A Phase III Study of BKM120 With Fulvestrant in Patients With HR+,HER2-, AI Treated, Locally Advanced or Metastatic Breast Cancer Who Progressed on or After mTORi

PHASE3TerminatedINTERVENTIONAL
Enrollment

432

Participants

Timeline

Start Date

October 3, 2012

Primary Completion Date

May 23, 2016

Study Completion Date

September 21, 2017

Conditions
Metastatic Breast Cancer
Interventions
DRUG

Fulvestrant

Intramuscular fulvestrant 500 mg (Day 1 and Day 15 of Cycle 1 and Day 1 of every cycle thereafter)

DRUG

BKM120

BKM120 100 mg once daily

DRUG

BKM120 matching placebo

BKM120 matching placebo, once daily

Trial Locations (197)

652

Novartis Investigative Site, Saida

1000

Novartis Investigative Site, Brussels

1134

Novartis Investigative Site, Budapest

1303

Novartis Investigative Site, Sofia

1527

Novartis Investigative Site, Sofia

1756

Novartis Investigative Site, Sofia

3000

Novartis Investigative Site, Leuven

Novartis Investigative Site, Vratsa

4000

Novartis Investigative Site, Liège

Novartis Investigative Site, Plovdiv

4004

Novartis Investigative Site, Plovdiv

4010

Novartis Investigative Site, Linz

5000

Novartis Investigative Site, Namur

5020

Novartis Investigative Site, Salzburg

5021

Novartis Investigative Site, Bergen

5800

Novartis Investigative Site, Maastricht

6020

Novartis Investigative Site, Innsbruck

8500

Novartis Investigative Site, Rio Negro

9010

Novartis Investigative Site, Varna

10015

Novartis Investigative Site, Ivrea

10060

Novartis Investigative Site, Candiolo

10126

Novartis Investigative Site, Torino

10226

Novartis Investigative Site, Olsztyn

10400

Novartis Investigative Site, Bangkok

10408

Novartis Investigative Site, Gyeonggi-do

10467

Montefiore Medical Center Montefiore, The Bronx

11042

Clinical Research Alliance BKM120F2303, Lake Success

Clinical Research Alliance, Lake Success

12002

Novartis Investigative Site, Castellon

12203

Novartis Investigative Site, Berlin

15006

Novartis Investigative Site, A Coruña

15123

Novartis Investigative Site, Marousi

15232

University of Pittsburgh Cancer Institute Dept of Magee Women's Hospital, Pittsburgh

15706

Novartis Investigative Site, Santiago de Compostela

18547

Novartis Investigative Site, Athens

20121

Novartis Investigative Site, Milan

20132

Novartis Investigative Site, Milan

20141

Novartis Investigative Site, Milan

20900

Novartis Investigative Site, Monza

21201

University of Maryland Medical Center Univ Maryland, Baltimore

22015

Novartis Investigative Site, Saint-Brieuc Cédex

23007

Novartis Investigative Site, Jaén

23900

Novartis Investigative Site, Lecco

24103

Novartis Investigative Site, Kiel

25123

Novartis Investigative Site, Brescia

26100

Novartis Investigative Site, Cremona

26789

Novartis Investigative Site, Leer

27100

Novartis Investigative Site, Pavia

28007

Novartis Investigative Site, Madrid

28034

Novartis Investigative Site, Madrid

28040

Novartis Investigative Site, Madrid

28041

Novartis Investigative Site, Madrid

28046

Novartis Investigative Site, Madrid

28222

Novartis Investigative Site, Madrid

29010

Novartis Investigative Site, Málaga

30035

Novartis Investigative Site, Mirano

30322

Emory University School of Medicine/Winship Cancer Institute Emory, Atlanta

30607

University Cancer & Blood Center, LLC, Athens

33170

Novartis Investigative Site, Pordenone

35100

Novartis Investigative Site, Padua

36043

Novartis Investigative Site, Fulda

36688

University of South Alabama / Mitchell Cancer Institute Univ South AL, Mobile

37126

Novartis Investigative Site, Verona

38009

Novartis Investigative Site, Santa Cruz de Tenerife

38120

The West Clinic Dept. of the West Clinic, Memphis

38320

Novartis Investigative Site, San Cristóbal de La Laguna

39120

Novartis Investigative Site, Magdeburg

41009

Novartis Investigative Site, Seville

41124

Novartis Investigative Site, Modena

42551

Novartis Investigative Site, Velbert

43100

Novartis Investigative Site, Parma

44100

Novartis Investigative Site, Cona

44805

Novartis Investigative Site, Saint-Herblain Cédex

45136

Novartis Investigative Site, Essen

45147

Novartis Investigative Site, Essen

46009

Novartis Investigative Site, Valencia

46010

Novartis Investigative Site, Valencia

46014

Novartis Investigative Site, Valencia

47014

Novartis Investigative Site, Meldola

49055

Novartis Investigative Site, Angers

50134

Novartis Investigative Site, Florence

50937

Novartis Investigative Site, Cologne

51056

Novartis Investigative Site, Reims

53111

Novartis Investigative Site, Bonn

54622

Novartis Investigative Site, Thesaloniki

56126

Novartis Investigative Site, Pisa

59100

Novartis Investigative Site, Prato

59494

Novartis Investigative Site, Soest

60389

Novartis Investigative Site, Frankfurt

60540

Edward Hospital Edward Hospital, Naperville

62100

Novartis Investigative Site, Macerata

63011

Novartis Investigative Site, Clermont-Ferrand

63021

Mercy Medical Research Institute SC, Manchester

67100

Novartis Investigative Site, L’Aquila

68165

Novartis Investigative Site, Mannheim

69373

Novartis Investigative Site, Lyon

70006

Crescent City Research Consortium, LLC SC, Metairie

70115

Lsu Health Sciences Center/ Lsu School of Medicine Lsu, New Orleans

70121

John Ochsner Heart and Vascular Institute Clinical Trials Ochsner 2, New Orleans

70124

Novartis Investigative Site, Bari

72076

Novartis Investigative Site, Tübingen

72100

Novartis Investigative Site, Brindisi

72703

Highlands Oncology Group, Fayetteville

73100

Novartis Investigative Site, Lecce

75231

Texas Oncology PA Dallas Presbyterian Hospital SC, Dallas

Novartis Investigative Site, Paris

75246

Texas Oncology Texas Oncology - Sammons, Dallas

75251

Texas Oncology P A SC-Austin, Dallas

Texas Oncology P A Texas Oncology - Fort Worth (3, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

