High Dose Chemotherapy in Oligo-metastatic Homologous Recombination Deficient Breast Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

74

Participants

Timeline

Start Date

September 30, 2014

Primary Completion Date

January 31, 2023

Study Completion Date

October 31, 2026

Conditions
Breast Cancer
Interventions
DRUG

carboplatin, thiotepa, and cyclophosphamide

tandem intermediate-dose alkylating therapy: carboplatin 800 mg/m2, thiotepa 240 mg/m2, and cyclophosphamide 3000 mg/m2) with PBPC-reinfusion.

DRUG

chemotherapy (docetaxel, doxorubicin, cyclofosfamide, carboplatin, paclitaxel, gemcitabine)

"* chemotherapy naïve;three cycles of docetaxel, doxorubicin, and cyclofosfamide~* chemotherapy naïve;1 cycle of dose-dense Adriamycin and cyclophosphamide followed by 4 cycles of carboplatin and paclitaxel~* previously received anthracyclines without taxanes;three cycles of carboplatin and paclitaxel~* previously received anthracyclines and taxanes;three cycles of carboplatin and gemcitabine"

Trial Locations (1)

1066 CX

NKI-AVL, Amsterdam

All Listed Sponsors
lead

The Netherlands Cancer Institute

OTHER