First-Line Treatment for Locally Advanced or Metastatic Mesenchymal Epithelial Transition Factor (MET) - Positive Gastric, Lower Esophageal, or Gastroesophageal Junction (GEJ) Adenocarcinoma

PHASE3TerminatedINTERVENTIONAL
Enrollment

609

Participants

Timeline

Start Date

October 31, 2012

Primary Completion Date

November 30, 2014

Study Completion Date

August 31, 2015

Conditions
Gastric Cancer
Interventions
DRUG

Rilotumumab

Rilotumumab is a fully human monoclonal antibody immunoglobulin G, type 2 (IgG2) against human hepatocyte growth factor/scatter factor (HGF/SF) that blocks binding of HGF/SF to its receptor MET, inhibiting HGF/MET-driven activities in cells.

OTHER

Placebo

Placebo

DRUG

Epirubicin

Epirubicin is an anthracycline cytotoxic agent.

DRUG

Cisplatin

Cisplatin is a non-cell cycle specific chemotherapeutic agent.

DRUG

Capecitabine

Capecitabine is an oral fluoropyrimidine.

Trial Locations (189)

1090

Research Site, Vienna

1097

Research Site, Budapest

1106

Research Site, Budapest

1180

Research Site, Brussels

1200

Research Site, Brussels

1233

Research Site, Sofia

1527

Research Site, Sofia

1606

Research Site, Sofia

1756

Research Site, Sofia

2031

Research Site, Randwick

2065

Research Site, St Leonards

2100

Research Site, Copenhagen

2193

Research Site, Johannesburg

2485

Research Site, Tweed Heads

2650

Research Site, Edegem

3010

Research Site, Bern

3084

Research Site, Heidelberg

3135

Research Site, Ringwood East

4000

Research Site, Liège

Research Site, Plovdiv

4010

Research Site, Linz

4400

Research Site, Nyíregyháza

4814

Research Site, Douglas

5000

Research Site, Odense

Research Site, Szolnok

5020

Research Site, Salzburg

5037

Research Site, Kurralta Park

5112

Research Site, Elizabeth Vale

6000

Research Site, Charleroi

6020

Research Site, Innsbruck

6500

Research Site, Bellinzona

6725

Research Site, Szeged

7000

Research Site, Chur

7570

Research Site, Kraaifontein

7925

Research Site, Cape Town

8000

Research Site, Århus C

8036

Research Site, Graz

8800

Research Site, Roeselare

9000

Research Site, Aalborg

9010

Research Site, Varna

9023

Research Site, Győr

9700

Research Site, Shumen

10065

Research Site, New York

13125

Research Site, Berlin

13385

Research Site, Marseille

14000

Research Site, Mexico City

14564

Research Site, Nea Kifissia, Athens

14642

Research Site, Rochester

15006

Research Site, A Coruña

15232

Research Site, Pittsburgh

18547

Research Site, Athens

21079

Research Site, Dijon

21231

Research Site, Baltimore

24004

Research Site, Périgueux

25124

Research Site, Brescia

26133

Research Site, Oldenburg

26500

Research Site, Pátrai

27100

Research Site, Gaziantep

27103

Research Site, Winston-Salem

27403

Research Site, Greensboro

28050

Research Site, Madrid

31008

Research Site, Pamplona

33011

Research Site, Oviedo

33075

Research Site, Bordeaux

33081

Research Site, Aviano PN

33611

Research Site, Bielefeld

34298

Research Site, Montpellier

34390

Research Site, Istanbul

35100

Research Site, Izmir

37232

Research Site, Nashville

39104

Research Site, Magdeburg

40022

Research Site, Sumy

41110

Research Site, Larissa

42270

Research Site, Saint-Priest-en-Jarez

43018

Research Site, Lutsk

45276

Research Site, Essen

49102

Research Site, Dnipropetrovsk

50080

Research Site, Toluca

50134

Research Site, Florence

54645

Research Site, Thessaloniki

55125

Research Site, Woodbury

55131

Research Site, Mainz

56126

Research Site, Pisa

56429

Research Site, Thessaloniki

