Erlotinib Hydrochloride and Cabozantinib-s-Malate Alone or in Combination as Second or Third Line Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

125

Participants

Timeline

Start Date

February 13, 2013

Primary Completion Date

August 14, 2015

Study Completion Date

March 18, 2026

Conditions
Recurrent Lung Non-Small Cell CarcinomaStage IV Lung Non-Small Cell Cancer AJCC v7
Interventions
DRUG

Cabozantinib S-malate

Given PO

DRUG

Erlotinib Hydrochloride

Given PO

OTHER

Laboratory Biomarker Analysis

Correlative studies

Trial Locations (360)

10461

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

10601

Dickstein Cancer Treatment Center, White Plains

11794

Stony Brook University Medical Center, Stony Brook

16505

UPMC Hillman Cancer Center Erie, Erie

16801

Geisinger Medical Group, State College

17403

WellSpan Health-York Hospital, York

17602

Lancaster General Hospital, Lancaster

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

17901

Geisinger Cancer Services-Pottsville, Pottsville

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

18840

Guthrie Medical Group PC-Robert Packer Hospital, Sayre

18901

Doylestown Hospital, Doylestown

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Medical Center, Wynnewood

Main Line Health NCORP, Wynnewood

19107

Thomas Jefferson University Hospital, Philadelphia

19141

Einstein Medical Center Philadelphia, Philadelphia

19301

Paoli Memorial Hospital, Paoli

19713

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

Beebe Medical Center, Lewes

19971

Beebe Health Campus, Rehoboth Beach

19973

TidalHealth Nanticoke / Allen Cancer Center, Seaford

21204

Greater Baltimore Medical Center, Baltimore

21921

Christiana Care - Union Hospital, Elkton

22401

Fredericksburg Oncology Inc, Fredericksburg

25304

West Virginia University Charleston Division, Charleston

26003

Wheeling Hospital/Schiffler Cancer Center, Wheeling

26506

West Virginia University Healthcare, Morgantown

30033

Atlanta VA Medical Center, Decatur

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

31201

Atrium Health Navicent, Macon

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

43015

Delaware Health Center-Grady Cancer Center, Delaware

Delaware Radiation Oncology, Delaware

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

Newark Radiation Oncology, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

43215

Columbus NCI Community Oncology Research Program, Columbus

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43402

Toledo Clinic Cancer Centers-Bowling Green, Bowling Green

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

43560

ProMedica Flower Hospital, Sylvania

43567

Fulton County Health Center, Wauseon

43606

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

43608

Mercy Health - Saint Vincent Hospital, Toledo

43614

University of Toledo, Toledo

43616

Saint Charles Hospital, Oregon

Toledo Clinic Cancer Centers-Oregon, Oregon

43617

Toledo Community Hospital Oncology Program CCOP, Toledo

43623

Mercy Health - Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44304

Summa Health System - Akron Campus, Akron

44708

Cleveland Clinic Mercy Hospital, Canton

44883

Mercy Hospital of Tiffin, Tiffin

45504

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45714

Strecker Cancer Center-Belpre, Belpre

45750

Marietta Memorial Hospital, Marietta

45801

Saint Rita's Medical Center, Lima

45804

Lima Memorial Hospital, Lima

46202

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

46219

IU Health Central Indiana Cancer Centers-East, Indianapolis

46350

IU Health La Porte Hospital, La Porte

46360

Franciscan Saint Anthony Health-Michigan City, Michigan City

Woodland Cancer Care Center, Michigan City

46391

Michiana Hematology Oncology PC-Westville, Westville

46514

Michiana Hematology Oncology PC-Elkhart, Elkhart

46515

Elkhart General Hospital, Elkhart

46545

Michiana Hematology Oncology PC-Mishawaka, Mishawaka

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

46563

Michiana Hematology Oncology PC-Plymouth, Plymouth

46601

Memorial Hospital of South Bend, South Bend

46617

South Bend Clinic, South Bend

46628

Northern Indiana Cancer Research Consortium, South Bend

46904

Community Howard Regional Health, Kokomo

47303

IU Health Ball Memorial Hospital, Muncie

47408

IU Health Bloomington, Bloomington

48060

Lake Huron Medical Center, Port Huron

48093

Henry Ford Health Warren Hospital, Warren

48106

Michigan Cancer Research Consortium NCORP, Ann Arbor

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48124

Corewell Health Dearborn Hospital, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48162

