Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND)

PHASE3CompletedINTERVENTIONAL
Enrollment

1,651

Participants

Timeline

Start Date

December 20, 2012

Primary Completion Date

April 29, 2016

Study Completion Date

March 31, 2023

Conditions
Secondary Progressive Multiple Sclerosis
Interventions
DRUG

BAF312

0.25, 0.5, 1, and 2 mg film-coated tablets

DRUG

Placebo

Film-coated tablets

Trial Locations (290)

1010

Novartis Investigative Site, Vienna

1011

Novartis Investigative Site, Lausanne

1070

Novartis Investigative Site, Brussels

1085

Novartis Investigative Site, Budapest

1090

Novartis Investigative Site, Vienna

1106

Novartis Investigative Site, Budapest

1113

Novartis Investigative Site, Sofia

1135

Novartis Investigative Site, Budapest

1145

Novartis Investigative Site, Budapest

1204

Novartis Investigative Site, Budapest

1413

Novartis Investigative Site, Sofia

1424

Novartis Investigative Site, Capital Federal

1425

Novartis Investigative Site, CABA

1431

Novartis Investigative Site, Sofia

2050

Novartis Investigative Site, Camperdown

2170

Novartis Investigative Site, Liverpool

2217

Novartis Investigative Site, Kogarah

2500

Novartis Investigative Site, Esztergom

2650

Novartis Investigative Site, Edegem

2660

Novartis Investigative Site, Balassagyarmat

3000

Novartis Investigative Site, Leuven

3050

Novartis Investigative Site, Parkville

3084

Novartis Investigative Site, Heidelberg

3526

Novartis Investigative Site, Miskolc

3900

Novartis Investigative Site, Overpelt

4031

Novartis Investigative Site, Basel

4400

Novartis Investigative Site, Nyíregyháza

4557

Novartis Investigative Site, Fraiture En Condroz

5001

Novartis Investigative Site, Aarau

6000

Novartis Investigative Site, Lucerne

6900

Novartis Investigative Site, Lugano

8000

Novartis Investigative Site, Bruges

8091

Novartis Investigative Site, Zurich

8340

Novartis Investigative Site, Sijsele

9000

Novartis Investigative Site, Ghent

9007

Novartis Investigative Site, Sankt Gallen

9010

Novartis Investigative Site, Varna

9020

Novartis Investigative Site, Klagenfurt

10017

Novartis Investigative Site, New York

10029

Novartis Investigative Site, New York

10138

Novartis Investigative Site, Tallinn

10235

Novartis Investigative Site, Stockholm

10617

Novartis Investigative Site, Tallinn

10713

Novartis Investigative Site, Berlin

11772

Novartis Investigative Site, Patchogue

11794

Novartis Investigative Site, Stony Brook

12808

Novartis Investigative Site, Prague

13347

Novartis Investigative Site, Berlin

13885

Novartis Investigative Site, Marseille

14033

Novartis Investigative Site, Caen

14471

Novartis Investigative Site, Potsdam

15755

Novartis Investigative Site, Teupitz

16132

Novartis Investigative Site, Genova

18057

Novartis Investigative Site, Rostock

19104

Novartis Investigative Site, Philadelphia

20080

Novartis Investigative Site, Donostia / San Sebastian

20122

Novartis Investigative Site, Milan

20132

Novartis Investigative Site, Milan

20249

Novartis Investigative Site, Hamburg

21287

Novartis Investigative Site, Baltimore

21682

Novartis Investigative Site, Stade

22083

Novartis Investigative Site, Hamburg

25524

Novartis Investigative Site, Itzehoe

26122

Novartis Investigative Site, Oldenburg

28040

Novartis Investigative Site, Madrid

28207

Novartis Investigative Site, Charlotte

28222

Novartis Investigative Site, Madrid

29010

Novartis Investigative Site, Málaga

30029

Novartis Investigative Site, Nîmes

30120

Novartis Investigative Site, El Palmar

30171

Novartis Investigative Site, Hanover

30625

Novartis Investigative Site, Hanover

32174

Novartis Investigative Site, Ormond Beach

32209

Novartis Investigative Site, Jacksonville

32751

Novartis Investigative Site, Maitland

32960

Novartis Investigative Site, Vero Beach

33024

Novartis Investigative Site, Hollywood

33076

Novartis Investigative Site, Bordeaux

33445

Novartis Investigative Site, Delray Beach

33609

Novartis Investigative Site, Tampa

33612

Novartis Investigative Site, Tampa

33647

Novartis Investigative Site, Bielefeld

33952

Novartis Investigative Site, Port Charlotte

34096

Novartis Investigative Site, Haseki Istanbul

