125
Participants
Start Date
February 13, 2013
Primary Completion Date
August 14, 2015
Study Completion Date
March 18, 2026
Cabozantinib S-malate
Given PO
Erlotinib Hydrochloride
Given PO
Laboratory Biomarker Analysis
Correlative studies
Montefiore Medical Center-Weiler Hospital, The Bronx
Montefiore Medical Center - Moses Campus, The Bronx
Dickstein Cancer Treatment Center, White Plains
Stony Brook University Medical Center, Stony Brook
UPMC Hillman Cancer Center Erie, Erie
Geisinger Medical Group, State College
WellSpan Health-York Hospital, York
Lancaster General Hospital, Lancaster
Geisinger Medical Center, Danville
Geisinger Medical Oncology-Lewisburg, Lewisburg
Geisinger Cancer Services-Pottsville, Pottsville
Geisinger Medical Center-Cancer Center Hazleton, Hazleton
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre
Guthrie Medical Group PC-Robert Packer Hospital, Sayre
Doylestown Hospital, Doylestown
Bryn Mawr Hospital, Bryn Mawr
Lankenau Medical Center, Wynnewood
Main Line Health NCORP, Wynnewood
Thomas Jefferson University Hospital, Philadelphia
Einstein Medical Center Philadelphia, Philadelphia
Paoli Memorial Hospital, Paoli
Delaware Clinical and Laboratory Physicians PA, Newark
Helen F Graham Cancer Center, Newark
Medical Oncology Hematology Consultants PA, Newark
Christiana Care Health System-Christiana Hospital, Newark
Christiana Care Health System-Wilmington Hospital, Wilmington
Beebe Medical Center, Lewes
Beebe Health Campus, Rehoboth Beach
TidalHealth Nanticoke / Allen Cancer Center, Seaford
Greater Baltimore Medical Center, Baltimore
Christiana Care - Union Hospital, Elkton
Fredericksburg Oncology Inc, Fredericksburg
West Virginia University Charleston Division, Charleston
Wheeling Hospital/Schiffler Cancer Center, Wheeling
West Virginia University Healthcare, Morgantown
Atlanta VA Medical Center, Decatur
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Atrium Health Navicent, Macon
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
Delaware Health Center-Grady Cancer Center, Delaware
Delaware Radiation Oncology, Delaware
Grady Memorial Hospital, Delaware
Knox Community Hospital, Mount Vernon
Licking Memorial Hospital, Newark
Newark Radiation Oncology, Newark
Saint Ann's Hospital, Westerville
Fairfield Medical Center, Lancaster
Columbus Oncology and Hematology Associates Inc, Columbus
Riverside Methodist Hospital, Columbus
Columbus NCI Community Oncology Research Program, Columbus
Grant Medical Center, Columbus
The Mark H Zangmeister Center, Columbus
Mount Carmel Health Center West, Columbus
Doctors Hospital, Columbus
Toledo Clinic Cancer Centers-Bowling Green, Bowling Green
Toledo Clinic Cancer Centers-Maumee, Maumee
ProMedica Flower Hospital, Sylvania
Fulton County Health Center, Wauseon
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
Mercy Health - Saint Vincent Hospital, Toledo
University of Toledo, Toledo
Saint Charles Hospital, Oregon
Toledo Clinic Cancer Centers-Oregon, Oregon
Toledo Community Hospital Oncology Program CCOP, Toledo
Mercy Health - Saint Anne Hospital, Toledo
Toledo Clinic Cancer Centers-Toledo, Toledo
Genesis Healthcare System Cancer Care Center, Zanesville
Case Western Reserve University, Cleveland
MetroHealth Medical Center, Cleveland
Summa Health System - Akron Campus, Akron
Cleveland Clinic Mercy Hospital, Canton
Mercy Hospital of Tiffin, Tiffin
Springfield Regional Medical Center, Springfield
Adena Regional Medical Center, Chillicothe
Southern Ohio Medical Center, Portsmouth
Strecker Cancer Center-Belpre, Belpre
Marietta Memorial Hospital, Marietta
Saint Rita's Medical Center, Lima
Lima Memorial Hospital, Lima
Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
IU Health Central Indiana Cancer Centers-East, Indianapolis
IU Health La Porte Hospital, La Porte
Franciscan Saint Anthony Health-Michigan City, Michigan City
Woodland Cancer Care Center, Michigan City
Michiana Hematology Oncology PC-Westville, Westville
