An MRI-guided Treatment Strategy to Prevent Disease Progression in Patients With Rheumatoid Arthritis

NACompletedINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

March 31, 2012

Primary Completion Date

May 31, 2017

Study Completion Date

May 31, 2017

Conditions
ArthritisArthritis, RheumatoidJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesAutoimmune Diseases
Interventions
PROCEDURE

Magnetic resonance imaging (MRI)

"Treatment algorithm based on conventional biochemical/clinical examinations AND MRI of unilateral 2nd to 5th MCP joints and wrist on dominant side. Assessed month 0, 4, 8, 12, 16, 20, 24 with treatment intensification after predefined treatment algorithm in the case of unsatisfactory inflammatory activity, which is defined as the presence of at least one physically swollen joint and DAS28\>3.2 AND/OR MRI-detected bone marrow oedema score \> 0 (RAMRIS-score)"

OTHER

Conventional biochemical and clinical examinations

"Treatment algorithm based on conventional biochemical and clinical examinations. Assessed month 0, 4, 8, 12, 16, 20, 24 with treatment intensification after predefined treatment algorithm in the case of unsatisfactory inflammatory activity, which is defined as the presence of at least one clinically swollen joint and DAS28\>3.2"

Trial Locations (9)

2000

Dep. of Rheumatology Frederiksberg Hospital, Copenhagen

2600

Dep. of Rheumatology Glostrup Hospital, Copenhagen

2900

Dep. of Rheumatology Gentofte Hospital, Copenhagen

4200

Dep. of Rheumatology Slagelse Hospital, Slagelse

5000

Dep. of rheumatology Odense Hospital, Odense

6300

Dep. of Rheumatology King Christian X´Hospital for Rheumatic Diseases, Gråsten

8600

Dep. of Rheumatology Aarhus Hospital, Aarhus

Dep. of Rheumatology Silkeborg Hospital, Silkeborg

DK-9800

Department of Rheumatology University Hospital Vendsyssel, Hjørring

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

King Christian X´Hospital for Rheumatic Diseases

OTHER

collaborator

Slagelse Hospital

OTHER

collaborator

Glostrup University Hospital, Copenhagen

OTHER

collaborator

Abbott

INDUSTRY

lead

Professor of Rheumatology, MD, DMSci, Kim Horslev-Petersen

OTHER

NCT01656278 - An MRI-guided Treatment Strategy to Prevent Disease Progression in Patients With Rheumatoid Arthritis | Biotech Hunter | Biotech Hunter