Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

297

Participants

Timeline

Start Date

September 30, 2012

Primary Completion Date

December 31, 2013

Study Completion Date

December 31, 2013

Conditions
Postoperative Pain
Interventions
DRUG

Placebo

Normal saline 20 mL as single-injection femoral nerve block prior to total knee arthroplasty

DRUG

EXPAREL 67 mg

5 mL EXPAREL expanded with 15 mL normal saline as single-injection femoral nerve block prior to total knee arthroplasty

DRUG

EXPAREL 133 mg

10 mL EXPAREL expanded with 10 mL normal saline as single-injection femoral nerve block prior to total knee arthroplasty

DRUG

EXPAREL 266 mg

20 mL EXPAREL as single-injection femoral nerve block prior to total knee arthroplasty

Trial Locations (30)

10025

ST. LUKE-ROOSEVELT HOSPITAL CENTER Dept. Of Anesthesiology 1111 Amsterdam Ave. Travis Bld. 7, New York

10065

INSALL-SCOTT-KELLY INSTITUTE 210 East 64th Street, New York

10549

NORTHERN WESTCHESTER HOSPTIAL Department Of Clinical Trials 400 East Main St., Mount Kisco

15232

UPMC PRESBYTERIAN SHADYSIDE/ DEPT. OF ANESTHESIOLOGY POSNER PAIN CENTER 532 South Aiken Avenue Suite 407, Pittsburgh

17033

PENN STATE MILTON S. HERSHEY MEDICAL CENTER H187,500 University Drive, Hershey

19107

THOMAS JEFFERSON UNIVERSITY Dept. Of Anesthesiology 111 S. 11th Street Suite G 8490, Philadelphia

27599

UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Department Of Anesthesiology 101 Manning Drive N0021, Cb 7010, Chapel Hill

32504

PENSACOLA RESEARCH CONSULTANTS,INC 5149 N.9th Avenue Suite 241, Pensacola

32720

FLORIDA RESEARCH ASSOCIATES, LLC / FLORIDA ORTHOPAEDIC ASSOCIATES 740 W. Plymouth Ave, DeLand

33136

JACKSON MEMORIAL HOSPITAL UNVERSITY OF MIAMI 1611 Nw. 12th Ave C300, Miami

33321

PHOENIX CLINICAL RESEARCH,LLC 7171 N. University Drive Suite 100, Tamarac

33323

SHERIDAN CLINICAL RESEARCH, INC. 1613 N. Harrison Parkway Building C Suite 200, Sunrise

35216

ACHIEVE CLINICAL RESEARCH LLC 2017 Canyon Road Suite 41, Birmingham

35660

SHOALS MEDICAL TRIALS INC. 1300 S Montgomery Ave, Sheffield

36608

HORIZON RESEARCH GROUP INC 3610 Springhill Memorial Dr. N, Mobile

36660

Veritas Research, LLC, Mobile

44111

CLEVELAND CLINIC FAIRVIEW HOSPTIAL 1801 Lorain Avenue, Cleveland

44195

CLEVELAND CLINIC 9500 Euclid Ave P-77, Cleveland

48085

BEAUMONT HEALTH SYSTEM 44201 Dequindre Road Suite Pob 120, Troy

66160

UNIVERSITY OF KANSAS HOSPITAL & MEDICAL CENTER Dept. Of Anesthesiology 3901 Rainbow Blvd. Ms 1034, Kansas City

77024

RESEARCH CONCEPTS,GP LLC 921 Gessner Rd. Anesthesia Dept., Classroom F, Houston

77058

CHRISTUS ST. JOHN HOSPITAL 18300 St. John Dr., 2nd Floor, Surgery, Nassau Bay

77551

UNIVERSITY OF TEXAS MEDICAL BRANCH Dept. Chairman, Orthopedic Surgery & Rehabilitation 2.316 Rebecca Sealy Hospital 301 University Blvd., Galveston

85023

PHOENIX ORTHOPAEDIC SURGEONS 2525 W. Greenway Road Suite 114, Phoenix

92103

University of California, San Diego, San Diego

92130

Ilfeld, Brian (Thornton) UNIVERSITY OF CALIFORNIA, SAN DIEGO 10610 Hunters Glen Drive, San Diego

92508

ORTHOPADIC SURGERY Loma Linda University Health Care Dept. Pf Orthopaedic Surgery 250 East Caroline Street Suite A, San Bernardino

92653

ALLIANCE RESEARCH CENTERS 24411 Health Center Drive Suite 350, Laguna Hills

08103

COOPER UNIVERSITY HOSPITAL 1 Cooper Plaza 202 Dorrance Building, Camden

07101

UNIVERSITY OF MEDICINE AND DENSITRY OF NEW JERSEY/NEW JERSEY MEDICAL SCHOOL 185 South Orange Ave. Department of Anesthesiology - MSB E538, Newark

Sponsors
All Listed Sponsors
lead

Pacira Pharmaceuticals, Inc

INDUSTRY

NCT01683071 - Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty | Biotech Hunter | Biotech Hunter