Michiana Hematology Oncology PC-Elkhart, Elkhart
Elkhart General Hospital, Elkhart
Michiana Hematology Oncology PC-Mishawaka, Mishawaka
Saint Joseph Regional Medical Center-Mishawaka, Mishawaka
Michiana Hematology Oncology PC-Plymouth, Plymouth
Memorial Hospital of South Bend, South Bend
South Bend Clinic, South Bend
Northern Indiana Cancer Research Consortium, South Bend
Community Howard Regional Health, Kokomo
IU Health Ball Memorial Hospital, Muncie
IU Health Bloomington, Bloomington
Lake Huron Medical Center, Port Huron
Henry Ford Health Warren Hospital, Warren
Michigan Cancer Research Consortium NCORP, Ann Arbor
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
Corewell Health Dearborn Hospital, Dearborn
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Mercy Memorial Hospital, Monroe
Toledo Clinic Cancer Centers-Monroe, Monroe
Henry Ford Health Saint John Hospital, Detroit
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
Genesys Hurley Cancer Institute, Flint
Hurley Medical Center, Flint
MyMichigan Medical Center Saginaw, Saginaw
University of Michigan Health - Sparrow Lansing, Lansing
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
Beacon Kalamazoo, Kalamazoo
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
Allegiance Health, Jackson
Bixby Medical Center, Adrian
Hickman Cancer Center, Adrian
OSF Saint Francis Hospital and Medical Group, Escanaba
Mary Greeley Medical Center, Ames
McFarland Clinic - Ames, Ames
McFarland Clinic - Boone, Boone
McFarland Clinic - Jefferson, Jefferson
McFarland Clinic - Marshalltown, Marshalltown
Mercy Medical Center-West Lakes, West Des Moines
Iowa Methodist Medical Center, Des Moines
Iowa-Wide Oncology Research Coalition NCORP, Des Moines
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
Mercy Medical Center - Des Moines, Des Moines
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
Iowa Lutheran Hospital, Des Moines
Mercy Cancer Center-West Lakes, Clive
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
Mercy Medical Center - North Iowa, Mason City
Siouxland Regional Cancer Center, Sioux City
Mercy Medical Center-Sioux City, Sioux City
Saint Luke's Regional Medical Center, Sioux City
Mercy Hospital, Cedar Rapids
Oncology Associates at Mercy Medical Center, Cedar Rapids
Constantinou, Costas L MD (UIA Investigator), Bettendorf
University of Wisconsin Carbone Cancer Center - Johnson Creek, Johnson Creek
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
HSHS Saint Nicholas Hospital, Sheboygan
ProHealth Waukesha Memorial Hospital, Waukesha
Medical College of Wisconsin, Milwaukee
SSM Health Dean Medical Group - South Madison Campus, Madison
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Cancer Center of Western Wisconsin, New Richmond
Bay Area Medical Center, Marinette
Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls
Holy Family Memorial Hospital, Manitowoc
Saint Vincent Hospital Cancer Center Green Bay, Green Bay
Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay
Marshfield Clinic-Wausau Center, Wausau
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center, Marshfield
Marshfield Medical Center - Weston, Weston
Aspirus Cancer Care - Stevens Point, Stevens Point
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander
Saint Mary's Hospital, Rhinelander
Marshfield Medical Center - Minocqua, Minocqua
HSHS Sacred Heart Hospital, Eau Claire
Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire
Marshfield Clinic-Chippewa Center, Chippewa Falls
Marshfield Medical Center-Rice Lake, Rice Lake
Lakeview Hospital, Stillwater
Regions Hospital, Saint Paul
United Hospital, Saint Paul
Minnesota Oncology Hematology PA-Maplewood, Maplewood
Saint John's Hospital - Healtheast, Maplewood
Minnesota Oncology Hematology PA-Woodbury, Woodbury
Fairview Ridges Hospital, Burnsville
Hutchinson Area Health Care, Hutchinson
Saint Francis Regional Medical Center, Shakopee
Ridgeview Medical Center, Waconia
Abbott-Northwestern Hospital, Minneapolis
