Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

289

Participants

Timeline

Start Date

November 30, 2012

Primary Completion Date

December 31, 2015

Study Completion Date

May 20, 2022

Conditions
Cervical CancerEndometrial CancerGastrointestinal ComplicationsPerioperative/Postoperative ComplicationsRadiation ToxicityUrinary ComplicationsUrinary Tract Toxicity
Interventions
RADIATION

Standard radiation therapy

Patients treated once a day, 5 days a week with a daily fraction size of 1.8 Gy. Whole pelvis treated with a four-field technique (AP/PA/R lateral/L lateral) to 45 or 50.4 Gy at 1.8 Gy/fraction. The dose is prescribed to the isocenter which is defined as the intersection of the four beams and can be normalized to an isodose line between 97-100%. The decision to deliver 45 or 50.4 Gy is at the physician's discretion and must be reported at the time of enrollment.

RADIATION

intensity-modulated radiation therapy

Patients treated once a day, 5 days a week with a daily fraction size of 1.8 Gy. All targets treated simultaneously. The vaginal planning target volume (PTV) (ITV with 7.0 mm margin) and nodal PTV receives 45 Gy in 25 fractions or 50.4 Gy in 28 fractions. The decision to deliver 45 or 50.4 Gy is at the physician's discretion and must be reported at the time of enrollment.

Trial Locations (137)

11040

Long Island Jewish Medical Center, New Hyde Park

North Shore-LIJ Health System/Center for Advanced Medicine, New Hyde Park

11794

Stony Brook University Medical Center, Stony Brook

16803

Mount Nittany Medical Center, State College

19001

Abington Memorial Hospital, Abington

19096

Lankenau Hospital, Wynnewood

19103

Radiation Therapy Oncology Group, Philadelphia

19301

Paoli Memorial Hospital, Paoli

19611

Reading Hospital, West Reading

19718

Christiana Care Health System-Christiana Hospital, Newark

19971

Beebe Health Campus, Rehoboth Beach

20010

Washington Hospital Center, Washington D.C.

20910

Holy Cross Hospital, Silver Spring

21204

Greater Baltimore Medical Center, Baltimore

21215

Sinai Hospital of Baltimore, Baltimore

21801

Peninsula Regional Medical Center, Salisbury

25701

Edwards Comprehensive Cancer Center, Huntington

28401

Coastal Carolina Radiation Oncology, Wilmington

New Hanover Regional Medical Center, Wilmington

28462

South Atlantic Radiation Oncology, Supply

29425

Medical University of South Carolina, Charleston

29646

Self Regional Healthcare, Greenwood

30041

Northside Hospital-Forsyth, Cumming

30303

Grady Health System, Atlanta

30309

Piedmont Hospital, Atlanta

30322

Emory University/Winship Cancer Institute, Atlanta

30342

Northside Hospital, Atlanta

30501

Northeast Georgia Medical Center, Gainesville

31405

Saint Joseph's-Candler Health System, Savannah

32209

University of Florida Health Science Center, Jacksonville

32610

University of Florida, Gainesville

33136

Jackson Memorial Hospital-Holtz Children's Hospital, Miami

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

43219

The Mark H Zangmeister Center, Columbus

44024

Geaugra Hospital, Chardon

44060

Lake University Ireland Cancer Center, Mentor

44106

Case Western Reserve University, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Orange

44130

Southwest General Health Center Ireland Cancer Center, Middleburg Heights

44145

UHHS-Westlake Medical Center, Westlake

44203

Summa Barberton Hospital, Barberton

44256

Summa Health Center at Lake Medina, Medina

44304

Summa Akron City Hospital/Cooper Cancer Center, Akron

45662

Southern Ohio Medical Center, Portsmouth

46016

Saint Vincent Anderson Regional Hospital/Cancer Center, Anderson

46311

Franciscan Saint Margaret Health-Dyer Campus, Dyer

46320

Franciscan Saint Margaret Health-Hammond Campus, Hammond

46804

Radiation Oncology Associates PC, Fort Wayne

48093

Saint John Macomb-Oakland Hospital, Warren

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Saint John Hospital and Medical Center, Detroit

49503

Mercy Health Saint Mary's, Grand Rapids

Spectrum Health at Butterworth Campus, Grand Rapids

50010

McFarland Clinic PC-William R Bliss Cancer Center, Ames

50309

Iowa Methodist Medical Center, Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

53215

Aurora Saint Luke's Medical Center, Milwaukee

53227

Aurora West Allis Medical Center, West Allis

55102

United Hospital, Saint Paul

55387

Ridgeview Medical Center, Waconia

56601

Sanford Clinic North-Bemidgi, Bemidji

57701

Rapid City Regional Hospital, Rapid City

58501

Sanford Bismarck Medical Center, Bismarck

60426

Ingalls Memorial Hospital, Harvey

60611

Northwestern University, Chicago

60612

University of Illinois, Chicago

60657

Advocate Illinois Masonic Medical Center, Chicago

63141

Saint John's Mercy Medical Center, St Louis

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

68198

The Nebraska Medical Center, Omaha

70121

Ochsner Medical Center Jefferson, New Orleans

70809

Mary Bird Perkins Cancer Center, Baton Rouge

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75390

University of Texas Southwestern Medical Center, Dallas

77030

M D Anderson Cancer Center, Houston

78229

University of Texas Health Science Center at San Antonio, San Antonio

80045

University of Colorado Cancer Center - Anschutz Cancer Pavilion, Aurora

80113

Swedish Medical Center, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80210

Porter Adventist Hospital, Denver

80501

Longmont United Hospital, Longmont

80539

McKee Medical Center, Loveland

80907

Penrose-Saint Francis Healthcare, Colorado Springs

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

84143

LDS Hospital, Salt Lake City

84157

Intermountain Medical Center, Murray

84321

Logan Regional Hospital, Logan

84770

Dixie Medical Center Regional Cancer Center, St. George

85027

Arizona Oncology-Deer Valley Center, Phoenix

85234

Banner MD Anderson Cancer Center, Gilbert

85260

Arizona Oncology Services Foundation, Scottsdale

87106

University of New Mexico, Albuquerque

91767

Pomona Valley Hospital Medical Center, Pomona

92093

UC San Diego Moores Cancer Center, La Jolla

92868

Saint Joseph Hospital - Orange, Orange

93720

California Cancer Center - North Fresno, Fresno

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

94611

Kaiser Permanente Oakland-Broadway, Oakland

94928

Rohnert Park Cancer Center, Rohnert Park

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95817

University of California at Davis Cancer Center, Sacramento

95823

South Sacramento Cancer Center, Sacramento

95969

Feather River Cancer Center, Paradise

96706

Leeward Radiation Oncology Center, ‘Ewa Beach

96813

Queen's Medical Center, Honolulu

University of Hawaii, Honolulu

96817

The Cancer Center of Hawaii-Liliha, Honolulu

98003

Saint Francis Hospital, Federal Way

98101

Virginia Mason CCOP, Seattle

119074

National University Hospital, Singapore

60612-3785

John H Stroger Jr Hospital of Cook County, Chicago

02115

Brigham and Women's Hospital, Boston

Dana-Farber Cancer Institute, Boston

02118

Boston Medical Center, Boston

01854

Lowell General Hospital, Lowell

01757

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford

02190

Dana-Farber/Brigham and Women's Cancer Center at South Shore, South Weymouth

01107

D'Amour Center for Cancer Care, Springfield

48106-0995

Saint Joseph Mercy Hospital, Ann Arbor

59107-7000

Billings Clinic, Billings

08060

Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County, Mount Holly

08534

Capital Health Medical Center-Hopewell, Pennington

08043

Virtua West Jersey Hospital Voorhees, Voorhees Township

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54311-6519

Aurora BayCare Medical Center, Green Bay

V1Y 5L3

BCCA-Cancer Centre for the Southern Interior, Kelowna

V8R 6V5

BCCA-Vancouver Island Cancer Centre, Victoria

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

N6A 4L6

London Regional Cancer Program, London

S4T 7T1

Allan Blair Cancer Centre, Regina

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

Unknown

Pamela Youde Nethersole Eastern Hospital, Chai Wan

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

NRG Oncology

OTHER

lead

Radiation Therapy Oncology Group

NETWORK