129
Participants
Start Date
October 31, 2013
Primary Completion Date
March 31, 2019
Study Completion Date
March 31, 2022
Cyclophosphamide
Cyclophosphamide 750mg/m2 IV, given day 1
Vincristine
Vincristine 1.4mg/m2(max 2mg)IV given day 1
Prednisolone
Prednisolone 100mg OD Oral given days 1-5
Rituximab
Rituximab 375mg/m2 IV given day 1
Inotuzumab Ozogamicin
Inotuzumab Ozogamicin 0.8mg/m2 IV given on day 2
Gemcitabine
Gemcitabine up to 1g/m2 IV given day 1 and day 8 (Patients with ECOG PS 0-1: starting dose: 875mg/m2 (1st cycle). If tolerated can be escalated to 1g/m2 in cycle 2 and subsequent cycles. Patients with ECOG PS 2: starting dose 750mg/m2 (1st cycle). If tolerated can be escalated to 875mg/m2 in cycle 2 and then escalated to 1g/m2 in cycle 3 and subsequent cycles.)
Stoke Mandeville Hospital (including Wycombe Hospital), Aylesbury
North Hampshire Hospital, Basingstoke
Royal United Hospital, Bath
Royal Bournemouth Hospital, Bournemouth
Bristol Oncology Centre, Bristol
West Suffolk Hospital, Bury St Edmunds
Kent and Canterbury Hospital, Canterbury
Castle Hill Hospital, Cottingham
University Hospital, Coventry, Coventry
Darent Valley Hospital, Dartford
Royal Devon & Exeter Hospital, Exeter
Medway Maritime Hospital, Gillingham
Beatson West of Scotland Cancer Centre (including Gartnavel Royal Hospital), Glasgow
James Paget University Hospital, Great Yarmouth
Northwick Park Hospital, Harrow
Kettering General Hospital, Kettering
St James's University Hospital, Leeds
Leicester Royal Infirmary, Leicester
Aintree University Hospital, Liverpool
Royal Liverpool University Hospital, Liverpool
Guy's Hospital (including St Thomas's Hospital), London
Royal Free Hospital, London
University College London Hospital, London
Luton and Dunstable Hospital, Luton
Christie Hospital, Manchester
Freeman Hospital, Newcastle
North Tyneside Hosptial (including Wansbeck Hospital and Hexham General Hospital), North Shields
Norfolk and Norwich University Hospital, Norwich
Nottingham City Hospital, Nottingham
Princess Royal University Hospital, Orpington
Churchill Hospital, Oxford
Derriford Hospital, Plymouth
Queen's Hospital, Romford
Southampton General Hospital, Southampton
Kings Mill Hospital, Sutton in Ashfield
Torbay Hospital, Torquay
Royal Cornwall Hospital, Truro
Royal Hampshire County Hospital, Winchester
Worcester Royal Hospital (including Kidderminster Hospital and Alexandra Hospital), Worcester
Wythenshawe Hospital (including Trafford General Hospital), Wythenshawe
Collaborators (2)
Pfizer
INDUSTRY
Cancer Research UK
OTHER
University College, London
OTHER