Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC)

PHASE3TerminatedINTERVENTIONAL
Enrollment

307

Participants

Timeline

Start Date

June 30, 2012

Primary Completion Date

October 31, 2013

Study Completion Date

October 31, 2013

Conditions
Chronic Myeloid Leukemia
Interventions
DRUG

ponatinib

45 mg tablet, taken orally once daily

DRUG

imatinib (Gleevec/ Glivec)

400 mg tablet, taken orally once daily

Trial Locations (170)

144

U.O. di Ematologia - Ospedale S. Eugenio, Site #962, Rome

1023

Auckland City Hospital, Site #921, Grafton

2065

Royal North Shore Hospital, Site #941, Sydney

2605

Canberra Hospital, Site #971, Garran

3000

Clinique Universitaire de Saint-Luc, Department of Haematology, Site #508, Brussels

UZ Gasthuisberg - Department of Hematology, Site #700, Leuven

3002

The Peter MacCallum Cancer Center, Site #950, East Melbourne

3128

Box Hill Hospital, Site #940, Melbourne

5000

Royal Adelaide Hospital, Site #951, Adelaide

5001

Kantonsspital Aarau, Site #541, Aarau

6000

Royal Perth Hospital, Site #972, Perth

9007

Kantonsspital St. Gallen, Site #707, Sankt Gallen

10002

National Taiwan University Hospital, Site #979, Taipei

10003

Beth Israel Medical Center, Site #145, New York

10029

Mount Sinai School of Medicine, Site #189, New York

10043

SCDU Medicina Interna II - Indirizzo Ematologico, Site #785, Orbassano

10065

Memorial Sloan-Kettering Cancer Center, Site #078, New York

Weill Cornell Medical College, Site #006, New York

10595

New York Medical College, Site #146, Valhalla

11220

Maimonides Cancer Center, Site #177, Brooklyn

11501

Winthrop University Hospital, Site #153, Mineola

12808

Ustav hematologie a krevni transfuse, Site #516, Prague

13353

Charite - Universitatsmedizin Berlin, Site #701, Berlin

15006

"Complejo Hospitalario Universitario A Coruna, Hospital Teresa Herrera, Site #554", A Coruña

15224

Western Pennsylvania Hospital, Site #159, Pittsburgh

16132

Clinica Ematologica, Site #528, Genova

17007

Institut Catala d' Oncologia de Girona, S. de Hematologia Clinica, Site #734, Girona