Mercy Memorial Hospital, Monroe

Toledo Clinic Cancer Centers-Monroe, Monroe

48236

Henry Ford Health Saint John Hospital, Detroit

48341

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

MyMichigan Medical Center Saginaw, Saginaw

48912

University of Michigan Health - Sparrow Lansing, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49048

Beacon Kalamazoo, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49201

Allegiance Health, Jackson

49221

Bixby Medical Center, Adrian

Hickman Cancer Center, Adrian

49829

OSF Saint Francis Hospital and Medical Group, Escanaba

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Iowa-Wide Oncology Research Coalition NCORP, Des Moines

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50401

Mercy Medical Center - North Iowa, Mason City

51101

Siouxland Regional Cancer Center, Sioux City

51102

Mercy Medical Center-Sioux City, Sioux City

51104

Saint Luke's Regional Medical Center, Sioux City

52403

Mercy Hospital, Cedar Rapids

Oncology Associates at Mercy Medical Center, Cedar Rapids

52722

Constantinou, Costas L MD (UIA Investigator), Bettendorf

53038

University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53081

HSHS Saint Nicholas Hospital, Sheboygan

53188

ProHealth Waukesha Memorial Hospital, Waukesha

53226

Medical College of Wisconsin, Milwaukee

53715

SSM Health Dean Medical Group - South Madison Campus, Madison

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54017

Cancer Center of Western Wisconsin, New Richmond

54143

Bay Area Medical Center, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54221

Holy Family Memorial Hospital, Manitowoc

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54401

Marshfield Clinic-Wausau Center, Wausau

54449

Marshfield Medical Center-Marshfield, Marshfield

Marshfield Medical Center, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54481

Aspirus Cancer Care - Stevens Point, Stevens Point

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54501

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

Saint Mary's Hospital, Rhinelander

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

HSHS Sacred Heart Hospital, Eau Claire

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire

54729

Marshfield Clinic-Chippewa Center, Chippewa Falls

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55082

Lakeview Hospital, Stillwater

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

56601

Sanford Joe Lueken Cancer Center, Bemidji

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

Hematology Oncology Associates of Illinois-Highland Park, Highland Park

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60048

AMG Libertyville - Oncology, Libertyville

60076

Hematology Oncology Associates of Illinois - Skokie, Skokie

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60426

Ingalls Memorial Hospital, Harvey

60504

Rush-Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

60611

Northwestern University, Chicago

60714

Illinois Cancer Specialists-Niles, Niles

60901

Presence Saint Mary's Hospital, Kankakee

61104

Swedish American Hospital, Rockford

61114

UW Health Carbone Cancer Center Rockford, Rockford

61265

Garneau, Stewart C MD (UIA Investigator), Moline

Porubcin, Michael MD (UIA Investigator), Moline

Spector, David MD (UIA Investigator), Moline

Trinity Medical Center, Moline

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

Ottawa Regional Hospital and Healthcare Center, Ottawa

61354

Illinois CancerCare-Peru, Peru

Illinois Valley Hospital, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61462

Illinois CancerCare-Monmouth, Monmouth

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin, Pekin

61614

Proctor Hospital, Peoria

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

OSF Saint Joseph Medical Center, Bloomington

61704

Illinois CancerCare-Bloomington, Bloomington

61761

Carle Cancer Institute Normal, Normal

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

Heartland Cancer Research NCORP, Decatur

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

63703

Saint Francis Medical Center, Cape Girardeau

66044

Lawrence Memorial Hospital, Lawrence

66502

Cancer Center of Kansas-Manhattan, Manhattan

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

Wichita NCI Community Oncology Research Program, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67801

Cancer Center of Kansas - Dodge City, Dodge City

67905

Cancer Center of Kansas-Liberal, Liberal

68106

Missouri Valley Cancer Consortium, Omaha

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Nebraska Cancer Research Center, Lincoln

70115

Ochsner Baptist Medical Center, New Orleans

70121

Ochsner Medical Center Jefferson, New Orleans

70809

Ochsner Health Center-Summa, Baton Rouge

75708

University of Texas Health Science Center at Tyler, Tyler

78229

Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio

University of Texas Health Science Center at San Antonio, San Antonio

78701

Dell Seton Medical Center at The University of Texas, Austin

80012

The Medical Center of Aurora, Aurora

80111

Rocky Mountain Cancer Centers-Greenwood Village, Greenwood Village

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Swedish Medical Center, Englewood

80122

AdventHealth Littleton, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

Sky Ridge Medical Center, Lone Tree

80138

AdventHealth Parker, Parker

Rocky Mountain Cancer Centers-Parker, Parker

80210

AdventHealth Porter, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

Saint Joseph Hospital - Cancer Centers of Colorado, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

Rose Medical Center, Denver

80222

Western States Cancer Research NCORP, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80303

Boulder Community Foothills Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80401

Mountain Blue Cancer Care Center, Golden

Intermountain Health Lutheran Hospital, Wheat Ridge

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80539

Banner McKee Medical Center, Loveland

80631

Banner North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81008

Rocky Mountain Cancer Centers - Pueblo, Pueblo

81301

Mercy Medical Center, Durango

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

85259

Mayo Clinic in Arizona, Scottsdale

87106

University of New Mexico Cancer Center, Albuquerque

88011

Memorial Medical Center-Las Cruces, Las Cruces

89052

Cancer and Blood Specialists-Henderson, Henderson

Comprehensive Cancer Centers of Nevada - Henderson, Henderson

Las Vegas Cancer Center-Henderson, Henderson

89074

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson

Oncology Las Vegas - Henderson, Henderson

89102

University Medical Center of Southern Nevada, Las Vegas

89106

Cancer and Blood Specialists-Shadow, Las Vegas

Radiation Oncology Centers of Nevada Central, Las Vegas

89109

GenesisCare USA - Las Vegas, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas

89113

HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas

89119

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89120

Nevada Cancer Research Foundation NCORP, Las Vegas

89121

Cancer Therapy and Integrative Medicine, Las Vegas

89128

Cancer and Blood Specialists-Tenaya, Las Vegas

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas

Oncology Las Vegas - Tenaya, Las Vegas

89144

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas

89148

Comprehensive Cancer Centers of Nevada, Las Vegas

GenesisCare USA - Fort Apache, Las Vegas

OptumCare Cancer Care at Fort Apache, Las Vegas

89149

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas

89169

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

92270

Eisenhower Medical Center, Rancho Mirage

93940

Community Hospital of Monterey Peninsula, Monterey

94304

Stanford Cancer Institute Palo Alto, Palo Alto

VA Palo Alto Health Care System, Palo Alto

95355

Memorial Medical Center, Modesto

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06050

The Hospital of Central Connecticut, New Britain

46514-2098

Elkhart Clinic, Elkhart

03909

York Hospital, York Village

89148-2405

Las Vegas Cancer Center-Medical Center, Las Vegas

08103

Cooper Hospital University Medical Center, Camden

07018-1095

Veterans Adminstration New Jersey Health Care System, East Orange

07601

Hackensack University Medical Center, Hackensack

07740

Monmouth Medical Center, Long Branch

07960

Morristown Medical Center, Morristown

08060

Virtua Memorial, Mount Holly

07101

Rutgers New Jersey Medical School, Newark

07902

Overlook Hospital, Summit

08360

Inspira Medical Center Vineland, Vineland

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54301-3526

Green Bay Oncology at Saint Vincent Hospital, Green Bay

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT01708954 - Erlotinib Hydrochloride and Cabozantinib-s-Malate Alone or in Combination as Second or Third Line Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer | Biotech Hunter | Biotech Hunter