A Study of Vanucizumab (RO5520985) Alone or in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

132

Participants

Timeline

Start Date

October 31, 2012

Primary Completion Date

December 2, 2016

Study Completion Date

March 12, 2018

Conditions
Neoplasms
Interventions
BIOLOGICAL

Atezolizumab [TECENTRIQ]

Participants will receive atezolizumab at a fixed dose of 840 mg, intravenously every 2 weeks.

BIOLOGICAL

Vanucizumab

Participants will receive escalating doses of vanucizumab (starting dose: 3 milligram \[mg\] per kilogram) and fixed dose of vanucizumab (MTD/RP2D: 30 mg/kg), intravenously every 2 weeks.

Trial Locations (14)

1200

Cliniques Universitaires St-Luc, Brussels

3000

UZ Leuven Gasthuisberg, Leuven

14076

Centre Francois Baclesse; Oncologie, Caen

28041

Hospital Universitario 12 de Octubre; Servicio de Oncologia, Madrid

28050

Centro Integral Oncologico Clara Campal (CIOCC); Dirección Médica, Madrid

31008

Clinica Universitaria de Navarra; Servicio de Oncologia, Pamplona

33076

Institut Bergonie; Oncologie, Bordeaux

44805

ICO - Site René Gauducheau, Saint-Herblain

46010

Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia

69373

Centre Leon Berard; Departement Oncologie Medicale, Lyon

75231

Institut Curie; Oncologie Medicale, Paris

94805

Institut Gustave Roussy; Sitep, Villejuif

08003

Hospital del Mar; Servicio de Oncologia, Barcelona

08035

Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT01688206 - A Study of Vanucizumab (RO5520985) Alone or in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors | Biotech Hunter | Biotech Hunter