17325

Gettysburg Cancer Center, Site #160, Gettysburg

19713

Christiana Care Health Services, Site #155, Newark

20162

Ospedale Niguarda Ca' Granda di Milano, Site #531, Milan

20246

Universitatsklinikum Hamburg-Eppendorf, Site #524, Hamburg

20900

San Gerardo Hospital, Site #961, Monza

21201

University of Maryland, Greenebaum Cancer Center, Site #040, Baltimore

21204

Greater Baltimore Medical Center, Site #140, Baltimore

21229

St. Agnes Healthcare, Site #185, Baltimore

23298

VCU Massey Cancer Center, Dalton Oncology Clinic, Site #069, Richmond

26506

West Virginia University, Site #154, Morgantown

27534

Southeastern Medical Oncology Center, Site #188, Goldsboro

28006

Hospital Universitario La Princesa, Site #555, Madrid

28007

Hospital Gregorio Maranon, Site #536, Madrid

28034

H.U. Ramon y Cajal, Site #538, Madrid

28041

Hospital Universitario 12 de Octubre, Site #537, Madrid

28046

Hospital La Paz, Site #966, Madrid

29150

Carolina Hematology Oncology, Site #143, Sumter

29200

CHRU de Brest, Hopital Morvan, Site #523, Brest

29425

Medical University of South Carolina, Site #148, Charleston

30322

Emory University, Site #058, Atlanta

33006

Hospital Universitario Central de Asturias, Site #535, Oviedo

33426

University Cancer Institute, Site #149, Boynton Beach

33705

Florida Cancer Specialists, Site #179, St. Petersburg

33916

Florida Cancer Specialists, Site #180, Fort Meyers

37007

Hospital Universitario de Salamanca, Site #965, Salamanca

37203

Sarah Cannon Research Institute, Site #076, Nashville

37421

Associates in Oncology & Hematology, Site #186, Chattanooga

40138

"Istituto di Ematologia L. & A. Seragnoli, Site #959", Bologna

40447

China Medical University Hospital, Site #978, Taiching

41124

S.C. Ematologia, Site #960, Modena

44093

CHU de Nantes, Site #521, Nantes

45042

Signal Point Clinical Research Center, Site #139, Middletown

46010

Hospital Clinico Universitario de Valencia, Site #964, Valencia

46237

Franciscan St. Francis Health, Site #138, Indianapolis

48075

Providence Cancer Institute, Site #197, Southfield

48109

University of Michigan Medical Center, Site #011, Ann Arbor

50005

FN Hradec Kralove, Site #517, Hradec Králové

50937

Universitatsklinikum Koln-AOR, Site #525, Cologne

51101

Siouxland Hematology-Oncology Associates, Site #198, Sioux City

52074

Universitätsklinikum Aachen, AÖR, Site #513, Aachen

52242

University of Iowa Hospitals and Clinics, Site #050, Iowa City

53792

University of Wisconsin, Site #030, Madison

54303

Green Bay Oncology, Ltd. / St. Mary's Hospital Medical Center, Site #193, Green Bay

55426

Oncology Research Park Nicollet Institute, Site #195, Saint Louis Park

55905

Mayo Clinic, Site #044, Rochester

59037

Hospital Claude Huriez, Site #952, Lille

60153

Loyola University Chicago, Site #054, Maywood

60612

John H. Stroger, Jr. Hospital of Cook County, Site #192, Chicago

60637

University of Chicago, Site #001, Chicago

62500

Fakultni nemocnice Brno, Interni hematologicka a onkologicka klinika, Site #514, Brno

64111

Saint Luke's Hospital, Site #162, Kansas City

65804

Mercy Clinic - Cancer & Hematology, Site #151, Springfield

67214

US Oncology - Cancer Center of Kansas, Site #168, Wichita

68167

Universitat Heidelberg, CML - Studienzentrale III. Medizinische Klinik, Site #947, Mannheim

68506

Nebraska Hematology-Oncology, P.C., Site # 133, Lincoln

69495

Centre Hospitalier Lyon Sud, Site #956, Pierre-Bénite

70124

Unita Operativa di Ematologia con Trapianto, Site #529, Bari

71103

Willis-Knighton Cancer Center, Site #196, Shreveport

73104

University of Oklahoma, Site #028, Oklahoma City

75231

US Oncology - Texas Oncology Dallas, Site #171, Dallas

75390

University of Texas Southwestern Medical Center, Site #178, Dallas

75475

Hopital Saint-Louis, Site #957, Paris

77030

Baylor College of Medicine, Site #063, Houston

77520

Fakultni nemocnice Olomouc, Hematoonkologicka klinika, Site #515, Olomouc

78229

US Oncology - Cancer Care Center of South Texas, Site #170, San Antonio

78705

US Oncology - Texas Oncology Austin, Site #172, Austin

79701

US Oncology - Texas Oncology Midland, Site #173, Midland

80131

U.O.C Ematologia con trapianto di midollo osseo, Site #560, Napoli

80303

Rocky Mountain Cancer Centers, Site #191, Boulder

81675

Klinikum rechts der Isar, Site #949, München

84112

Huntsman Cancer Institute, Site #043, Salt Lake City

86021

CHU de Poitiers, Site #954, Poitiers

87106

University of New Mexico Cancer Center, Site #166, Albuquerque

89169

US Oncology - Comprehensive Cancer Center of Nevada, Site #169, Las Vegas

90095

UCLA Department of Medicine, Site #027, Los Angeles

91505

US Oncology - Providence Health System, Site #167, Burbank

94010

CHU Henri Mondor, Site #520, Créteil

94523

Bay Area Cancer Research Group, Site #156, Pleasant Hill

Bay Area Cancer Research Group, Site #157, Pleasant Hill

95124

A.O. Universitaria Policlinico Vittorio Emanuele di Catania, Site #530, Catania

97213

Providence Cancer Center Oncology and Hematology Care Eastside, Site #194, Portland