34098

Novartis Investigative Site, Istanbul

34121

Novartis Investigative Site, Kassel

34295

Novartis Investigative Site, Montpellier

34394

Novartis Investigative Site, Mecidiyekoy Istanbul

34662

Novartis Investigative Site, Altunizade

35043

Novartis Investigative Site, Rennes

41009

Novartis Investigative Site, Seville

41380

Novartis Investigative Site, Kocaeli

44320

Novartis Investigative Site, Akron

44791

Novartis Investigative Site, Bochum

44800

Novartis Investigative Site, Saint-Herblain

45408

Novartis Investigative Site, Dayton

46010

Novartis Investigative Site, Valencia

46026

Novartis Investigative Site, Valencia

48013

Novartis Investigative Site, Bilbao

48109

Novartis Investigative Site, Ann Arbor

48149

Novartis Investigative Site, Münster

48201

Novartis Investigative Site, Detroit

52621

Novartis Investigative Site, Ramat Gan

53111

Novartis Investigative Site, Bonn

53215

Novartis Investigative Site, Milwaukee

54035

Novartis Investigative Site, Nancy

55139

Novartis Investigative Site, Samsun

55446

Novartis Investigative Site, Plymouth

57076

Novartis Investigative Site, Siegen

59037

Novartis Investigative Site, Lille

60201

Novartis Investigative Site, Evanston

60313

Novartis Investigative Site, Frankfurt

60422

Novartis Investigative Site, Flossmoor

60612

Novartis Investigative Site, Chicago

61080

Novartis Investigative Site, Trabzon

63131

Novartis Investigative Site, St Louis

63739

Novartis Investigative Site, Aschaffenburg

64711

Novartis Investigative Site, Erbach im Odenwald

65191

Novartis Investigative Site, Wiesbaden

66212

Novartis Investigative Site, Lenexa

66421

Novartis Investigative Site, Homburg

67091

Novartis Investigative Site, Strasbourg

69120

Novartis Investigative Site, Heidelberg

71032

Novartis Investigative Site, Böblingen

72076

Novartis Investigative Site, Tübingen

75216

Novartis Investigative Site, Dallas

75651

Novartis Investigative Site, Paris

78258

Novartis Investigative Site, San Antonio

79106

Novartis Investigative Site, Freiburg im Breisgau

79410

Novartis Investigative Site, Lubbock

80045

Novartis Investigative Site, Aurora

80113

Novartis Investigative Site, Englewood

80131

Novartis Investigative Site, Napoli

80301

Novartis Investigative Site, Boulder

80377

Novartis Investigative Site, München

80907

Novartis Investigative Site, Colorado Springs

81621

Novartis Investigative Site, Basalt

82008

Novartis Investigative Site, Unterhaching

82335

Novartis Investigative Site, Berg

83209

Novartis Investigative Site, Prien am Chiemsee

85032

Novartis Investigative Site, Phoenix

86633

Novartis Investigative Site, Neuburg an der Donau

88477

Novartis Investigative Site, Schwendi

89073

Novartis Investigative Site, Ulm

89081

Novartis Investigative Site, Ulm

89106

Novartis Investigative Site, Las Vegas

90015

Novartis Investigative Site, Cefalù

90033

Novartis Investigative Site, Los Angeles

91054

Novartis Investigative Site, Erlangen

91171

Novartis Investigative Site, Trenčín

92056

Novartis Investigative Site, Oceanside

93053

Novartis Investigative Site, Regensburg

94705

Novartis Investigative Site, Berkeley

94911

Novartis Investigative Site, Nitra

95445

Novartis Investigative Site, Bayreuth

95817

Novartis Investigative Site, Sacramento

97080

Novartis Investigative Site, Würzburg

97225

Novartis Investigative Site, Portland

97477

Novartis Investigative Site, Springfield

97517

Novartis Investigative Site, Banská Bystrica

97980

Novartis Investigative Site, Bad Mergentheim

98101

Novartis Investigative Site, Seattle

98122

Novartis Investigative Site, Seattle

100028

Novartis Investigative Site, Beijing

100034

Novartis Investigative Site, Beijing

100730

Novartis Investigative Site, Beijing

119049

Novartis Investigative Site, Moscow

127018

Novartis Investigative Site, Moscow

130021

Novartis Investigative Site, Changchun

194044

Novartis Investigative Site, Saint Petersburg

197110

Novartis Investigative Site, Saint Petersburg

197376

Novartis Investigative Site, Saint Petersburg

200040

Novartis Investigative Site, Shanghai

300736

Novartis Investigative Site, Timișoara

420043

Novartis Investigative Site, Kazan'

