209
Participants
Start Date
July 31, 2012
Primary Completion Date
October 31, 2014
Study Completion Date
December 31, 2014
Continuous Positive Airway Pressure device (Resmed, Swift, Mirage)
Continuous Positive Airway Pressure device (Resmed, Swift, Mirage): Participants will be randomized to one of three pre-set CPAP pressures: less than 1 cm water (H₂O), 5 cm H₂O or 10 cm H₂O. They will be instructed to use the CPAP device every night for 12 weeks. Methacholine airways reactivity will be measured at the end of these 12 weeks and again after a 2-week washout period, 14 weeks after randomization.
St. Vincent Hospital and Health Care Center, Inc, Indianapolis
University of Arizona, Tucson
University of California, San Diego, San Diego
National Jewish Health, Denver
Nemours Children's Clinic, Jacksonville
University of Miami/ University of South Florida, Miami
Illinois Consortium, Chicago
Louisiana State University Health Sciences Center, The Ernest N. Morial Asthma, Allergy and Respiratory Disease Center, New Orleans
University of Missouri, Kansas City School of Medicine, Kansas City
Washington University/ St. Louis University, St Louis
Hofstra University School of Medicine, Hempstead
Columbia University - New York University Consortium, New York
New York Medical College, Valhalla
Duke University Medical Center, Durham
Ohio State University Medical Center/ Columbus Children's Hospital, Columbus
Baylor College of Medicine, Houston
Northern New England Consortium, Colchester
University of Virginia, Charlottesville
National Heart, Lung, and Blood Institute (NHLBI)
NIH
American Lung Association Asthma Clinical Research Centers
OTHER