Study of Tcelna (Imilecleucel-T) in Secondary Progressive Multiple Sclerosis

PHASE2CompletedINTERVENTIONAL
Enrollment

183

Participants

Timeline

Start Date

August 31, 2012

Primary Completion Date

October 31, 2016

Study Completion Date

October 31, 2016

Conditions
Autoimmune Diseases of the Nervous SystemMultiple SclerosisSecondary Progressive Multiple SclerosisDisease ProgressionBrain Atrophy
Interventions
BIOLOGICAL

Tcelna

Autologous pool of myelin reactive T-cells (MRTC) expanded ex vivo with immunodominant epitopes selected from the three myelin antigens, MBP, PLP and MOG on a per subject basis. Attenuated by irradiation to prevent further proliferation before releasing product for administration.

BIOLOGICAL

Placebo

2 ml of Tcelna excipients, prepared daily as individual doses and irradiated before releasing product for administration.

Trial Locations (36)

11803

Island Neurological Assoicates, PC, Plainview

19104

University of Pennsylvania, Philadelphia

23226

Neurological Associates, Inc, Richmond

23601

Hampton Roads Neurology, Newport News

28204

The Neurological Institute, PA, Charlotte

28207

Carolinas Medical Center Neurology, Charlotte

28209

PMG Research of Charlotte, Charlotte

30309

Shepherd Center, Atlanta

32751

Neurology Associates, P.A., Maitland

32806

Neurological Services of Orlando, Orlando

32960

Vero Beach Neurology, Vero Beach

33136

University of Miami, Miami

33606

Meridien Research, Tampa

34102

Collier Neurologic Specialists, LLC, Naples

40503

Associates in Neurology, Lexington

45408

Neurology Specialists, Inc, Dayton

46256

Josephson Wallack Munshower Neurology, PC, Indianapolis

46804

Fort Wayne Neurological Center, Fort Wayne

60062

Consultants In Neurology, Ltd., Northbrook

66160

University of Kansas Medical Center, Kansas City

77030

The Maxine Mesinger MS Clinic/Baylor College of Medicine, Houston

78229

Integra Clinical Research, LLC, San Antonio

78681

Central Texas Neurology, Round Rock

85050

HOPE Research Institute, Phoenix

85741

Northwest NeuroSpecialists, LLC, Tucson

94705

Alta Bates Summit Medical Center, The Research and Education Development Institute, Berkeley

97225

Providence St. Vincent Medical Center - Northwest MS Center, Portland

97504

Providence Medical Group - Medford, Medford

98029

Swedish Neuroscience Institute, Issaquah

98122

Swedish Neuroscience Institute, Seattle

02135

Saint Elizabeth's Medical Center, Boston

11794-8121

University Hospital and Medical Center Stony Brook New York, Stony Brook

05401

Fletcher Allen Health Care - Neurology Service, Burlington

K1H 8L6

University of Ottawa, Ottawa

J4V 2J2

Recherche Sepmus Inc., Greenfield Park

H3A 2B4

Montreal Neurological Institute and Hospital, Montreal

Sponsors
All Listed Sponsors
lead

Opexa Therapeutics, Inc.

INDUSTRY