450000

Novartis Investigative Site, Ufa

540136

Novartis Investigative Site, Târgu Mureş

610041

Novartis Investigative Site, Chengdu

630007

Novartis Investigative Site, Novosibirsk

656024

Novartis Investigative Site, Barnaul

710038

Novartis Investigative Site, Xi’an

727525

Novartis Investigative Site, Suceava

900591

Novartis Investigative Site, Constanța

2608677

Novartis Investigative Site, Chiba

4710243

Novartis Investigative Site, Braga

9112001

Novartis Investigative Site, Jerusalem

06824

Novartis Investigative Site, Fairfield

48202 2689

Novartis Investigative Site, Detroit

03756

Novartis Investigative Site, Lebanon

07728

Novartis Investigative Site, Freehold

87131-0001

Novartis Investigative Site, Albuquerque

02905

Novartis Investigative Site, Providence

05401

Novartis Investigative Site, Burlington

C1181ACH

Novartis Investigative Site, CABA

C1428AQK

Novartis Investigative Site, CABA

C1424BYD

Novartis Investigative Site, Buenos Aires

X5000FAL

Novartis Investigative Site, Córdoba

T2N 2T9

Novartis Investigative Site, Calgary

T6G 2G3

Novartis Investigative Site, Edmonton

V5G 2X6

Novartis Investigative Site, Burnaby

B3H 4K4

Novartis Investigative Site, Halifax

K7L 2V7

Novartis Investigative Site, Kingston

K1H 8L6

Novartis Investigative Site, Ottawa

M4N 3M5

Novartis Investigative Site, Toronto

J4V 2J2

Novartis Investigative Site, Greenfield Park

H2X 0A9

Novartis Investigative Site, Montreal

H3A 2B4

Novartis Investigative Site, Montreal

030001

Novartis Investigative Site, Taiyuan

625 00

Novartis Investigative Site, Brno

415 01

Novartis Investigative Site, Teplice

586 01

Novartis Investigative Site, Jihlava

150 00

Novartis Investigative Site, Prague

01307

Novartis Investigative Site, Dresden

07740

Novartis Investigative Site, Jena

04103

Novartis Investigative Site, Leipzig

04107

Novartis Investigative Site, Leipzig

07646

Novartis Investigative Site, Stadtroda

106 76

Novartis Investigative Site, Athens

711 10

Novartis Investigative Site, Heraklion Crete

GR 54636

Novartis Investigative Site, Thessaloniki

H-3300

Novartis Investigative Site, Eger

H 8200

Novartis Investigative Site, Veszprém

D04 T6F

Novartis Investigative Site, Dublin

D09

Novartis Investigative Site, Dublin

00133

Novartis Investigative Site, Roma

00152

Novartis Investigative Site, Roma

00161

Novartis Investigative Site, Roma

00168

Novartis Investigative Site, Roma

00179

Novartis Investigative Site, Roma

791-0295

Novartis Investigative Site, Tōon

070-8644

Novartis Investigative Site, Asahikawa

020-8505

Novartis Investigative Site, Morioka

616-8147

Novartis Investigative Site, Kyoto

565 0871

Novartis Investigative Site, Suita

