49
Participants
Start Date
September 30, 2012
Primary Completion Date
July 31, 2014
Study Completion Date
December 31, 2014
AT13387
Regimen 1: AT13387, given as 1-hr intravenous infusion at starting dose of 220 mg/m2 once weekly for 3 weeks in a 4-week cycle. Regimen 2: AT13387, given as 1-hr IV infusion at starting dose of 120 mg/m2 on Day 1 and Day 2 weekly for 3 weeks in a 4-week cycle.
abiraterone acetate
1000 mg PO daily.
Prednisone
5 mg PO twice daily.
Columbia University Medical Center, New York
Memorial Sloan Kettering Cancer Center, New York
Clinical Research Alliance, Inc., Lake Success
SUNY Upstate Medical University, Syracuse
Roswell Park Cancer Institute, Buffalo
University of Pittsburgh Medical Center, Pittsburgh
Center for Cancer & Blood Disorders, Bethesda
University of Maryland, Greenebaum Cancer Center, Baltimore
Centro Integral Oncologico Clara Campal, Madrid
Holy Cross Hospital, Fort Lauderdale
Lakeland Regional Cancer Center, Lakeland
Florida Cancer Specialists-Fort Myers, Fort Myers
The West Clinic, Memphis
Cleveland Clinic, Cleveland
Southern Illinois University School of Medicine, Springfield
Washington University School of Medicine, St Louis
University of Nebraska Medical Center, Omaha
Comprehensive Cancer Centers of Nevada, Las Vegas
University of California, Los Angeles Institute of Urologic Oncology, Los Angeles
Stanford Cancer Center, Stanford
Northwest Medical Specialists, PLLC, Tacoma
Centre hospitalier de l'Universite de Montreal (CHUM), Montreal
Brighton & Sussex University Hospitals NHS Trust, Brighton
Cambridge University Hospitals NHS Foundation Trust, Cambridge
Velindre Cancer Center, Cardiff
University of Surrey, Guildford
Charing Cross Hospital, London
Royal Marsden Foundation Trust Instute of Cancer Researrch, London
The Christie Hospital NHS Trust, Manchester
Clatterbridge Cancer Centre NHS Foundation Trust, Metropolitan Borough of Wirral
Nottingham University Hospitals, Nottingham
University Hospital Southampton, Southampton
Lead Sponsor
Astex Pharmaceuticals, Inc.
INDUSTRY