Hennepin County Medical Center, Minneapolis
Metro Minnesota Community Oncology Research Consortium, Saint Louis Park
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
North Memorial Medical Health Center, Robbinsdale
Unity Hospital, Fridley
Mercy Hospital, Coon Rapids
Fairview Southdale Hospital, Edina
New Ulm Medical Center, New Ulm
Rice Memorial Hospital, Willmar
Sanford Joe Lueken Cancer Center, Bemidji
Sanford Cancer Center Oncology Clinic, Sioux Falls
Sanford Broadway Medical Center, Fargo
Sanford Roger Maris Cancer Center, Fargo
NorthShore University HealthSystem-Glenbrook Hospital, Glenview
Hematology Oncology Associates of Illinois-Highland Park, Highland Park
NorthShore University HealthSystem-Highland Park Hospital, Highland Park
AMG Libertyville - Oncology, Libertyville
Hematology Oncology Associates of Illinois - Skokie, Skokie
NorthShore University HealthSystem-Evanston Hospital, Evanston
Ingalls Memorial Hospital, Harvey
Rush-Copley Medical Center, Aurora
Rush-Copley Healthcare Center, Yorkville
Northwestern University, Chicago
Illinois Cancer Specialists-Niles, Niles
Presence Saint Mary's Hospital, Kankakee
Swedish American Hospital, Rockford
UW Health Carbone Cancer Center Rockford, Rockford
Garneau, Stewart C MD (UIA Investigator), Moline
Porubcin, Michael MD (UIA Investigator), Moline
Spector, David MD (UIA Investigator), Moline
Trinity Medical Center, Moline
Illinois CancerCare-Ottawa Clinic, Ottawa
Ottawa Regional Hospital and Healthcare Center, Ottawa
Illinois CancerCare-Peru, Peru
Illinois Valley Hospital, Peru
Illinois CancerCare-Princeton, Princeton
Illinois CancerCare-Galesburg, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Illinois CancerCare-Monmouth, Monmouth
Illinois CancerCare-Canton, Canton
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Pekin, Pekin
OSF Saint Francis Radiation Oncology at Pekin, Pekin
Proctor Hospital, Peoria
Illinois CancerCare-Peoria, Peoria
Methodist Medical Center of Illinois, Peoria
OSF Saint Francis Medical Center, Peoria
OSF Saint Joseph Medical Center, Bloomington
Illinois CancerCare-Bloomington, Bloomington
Carle Cancer Institute Normal, Normal
Carle Cancer Center, Urbana
The Carle Foundation Hospital, Urbana
Carle at The Riverfront, Danville
Carle Physician Group-Mattoon/Charleston, Mattoon
Illinois CancerCare-Carthage, Carthage
Carle Physician Group-Effingham, Effingham
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Heartland Cancer Research NCORP, Decatur
Springfield Memorial Hospital, Springfield
Centralia Oncology Clinic, Centralia
Saint Francis Medical Center, Cape Girardeau
Lawrence Memorial Hospital, Lawrence
Cancer Center of Kansas-Manhattan, Manhattan
Cancer Center of Kansas - Fort Scott, Fort Scott
Cancer Center of Kansas - Chanute, Chanute
Cancer Center of Kansas - El Dorado, El Dorado
Cancer Center of Kansas-Kingman, Kingman
Cancer Center of Kansas - Newton, Newton
Cancer Center of Kansas - Pratt, Pratt
Cancer Center of Kansas - Wellington, Wellington
Cancer Center of Kansas - Winfield, Winfield
Associates In Womens Health, Wichita
Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita
Ascension Via Christi Hospitals Wichita, Wichita
Cancer Center of Kansas - Wichita, Wichita
Wichita NCI Community Oncology Research Program, Wichita
Cancer Center of Kansas-Independence, Independence
Cancer Center of Kansas - Parsons, Parsons
Cancer Center of Kansas - Salina, Salina
Cancer Center of Kansas - McPherson, McPherson
Cancer Center of Kansas - Dodge City, Dodge City
Cancer Center of Kansas-Liberal, Liberal
Missouri Valley Cancer Consortium, Omaha
Alegent Health Immanuel Medical Center, Omaha
Alegent Health Bergan Mercy Medical Center, Omaha
Alegent Health Lakeside Hospital, Omaha
Creighton University Medical Center, Omaha
Nebraska Cancer Research Center, Lincoln
Ochsner Baptist Medical Center, New Orleans
Ochsner Medical Center Jefferson, New Orleans
Ochsner Health Center-Summa, Baton Rouge
