Free DNA and Nucleosome Concentrations in Pathological Pregnancies

CompletedOBSERVATIONAL
Enrollment

137

Participants

Timeline

Start Date

June 30, 2015

Primary Completion Date

December 17, 2018

Study Completion Date

December 17, 2018

Conditions
PregnancyVenous ThrombosisPulmonary EmbolismHypertension, Pregnancy-InducedEclampsiaHELLP SyndromePre-EclampsiaFetal DeathPlacental Insufficiency
Interventions
BIOLOGICAL

Bloodwork, baseline

36 ml of blood are drawn at baseline (last month of pregnancy for groups P and T2, inclusion for group T1) in order to quantify the following: plasma free DNA concentration, plasma nucleosome concentration, hemoglobin, platelets, leukocytes, polynuclear neutrophils, mean corpuscular volume, monocytes, mean corpuscular hemoglobin, lymphocytes, polynuclear eosinophils, polynuclear basophils, D-Dimers, Fibrin monomers, Trophoblast microparticles, Angiogenic marker CD146.

BIOLOGICAL

Blood work, Months 1 & 2

36 ml of blood are drawn at 1 \& 2 months after inclusion in order to quantify the following: plasma free DNA concentration, plasma nucleosome concentration, hemoglobin, platelets, leukocytes, polynuclear neutrophils, mean corpuscular volume, monocytes, mean corpuscular hemoglobin, lymphocytes, polynuclear eosinophils, polynuclear basophils, D-Dimers, Fibrin monomers, Trophoblast microparticles, Angiogenic marker CD146.

BIOLOGICAL

Bloodwork, Months -1 to -6

36 ml of blood are drawn at the third, fourth, fifth, sixth, seventh and eight months of normal pregnancy (corresponding to months -1 to -6 before comparative baseline; this group is included in the study early during pregnancy)in order to quantify the following: plasma free DNA concentration, plasma nucleosome concentration, hemoglobin, platelets, leukocytes, polynuclear neutrophils, mean corpuscular volume, monocytes, mean corpuscular hemoglobin, lymphocytes, polynuclear eosinophils, polynuclear basophils, D-Dimers, Fibrin monomers, Trophoblast microparticles, Angiogenic marker CD146.

Trial Locations (1)

30029

CHU de Nîmes - Hôpital Universitaire Carémeau, Nîmes

All Listed Sponsors
lead

Centre Hospitalier Universitaire de Nīmes

OTHER

NCT01736826 - Free DNA and Nucleosome Concentrations in Pathological Pregnancies | Biotech Hunter | Biotech Hunter