60488

Research Site, Frankfurt am Main

60637

Research Site, Chicago

61070

Research Site, Kharkiv

62290

Research Site, Cuernavaca

63003

Research Site, Clermont-Ferrand

64109

Research Site, Bayonne

67000

Research Site, Strasbourg

69373

Research Site, Lyon

69437

Research Site, Lyon

71110

Research Site, Heraklion - Crete

72000

Research Site, Le Mans

73035

Research Site, Kherson

75246

Research Site, Dallas

76022

Research Site, Bedford

79031

Research Site, Lviv

80045

Research Site, Aurora

80131

Research Site, Napoli

81008

Research Site, Pueblo

81377

Research Site, München

81737

Research Site, München

85724

Research Site, Tucson

87042

Research Site, Limoges

87500

Research Site, Mariupol

88000

Research Site, Uzhhorod

89052

Research Site, Henderson

95122

Research Site, Catania

97422

Research Site, Schweinfurt

98109

Research Site, Seattle

115478

Research Site, Moscow

153013

Research Site, Ivanovo

197758

Research Site, Saint Petersburg

300167

Research Site, Timișoara

350040

Research Site, Krasnodar

400015

Research Site, Cluj-Napoca

400058

Research Site, Cluj-Napoca

420029

Research Site, Kazan'

430241

Research Site, Baia Mare

443031

Research Site, Samara

454087

Research Site, Chelyabinsk

500091

Research Site, Brasov

510077

Research Site, Alba Iulia

600020

Research Site, Vladimir

700106

Research Site, Lasi

30150-321

Research Site, Belo Horizonte

96015-280

Research Site, Pelotas

09060-650

Research Site, Santo André

01209-000

Research Site, São Paulo

01246-000

Research Site, São Paulo

01509-900

Research Site, São Paulo

V5Z 4E6

Research Site, Vancouver

N6A 4L6

Research Site, London

M4C 3E7

Research Site, Toronto

J4V 2H1

Research Site, Greenfield Park

H7M 3L9

Research Site, Laval

H2L 4M1

Research Site, Montreal

268 31

Research Site, Hořovice

500 05

Research Site, Hradec Králové

775 20

Research Site, Olomouc

120 00

Research Site, Prague

401 13

Research Site, Ústí nad Labem

06189

Research Site, Nice

01307

Research Site, Dresden

04103

Research Site, Leipzig

00168

Research Site, Roma

04380

Research Site, Distrito Federal

15-027

Research Site, Bialystok

82-300

Research Site, Elblag

80-219

Research Site, Gdansk

62-500

Research Site, Konin

93-513

Research Site, Lodz

02-781

Research Site, Warsaw

3814-501

Research Site, Aveiro

4835-044

Research Site, Guimarães

1649-035

Research Site, Lisbon

4200-072

Research Site, Porto

4520-211

Research Site, Santa Maria da Feira

5000-508

Research Site, Vila Real

010719

Research Site, Bucharest

011461

Research Site, Bucharest

022328

Research Site, Bucharest

085 01

Research Site, Bardejov

833 10

Research Site, Bratislava

058 01

Research Site, Poprad

911 71

Research Site, Trenčín

0181

Research Site, Groenkloof

0002

Research Site, Pretoria

08035

Research Site, Barcelona

08907

Research Site, L'Hospitalet de Llobregat

08221

Research Site, Terrassa

631 88

Research Site, Eskilstuna

171 76

Research Site, Stockholm

06100

Research Site, Ankara

03115

Research Site, Kyiv

BT9 7AB

Research Site, Belfast

EH4 2XU

Research Site, Edinburgh

GU2 7XX

Research Site, Guildford

LE1 5WW

Research Site, Leicester

NW1 2PQ

Research Site, London

SE1 9RT

Research Site, London

SW3 6JJ

Research Site, London

M20 4BX

Research Site, Manchester

NE7 7DN

Research Site, Newcastle upon Tyne

HA6 2RN

Research Site, Northwood

SP2 8BJ

Research Site, Salisbury

SM2 5PT

Research Site, Sutton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY