4
Participants
Start Date
November 30, 2012
Primary Completion Date
December 31, 2016
Study Completion Date
December 31, 2016
Interferon-gamma, Recombinant
Interferon-gamma (Immukine, Boehringer-Ingelheim, Alkmaar, the Netherlands), 100mcg subcutaneously, on days 0-2-4-7-9-11. Interferon-gamma treatment will be initiated when the noradrenalin dose is reduced to 50% of maximum dose, ensuring that the sepsis-induced pro-inflammatory phase has passed
Saline 0.9%
subcutaneous administration on days 0, 2, 4, 7, 9, and 11.
Radboud University Nijmegen Medical Centre, Nijmegen
Radboud University Medical Center
OTHER