niigata
Iwate Medical University Hospital, Numakunai
National Hospital Organization Osaka National Hospital, Osaka
Europejskie Centrum Zdrowia Otwock, Otwock
Oncology and Radiotherapy Clinic, Gdansk
"Niepubliczny Zakład Opieki Zdrowotnej Onko-Dent SP.P. G.L. Słomian", Żory
Severance Hospital, Yonsei University Health System, Seodaemun-gu
Seoul National University Hospital / Department of Internal Medicine, Seoul
Asan Medical Center, Division of Oncology, Department of Internal Medicine, Seoul
Samsung Medical Center, Division of Hematology-Oncology, Department of Medicine, Seoul
Hospital Universitari Son Espases, Palma de Mallorca
Hospital Universitari Germans Trias i Pujol, Badalona
Consorci Sanitari de Terrassa, Terrassa
Hospital Universitario Infanta Cristina, Badajoz
Hospital del Mar, Barcelona
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic I Provincial, Barcelona
Instituto Catalan de Oncologia L'Hospitalet, L'Hospitalet de Llobregat (Barcelona)
Kent Oncology Center, Maidstone
Edinburgh Cancer Centre, Western General Hospital, Edinburgh
Beatson Institute for Cancer Research, Glasgow
Guys Hospital, London
The Royal Marsden NHS Foundation Trust, London
Charing Cross Hospital, London
Christie Hospital NHS Foundation Trust, Manchester
The Research And Development Office, The Christie NHS Foundation Trust, Manchester
Lead Sponsor
Pfizer
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