97227

Kaiser Permanente Northwest, Site #200, Portland

97239

Oregon Health & Science University, Site #048, Portland

98109

Seattle Cancer Care Alliance, Site #100, Seattle

98684

US Oncology - Northwest Cancer Specialists, Site #174, Vancouver

06489

Cancer Center of Central Connecticut, Site #147, Southington

02114

Massachusetts General Hospital, Site #047, Boston

02215

Dana Farber Cancer Institute, Site #008, Boston

01655

University of Massachusetts Worcester, Site #152, Worcester

07601

John Theurer Cancer Center, Site #128, Hackensack

01090

Medizinische Universitat Wien / AKH, Universitatsklinik fur Inniere Medizin I, Site #561, Vienna

Unknown

UZ Brussel - Department Hematology, Site #544, Brussels

UZ Gent - Department Hematology, Site #756, Ghent

Helsinki University Central Hospital, Site #542, Helsinki

Institut Bergonie, Site #772, Bordeaux

Centre Hospitalier de Versailles, Site #958, Le Chesnay

Institut Paoli Calmette, Site #519, Marseille

CHU de Brabois, Site #953, Nancy

Hospital Saint Antoine, Site #518, Paris

CHU Purpan, Site #955, Toulouse

Universitatsklinikum Freiburg, Site #527, Freiburg im Breisgau

Prince of Wales Hospital, Site #974, Hong Kong

Queen Mary Hospital, Site #973, Hong Kong

Universita Federico II, Site #510, Napoli

Christchurch Hospital, Site #922, Christchurch

Waikato Hospital, Site #977, Hamilton

Klinika Hematologii i Transplantologii, Uniwersyteckie Centrum Medyczne, Site #548, Gdansk

Malopolskie Centrum Medyczne, Site #546, Krakow

Klinika Hematologii Wojewodzkiego Szpitala Specjalistycznego, Site #550, Lodz

Katedra i Klinika Hematologii, Site #547, Wroclaw

Singapore General Hospital, Site #939, Singapore

Skane University Hospital, Site #944, Lund

Karolinska University Hospital Huddinge, Site #534, Stockholm

Karolinska University Hospital Solna, Site #763, Stockholm

Uppsala University Hospital, Site #945, Uppsala

Kaohsiung Chang Gung Memorial Hospital, Site #980, Kaohsiung City

Kent and Medway Cancer Research Network, Site #558, Gillingham

Hammersmith Hospital, Site #967, London

Newcastle University, Site #970, Newcastle

Norfolk & Norwich University Hospital Foundation Trust, Site #557, Norwich

Oxford University Hospitals NHS Trust, Site #543, Oxford

M5G 2M9

University Health Network, Princess Margaret Hospital, Site #083, Toronto

H3T 1E2

Jewish General Hospital, Site #129, Montreal

06202

Service Hematologie - Hospital Archet I, Site #509, Nice

01307

Universitatsklinikum Carl Gustav Carus an der TU Dresden, Site #526, Dresden

07747

Universitatsklinikum Jena, Site #946, Jena

00161

Dipartimento di Biotecnologie Cellulari ed Ematologia Universita La Sapienza - Policlinico Umberto I, Site #511, Rome

1081-HV

VU Medical Centre - Department Haematology, Site #948, Amsterdam

0740

North Shore Hospital, Site #976, Takapuna

35-055

Oddzial Hematologii, Site #551, Rzeszów

1099-023

Instituto Portugues de Oncologia, Site #545, Lisbon

00927

Fundacion de Investigacion de Diego, Site #199, San Juan

833 10

Narodny onkologicky ustav, Site #532, Bratislava

036 59

Univerzitna nemocnica Martin, Site #533, Martin

137-701

The Catholic University of Korea, Site #938, Seocho-gu

08916

Hospital Universitari Germans Trias i Pujol, Site #512, Badalona

08036

Hospital Clinic, Site #963, Barcelona

07010

Hospital Universitari Son Espases, Site #553, Islas Baleares

EH4 2XU

Western General Hospital, Site #556, Edinburgh

G120SB

University of Glasgow, Site #797, Glasgow

LS9 7TF

St. James University Hospital, Site #540, Leeds

L7 8XP

Royal Liverpool University Hospital, Site #969, Liverpool

NG5 1PB

Nottingham University Hospitals NHS Trust, Site #968, Nottingham

Sponsors
All Listed Sponsors
lead

Ariad Pharmaceuticals

INDUSTRY

NCT01650805 - Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC) | Biotech Hunter | Biotech Hunter