75702

US Oncology, P.A., Tyler

76038

Novartis Investigative Site, Rouen

76135

Novartis Investigative Site, Karlsruhe

77030

The Methodist Hospital Cancer Center, Houston

79905

Texas Tech University Health Science Center Dept of Texas Tech, El Paso

80020

Novartis Investigative Site, Frattamaggiore

80218

Rocky Mountain Cancer Centers SC, Denver

80637

Novartis Investigative Site, München

81377

Novartis Investigative Site, München

82100

Novartis Investigative Site, Benevento

84131

Novartis Investigative Site, Salerno

85224

Ironwood Cancer and Research Centers SC, Chandler

87000

Novartis Investigative Site, Limoges

88214

Novartis Investigative Site, Ravensburg

89081

Novartis Investigative Site, Ulm

89124

Novartis Investigative Site, Reggio Calabria

90017

Los Angeles Hematology/Oncology Medical Group Onc Dept., Los Angeles

90048

Cedars Sinai Medical Center SC-5, Los Angeles

90095

University of California at Los Angeles UCLA SC, Los Angeles

91054

Novartis Investigative Site, Erlangen

92210

Novartis Investigative Site, Saint-Cloud

92708

Compassionate Cancer Care Medical Group CCCMG, Fountain Valley

93940

Pacific Cancer Care, Monterey

95100

Novartis Investigative Site, Catania

96817

Moanalua Medical Center. Attn: Oncology Dept, Honolulu

97210

Northwest Cancer Specialists Compass Oncology -BKM, Portland

97239

Oregon Health and Science University SC-5, Portland

98158

Novartis Investigative Site, Messina

98405

Northwest Medical Specialties, Tacoma

99974

Novartis Investigative Site, Mühlhausen

166830

Novartis Investigative Site, El Achrafiyé

70122-2822

LSU Health Sciences Center Feist-Weiller Cancer Center, New Orleans

07962

Morristown Memorial Hospital Morristown Mem, Morristown

08043

CINJ at Cooper University Hospital Dept of Onc, Voorhees Township

C1050AAK

Novartis Investigative Site, CABA

S2000KZE

Novartis Investigative Site, Rosario

T4000IAK

Novartis Investigative Site, San Miguel de Tucumán

A-1090

Novartis Investigative Site, Vienna

H2W 1T8

Novartis Investigative Site, Montreal

H3A 1A1

Novartis Investigative Site, Montreal

Unknown

Novartis Investigative Site, Bogotá

Novartis Investigative Site, Montería

Novartis Investigative Site, Beirut

FIN-33521

Novartis Investigative Site, Tampere

06189

Novartis Investigative Site, Nice

01307

Novartis Investigative Site, Dresden

711 10

Novartis Investigative Site, Heraklion Crete

151 23

Novartis Investigative Site, Athens

411 10

Novartis Investigative Site, Larissa

265 04

Novartis Investigative Site, Patra - RIO

GR-115 22

Novartis Investigative Site, Athens

H-1122

Novartis Investigative Site, Budapest

H-6720

Novartis Investigative Site, Szeged

H-5000

Novartis Investigative Site, Szolnok

09042

Novartis Investigative Site, Monserrato

03039

Novartis Investigative Site, Sora

00128

Novartis Investigative Site, Roma

00168

Novartis Investigative Site, Roma

07100

Novartis Investigative Site, Sassari

4819 EV

Novartis Investigative Site, Breda

NL 2625 AD

Novartis Investigative Site, Delft

7416 SE

Novartis Investigative Site, Deventer

2134 TM

Novartis Investigative Site, Hoofddorp

2300 RC

Novartis Investigative Site, Leiden

6162 BG

Novartis Investigative Site, Sittard-Geleen

8025 AB

Novartis Investigative Site, Zwolle

NO 0450

Novartis Investigative Site, Oslo

03080

Novartis Investigative Site, Seoul

05505

Novartis Investigative Site, Seoul

03722

Novartis Investigative Site, Seoul

03203

Novartis Investigative Site, Elche

07120

Novartis Investigative Site, Palma de Mallorca

08916

Novartis Investigative Site, Badalona

08003

Novartis Investigative Site, Barcelona

08035

Novartis Investigative Site, Barcelona

08036

Novartis Investigative Site, Barcelona

08041

Novartis Investigative Site, Barcelona

SE-391 85

Novartis Investigative Site, Kalmar

SE-171 76

Novartis Investigative Site, Stockholm

751 85

Novartis Investigative Site, Uppsala

BB2 3HH

Novartis Investigative Site, Blackburn

IP4 5PD

Novartis Investigative Site, Ipswich

EH4 2XU

Novartis Investigative Site, Edinburgh

SM2 5PT

Novartis Investigative Site, London

SW3 6JJ

Novartis Investigative Site, London

M20 2BX

Novartis Investigative Site, Manchester

NG5 1PB

Novartis Investigative Site, Nottingham

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY