3,300
Participants
Start Date
February 28, 2002
Primary Completion Date
September 30, 2021
Study Completion Date
September 30, 2026
Vincristine
given during Rapid COJEC and modified N7 therapy
Aldesleukin
Aldesleukin is given during MRD Treatment for patients randomised to the arm with IL-2
ch14.18/CHO
ch14.18/CHO antibody is given during MRD treatment
Carboplatin
Carboplatin is given during induction Treatment (R3 randomisation: Rapid COJEC arm)
Etoposide
Etoposide is given during Induction Treatment (both R3 randomisation arms)
Cisplatin
Cisplatin is given during Induction Treatment (both R3 randomisation arms)
Cyclophosphamide
Cyclophosphamid is given during Induction Treatment (both R3 randomisation arms)
Doxorubicin
Doxorubicin is given during Induction Treatment (R3 arm modified N7)
G-CSF
G-CSF is given during Induction Treatment
Busulfan
In case i.v. busulfan is not available, the use of oral busulfan is permitted, although not recommended.
Melphalan
Melphalan is given during MAT treatment
RECRUITING
St. Anna Kinderspital, Vienna
RECRUITING
University Children's Hospital Ljubljana, Ljubljana
RECRUITING
Women and Children´s Hospital, Adelaide
RECRUITING
Lady Cilento Children´s Hospital, Brisbane
RECRUITING
John Hunter Children's Hospital, Newcastle
RECRUITING
Royal Children's Hospital Melbourne, Parkville
RECRUITING
Sydney Children's Hospital, Sydney
RECRUITING
Children´s Hospital Westmead, Westmead
RECRUITING
Univ.-Klinik für Kinder- und Jugendheilkunde Graz, Graz
RECRUITING
Univ.Klinik f. Kinder-u. Jugendheilkunde Innsbruck, Innsbruck
RECRUITING
Landes- Kinderklinik Linz, Linz
RECRUITING
St. Johanns Spital LKH Salzburg, Salzburg
RECRUITING
Cliniques universitaires St-Luc, Brussels
RECRUITING
Hôpital des Enfants, Brussels
RECRUITING
University Hospital Gent, Ghent
RECRUITING
UZ Gasthuisberg, Leuven
RECRUITING
CHR Citadelle, Liège
RECRUITING
Clinique de l'Espérance, Montegnée
RECRUITING
University Hospital Motol, Prague
RECRUITING
Aarhus Universitetshospital, Aarhus
RECRUITING
National State Hospital, Copenhagen
RECRUITING
University Hospital of Odense, Odense
RECRUITING
Skejby Hospital, Skejby
RECRUITING
Hopital d'Enfants Dijon, Dijon
RECRUITING
CHU de Grenoble, Grenoble
RECRUITING
CHR Pellegrin, Le Pellerin
RECRUITING
Centre Oscar Lambret de Lille, Lille
RECRUITING
Hopitaux de Marseille La Timone, Marseille
RECRUITING
CHR de Nantes, Nantes
RECRUITING
Hôpital Trousseau Paris, Paris
RECRUITING
Institut Curie, Paris
RECRUITING
Hôpital American Memorial Hospital, Reims
RECRUITING
CHU-Saint Etienne, Saint-Etienne
RECRUITING
Hôpital de Hautepierre, Strasbourg
RECRUITING
Hôpital D'Enfants de Toulouse, Toulouse
RECRUITING
Institut Gustave Roussy, Villejuif
RECRUITING
"A&P Kyriakou Children's Hospital", Athens
RECRUITING
Aghia Sophia Children's Hospital, Athens
RECRUITING
MITERA Hospital, Heraklion
RECRUITING
PEPAGNH University Hospital, Heraklion
RECRUITING
Madarász Children Hospital Budapest, Budapest
RECRUITING
Semmelweis University of Budapest, Budapest
RECRUITING
University of Debrecen, Debrecen
RECRUITING
University of Pecs, Pécs
RECRUITING
University of Szeged, Szeged
RECRUITING
Dublin: OLHSC, Dublin
RECRUITING
Rambam Medical Centre, Haifa
RECRUITING
Schneider Children's Medical Center of Israel, Petah Tikva
RECRUITING
Sheba Medical Center, Tel Aviv
RECRUITING
Ospedale G. Salesi, Ancona
RECRUITING
Universitŕ degli studi di Bari, Bari
RECRUITING
Ospedali Riuniti, Bergamo
RECRUITING
Ospedale S. Orsola, Bologna
RECRUITING
Ospedale Regionale per le Microcitemie, Cagliari
RECRUITING
Azienda Ospedaliera di Cosenza, Cosenza
RECRUITING
Azienda Ospedaliera A. Meyer, Florence
RECRUITING
Istituto Giannina Gaslini, Genoa
RECRUITING
Istituto Nazionale Tumori di Milano, Milan
RECRUITING
Azienda Ospedal. Univ. di Modena, Modena
RECRUITING
Sec. Univ. degli Studi di Napoli - Policlinico, Napoli
RECRUITING
Clinica di Oncoematologia Pediatrica Padova, Padua
RECRUITING
Ospedale dei Bambini, Palermo, Palermo
RECRUITING
Azienda Ospedaliera Universitaria di Parma-Oncoematologia Pediatrica, Parma
RECRUITING
Policlinico San Matteo, Pavia
RECRUITING
Ospedale Civile Spirito Santo, Pescara
RECRUITING
"Ospedale Infermi ", Rimini
RECRUITING
Policlinico Borgo Roma, Roma
RECRUITING
Ospedale Bambino Gesu, Rome
RECRUITING
Casa Sollievo della Sofferenza, San Giovanni Rotondo
RECRUITING
O.I.R.M. - S. Anna, Torino
RECRUITING
"Istituto per l'Infanzia Burlo Garofolo", Trieste
RECRUITING
Haukeland University Hospital, Bergen
RECRUITING
Rikshospitalet, Oslo
RECRUITING
University Hospital of North-Norway, Tromsø
RECRUITING
Medical University of Bialystok, Bialystok
RECRUITING
Medical University of Bydgoszcz, Bydgoszcz
RECRUITING
Childrens' Hospital in Chorzów, Chorzów
RECRUITING
Medical University in Gdansk, Gdansk
RECRUITING
Upper Silesian Centre of Child and Mother's Care, Katowice
RECRUITING
University Children's Hospital, Krakow
RECRUITING
Children's University Hospital in Lublin, Lublin
RECRUITING
University of Medical Sciences Poznan, Poznan
RECRUITING
Institute Mother and Child, Warsaw
RECRUITING
Wroclaw Medical University, Wroclaw
RECRUITING
Ipofg-Crl, Lisbon
RECRUITING
University Hospital F. D. Roosevelt, Banská Bystrica
RECRUITING
H . Materno-Infantil Teresa Herrera, A Coruña
RECRUITING
H. General de Alicante, Alicante
RECRUITING
Hospital Vall d'Hebron, Barcelona
RECRUITING
Hospital de Cruces, Bilbao
RECRUITING
Complejo Hospitalario de Jaen, Jaén
RECRUITING
H. Monteprincipe, Madrid
RECRUITING
Hospital 12 de Octubre, Madrid
RECRUITING
H Central de Asturias, Oviedo
RECRUITING
H. C. U. de Salamanca, Salamanca
RECRUITING
H. de Donostia Ntra. Sra. de Aranzazu, San Sebastián
RECRUITING
H. General de Galicia, Santiago de Compostela
RECRUITING
Hospital Virgen del Rocio, Seville
RECRUITING
Carlos Haya, Valencia
RECRUITING
Hospital Infantil La Fe, Valencia
RECRUITING
H Clinico-Universitario, Zaragoza
RECRUITING
Queen Silvia's Children's Hospital, Göteburg
RECRUITING
Childrens Hospital Linkoping, Linköping
RECRUITING
University Children's Hospital, Geneva
RECRUITING
CHUV, Lausanne
RECRUITING
Aberdeen: Royal Aberdeen Children's Hospital, Aberdeen
RECRUITING
Royal Belfast Hospital for Sick Children, Belfast
RECRUITING
Birmingham Children's Hospital, Birmingham
RECRUITING
Bristol Royal Hospital for Children, Bristol
RECRUITING
Addenbrooke's NHS Trust, Cambridge
RECRUITING
Llandough Hospital, Cardiff
RECRUITING
Edinburgh Royal Hospital for Sick Children, Edinburgh
RECRUITING
Glasgow Royal Hospital for Sick Children, Glasgow
RECRUITING
Leeds: St James's University Hospital, Leeds
RECRUITING
Leicester Royal Infirmary, Leicester
RECRUITING
Liverpool: Alder Hey Children's Hospital, Liverpool
RECRUITING
Great Ormond Street Hospital, London
RECRUITING
St Bartholomew's Hospital, London
RECRUITING
UCLH University College London Hospital, London
RECRUITING
Royal Manchester Children's Hospital, Manchester
RECRUITING
Newcastle: Royal Victoria Infirmary, Newcastle
RECRUITING
Nottingham: Queen's Medical Centre, Nottingham
RECRUITING
Oxford: John Radcliffe Hospital, Oxford
RECRUITING
Sheffield Children's Hospital, Sheffield
RECRUITING
Southampton General Hospital, Southhampton
RECRUITING
Royal Marsden Hospital, Sutton
St. Anna Kinderkrebsforschung
OTHER