Study of Dexamethasone Plus IXAZOMIB (MLN9708) or Physicians Choice of Treatment in Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis

PHASE3TerminatedINTERVENTIONAL
Enrollment

177

Participants

Timeline

Start Date

December 26, 2012

Primary Completion Date

July 11, 2022

Study Completion Date

July 11, 2022

Conditions
Relapsed or Refractory Systemic Light Chain Amyloidosis
Interventions
DRUG

IXAZOMIB

IXAZOMIB capsules

DRUG

Dexamethasone

Dexamethasone tablets

DRUG

Melphalan

Melphalan tablets

DRUG

Cyclophosphamide

Cyclophosphamide tablets

DRUG

Thalidomide

Thalidomide capsules

DRUG

Lenalidomide

Lenalidomide capsules

Trial Locations (66)

214

Westmead Hospital, Westmead

620

Maastricht University Medical Center, AZ Maastricht

800

Arhus Universitetshospital Arhus Sygehus, Aahus

911

Hadasit Medical Research Services and Development Ltd, Jerusalem

2100

Rigshospitalet, Copenhagen

2710

Fondazione IRCCS Policlinico San Matteo di Pavia, Pavia

3128

Box Hill Hospital, Box Hill

3508

Universitair Medisch Centrum Utrecht, Utrecht

4102

Princess Alexandra Hospital, Woolloongabba

5903

Hopital Claude Huriez, Lille

6009

Sir Charles Gairdner Hospital, Nedlands

8036

Hospital Clinic de Barcelona, Barcelona

10032

Columbia University Medical Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

11528

Alexandra Hospital, Athens

12200

Charite - Universitatsmedizin Berlin, Berlin

20246

Universitatsklinikum Hamburg Eppendorf, Hamburg

26500

University General Hospital of Patras, Pátrai

28006

Hospital Universitario de La Princesa, Madrid

28222

Hospital Universitario Puerta de Hierro - Majadahonda, Majadahonda

31008

Clinica Universidad de Navarra, Pamplona

31059

Hopital de Rangueil, Toulouse

31096

Rambam Health Corporation, Haifa

37007

Hospital Universitario de Salamanca, Salamanca

37232

Vanderbilt University Medical Center, Nashville

40138

"Institute of Hematology Seragnoli University of Bologna", Bologna

44093

Hotel Dieu, Nantes

44195

Cleveland Clinic, Cleveland

44281

Meir Medical Center, Kfar Saba

45267

University of Cincinnati, Cincinnati

46202

Indiana University School of Medicine, Indianapolis

48201

Karmanos Cancer Institute, Detroit

49100

Rabin Medical Center - PPDS, Petah Tikva

52621

Chaim Sheba Medical Center, Ramat Gan

53226

Froedtert and The Medical College of Wisconsin, Milwaukee

60637

University of Chicago, Chicago

63110

Washington University, St Louis

69120

Universitat Heidelberg, Heidelberg

75010

Hopital Saint Louis, Paris

75390

University of Texas Southwestern Medical Center, Dallas

87042

Centre Hospitalier et Universitaire de Limoges, Limoges

90048

Cedars Sinai Medical Center, Los Angeles

110744

Seoul National University Hospital, Seoul

5403000

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo

00211

Tufts Medical Center, Boston

02118

Boston Medical Center, Boston

05590

Mayo Clinic, Rochester

88034-000

Centro de Pesquisas Oncologicas, Florianópolis

21941-913

Hospital Universitario Clementino Fraga Filho (UFRJ), Rio de Janeiro

01223-001

Irmandade Da Santa Casa de Misericordia de Sao Paulo, São Paulo

05652-900

Hospital Israelita Albert Einstein, São Paulo

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z

Cross Cancer Institute, Edmonton

V5Z 1M

Vancouver General Hospital, Vancouver

M5G2M9

Princess Margaret Hospital, Toronto

708 52

Fakultni nemocnice Ostrava, Ostrava

128 08

Vseobecna fakultni nemocnice v Praze, Prague

1081 HV

VU Medisch Centrum, Amsterdam

405-760

Gachon University Gil Medical Center, Incheon

120-752

Severance Hospital at Yonsei University Health System - PPDS, Seoul

135-710

Samsung Medical Center - PPDS, Seoul

137-70

The Catholic University of Korea, Seoul St Mary's Hospital, Seoul

B152TH

Queen Elizabeth Hospital, Birmingham

NW3 2P

Royal Free and University College Medical School, London

MI3 9WL

Manchester Royal Infirmary, Manchester

OX3 7L

Oxford University Hospitals NHS Trust, Oxford

All Listed Sponsors
lead

Millennium Pharmaceuticals, Inc.

INDUSTRY

NCT01659658 - Study of Dexamethasone Plus IXAZOMIB (MLN9708) or Physicians Choice of Treatment in Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis | Biotech Hunter | Biotech Hunter