350 8550

Novartis Investigative Site, Kawagoe

359 8513

Novartis Investigative Site, Tokorozawa

187-8551

Novartis Investigative Site, Kodaira

145-0065

Novartis Investigative Site, Ōta-ku

162 8666

Novartis Investigative Site, Shinjuku Ku

160 8582

Novartis Investigative Site, Shinjuku-ku

030 8553

Novartis Investigative Site, Aomori

556-0016

Novartis Investigative Site, Osaka

LV-1005

Novartis Investigative Site, Riga

LV 1002

Novartis Investigative Site, Riga

LV-1038

Novartis Investigative Site, Riga

LT 50161

Novartis Investigative Site, Kaunas

LT-92288

Novartis Investigative Site, Klaipėda

LT-08661

Novartis Investigative Site, Vilnius

1105 AZ

Novartis Investigative Site, Amsterdam

4818 CK

Novartis Investigative Site, Breda

5623 EJ

Novartis Investigative Site, Eindhoven

1624 NP

Novartis Investigative Site, Hoorn

6162 BG

Novartis Investigative Site, Sittard-Geleen

5022 GC

Novartis Investigative Site, Tilburg

26 200

Novartis Investigative Site, Gmina Końskie

86 300

Novartis Investigative Site, Grudziądz

40 571

Novartis Investigative Site, Katowice

25 726

Novartis Investigative Site, Kielce

31-637

Novartis Investigative Site, Krakow

90 324

Novartis Investigative Site, Lodz

60-355

Novartis Investigative Site, Poznan

02-957

Novartis Investigative Site, Warsaw

2720-276

Novartis Investigative Site, Amadora

3000 075

Novartis Investigative Site, Coimbra

1649 035

Novartis Investigative Site, Lisbon

4099-001

Novartis Investigative Site, Porto

020125

Novartis Investigative Site, Bucharest

050098

Novartis Investigative Site, Bucharest

813 69

Novartis Investigative Site, Bratislava

826 06

Novartis Investigative Site, Bratislava

036 59

Novartis Investigative Site, Martin

081 81

Novartis Investigative Site, Prešov

917 75

Novartis Investigative Site, Trnava

08907

Novartis Investigative Site, L'Hospitalet de Llobregat

08916

Novartis Investigative Site, Badalona

08003

Novartis Investigative Site, Barcelona

08035

Novartis Investigative Site, Barcelona

08041

Novartis Investigative Site, Barcelona

413 45

Novartis Investigative Site, Gothenburg

102 35

Novartis Investigative Site, Stockholm

M6 8HD

Novartis Investigative Site, Salford

OX3 9DU

Novartis Investigative Site, Headington

S10 2JF

Novartis Investigative Site, Sheffield

BS10 5NB

Novartis Investigative Site, Bristol

G51 4TF

Novartis Investigative Site, Glasgow

LS1 3EX

Novartis Investigative Site, Leeds

LE5 4PW

Novartis Investigative Site, Leicester

EC1A 7BE

Novartis Investigative Site, London

W8 6RF

Novartis Investigative Site, London

NE1 4LP

Novartis Investigative Site, Newcastle upon Tyne

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