University of Texas Health Science Center at Tyler, Tyler
Cancer Therapy and Research Center at The UT Health Science Center at San Antonio, San Antonio
University of Texas Health Science Center at San Antonio, San Antonio
Dell Seton Medical Center at The University of Texas, Austin
The Medical Center of Aurora, Aurora
Rocky Mountain Cancer Centers-Greenwood Village, Greenwood Village
Mountain Blue Cancer Care Center - Swedish, Englewood
Swedish Medical Center, Englewood
AdventHealth Littleton, Littleton
Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree
Sky Ridge Medical Center, Lone Tree
AdventHealth Parker, Parker
Rocky Mountain Cancer Centers-Parker, Parker
AdventHealth Porter, Denver
Colorado Blood Cancer Institute, Denver
Presbyterian - Saint Lukes Medical Center - Health One, Denver
Rocky Mountain Cancer Centers-Midtown, Denver
Saint Joseph Hospital - Cancer Centers of Colorado, Denver
Rocky Mountain Cancer Centers-Rose, Denver
Rose Medical Center, Denver
Western States Cancer Research NCORP, Denver
Rocky Mountain Cancer Centers-Lakewood, Lakewood
Saint Anthony Hospital, Lakewood
Boulder Community Foothills Hospital, Boulder
Rocky Mountain Cancer Centers-Boulder, Boulder
Mountain Blue Cancer Care Center, Golden
Intermountain Health Lutheran Hospital, Wheat Ridge
Longmont United Hospital, Longmont
Rocky Mountain Cancer Centers-Longmont, Longmont
Banner McKee Medical Center, Loveland
Banner North Colorado Medical Center, Greeley
Penrose-Saint Francis Healthcare, Colorado Springs
Rocky Mountain Cancer Centers-Penrose, Colorado Springs
Saint Mary Corwin Medical Center, Pueblo
Rocky Mountain Cancer Centers - Pueblo, Pueblo
Mercy Medical Center, Durango
Saint Alphonsus Cancer Care Center-Boise, Boise
Mayo Clinic in Arizona, Scottsdale
University of New Mexico Cancer Center, Albuquerque
Memorial Medical Center-Las Cruces, Las Cruces
Cancer and Blood Specialists-Henderson, Henderson
Comprehensive Cancer Centers of Nevada - Henderson, Henderson
Las Vegas Cancer Center-Henderson, Henderson
Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson
Oncology Las Vegas - Henderson, Henderson
University Medical Center of Southern Nevada, Las Vegas
Cancer and Blood Specialists-Shadow, Las Vegas
Radiation Oncology Centers of Nevada Central, Las Vegas
GenesisCare USA - Las Vegas, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas
Radiation Oncology Centers of Nevada Southeast, Las Vegas
Nevada Cancer Research Foundation NCORP, Las Vegas
Cancer Therapy and Integrative Medicine, Las Vegas
Cancer and Blood Specialists-Tenaya, Las Vegas
Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas
Oncology Las Vegas - Tenaya, Las Vegas
Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas
Comprehensive Cancer Centers of Nevada, Las Vegas
GenesisCare USA - Fort Apache, Las Vegas
OptumCare Cancer Care at Fort Apache, Las Vegas
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas
Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas
Eisenhower Medical Center, Rancho Mirage
Community Hospital of Monterey Peninsula, Monterey
Stanford Cancer Institute Palo Alto, Palo Alto
VA Palo Alto Health Care System, Palo Alto
Memorial Medical Center, Modesto
Smilow Cancer Hospital Care Center at Saint Francis, Hartford
The Hospital of Central Connecticut, New Britain
Elkhart Clinic, Elkhart
York Hospital, York Village
Las Vegas Cancer Center-Medical Center, Las Vegas
Cooper Hospital University Medical Center, Camden
Veterans Adminstration New Jersey Health Care System, East Orange
Hackensack University Medical Center, Hackensack
Monmouth Medical Center, Long Branch
Morristown Medical Center, Morristown
Virtua Memorial, Mount Holly
Rutgers New Jersey Medical School, Newark
Overlook Hospital, Summit
Inspira Medical Center Vineland, Vineland
Penn State Milton S Hershey Medical Center, Hershey
Sanford USD Medical Center - Sioux Falls, Sioux Falls
Green Bay Oncology at Saint Vincent Hospital, Green Bay
National Cancer Institute (NCI)
NIH