Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

143

Participants

Timeline

Start Date

December 6, 2012

Primary Completion Date

December 30, 2019

Study Completion Date

May 20, 2022

Conditions
HER2-Positive Breast CarcinomaInvasive Breast CarcinomaMetastatic Malignant Neoplasm in the BrainRecurrent Breast CarcinomaStage IV Breast Cancer AJCC v6 and v7
Interventions
OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Lapatinib Ditosylate

Given PO

RADIATION

Stereotactic Radiosurgery

Undergo SRS

RADIATION

Whole-Brain Radiotherapy

Undergo WBRT

Trial Locations (302)

10029

Mount Sinai Hospital, New York

10467

Montefiore Medical Center - Moses Campus, The Bronx

11215

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn

13057

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse

14263

Roswell Park Cancer Institute, Buffalo

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18301

Pocono Medical Center, East Stroudsburg

19001

Jefferson Abington Hospital, Abington

19107

Thomas Jefferson University Hospital, Philadelphia

19611

Reading Hospital, West Reading

19713

Christiana Gynecologic Oncology LLC, Newark

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

Beebe Medical Center, Lewes

19971

Beebe Health Campus, Rehoboth Beach

19973

TidalHealth Nanticoke / Allen Cancer Center, Seaford

21204

Greater Baltimore Medical Center, Baltimore

22401

Fredericksburg Oncology Inc, Fredericksburg

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

26003

Wheeling Hospital/Schiffler Cancer Center, Wheeling

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

28677

Iredell Memorial Hospital, Statesville

28792

AdventHealth Hendersonville, Hendersonville

29303

Spartanburg Medical Center, Spartanburg

29341

Gibbs Cancer Center-Gaffney, Gaffney

29425

Medical University of South Carolina, Charleston

29621

AnMed Health Cancer Center, Anderson

29651

Gibbs Cancer Center-Pelham, Greer

30041

Northside Hospital-Forsyth, Cumming

30214

Piedmont Fayette Hospital, Fayetteville

30309

Piedmont Hospital, Atlanta

30342

Northside Hospital, Atlanta

30501

Northeast Georgia Medical Center-Gainesville, Gainesville

31405

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33176

Miami Cancer Institute, Miami

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

University of Alabama at Birmingham Cancer Center, Birmingham

35243

The Kirklin Clinic at Acton Road, Birmingham

36688

University of South Alabama Mitchell Cancer Institute, Mobile

39216

University of Mississippi Medical Center, Jackson

39581

Singing River Hospital, Pascagoula

40202

Norton Hospital Pavilion and Medical Campus, Louisville

40207

Norton Suburban Hospital and Medical Campus, Louisville

42601

Keimyung University-Dongsan Medical Center, Dalseo-gu

43210

Ohio State University Comprehensive Cancer Center, Columbus

43402

Toledo Clinic Cancer Centers-Bowling Green, Bowling Green

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee

43560

ProMedica Flower Hospital, Sylvania

43567

Fulton County Health Center, Wauseon

43608

Saint Vincent Mercy Medical Center, Toledo

43614

University of Toledo, Toledo

43616

Saint Charles Hospital, Oregon

Toledo Clinic Cancer Centers-Oregon, Oregon

43617

Toledo Community Hospital Oncology Program CCOP, Toledo

43623

Mercy Health - Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

44024

Geauga Hospital, Chardon

44035

Mercy Cancer Center-Elyria, Elyria

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

Cleveland Clinic Cancer Center Beachwood, Beachwood

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44129

University Hospitals Parma Medical Center, Parma

44130

UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights

44131

Cleveland Clinic Cancer Center Independence, Independence

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44145

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44203

Summa Health System - Barberton Campus, Barberton

44256

Summa Health Medina Medical Center, Medina

44266

University Hospitals Portage Medical Center, Ravenna

44304

Summa Health System - Akron Campus, Akron

44307

Cleveland Clinic Akron General, Akron

44460

UH Seidman Cancer Center at Salem Regional Medical Center, Salem

44601

Radiation Oncology Center, Alliance

44691

Cancer Treatment Center, Wooster

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

44708

Cleveland Clinic Mercy Hospital, Canton

44870

North Coast Cancer Care, Sandusky

44883

Mercy Hospital of Tiffin, Tiffin

44906

Cleveland Clinic Cancer Center Mansfield, Mansfield

45005

Dayton Physicians LLC-Atrium, Franklin

45236

Oncology Hematology Care Inc-Kenwood, Cincinnati

45331

Dayton Physicians LLC-Wayne, Greenville

Wayne Hospital, Greenville

45373

Dayton Physicians LLC-Upper Valley, Troy

Upper Valley Medical Center, Troy

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Dayton Physician LLC-Miami Valley Hospital North, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Dayton Physicians LLC-Miami Valley South, Centerville

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

45505

Springfield Regional Medical Center, Springfield

45804

Lima Memorial Hospital, Lima

45840

Armes Family Cancer Center, Findlay

Blanchard Valley Hospital, Findlay

Orion Cancer Care, Findlay

46350

IU Health La Porte Hospital, La Porte

46391

Michiana Hematology Oncology PC-Westville, Westville

46514

Michiana Hematology Oncology PC-Elkhart, Elkhart

46515

Elkhart General Hospital, Elkhart

46545

Memorial Regional Cancer Center Day Road, Mishawaka

Michiana Hematology Oncology PC-Mishawaka, Mishawaka

Saint Joseph Regional Medical Center-Mishawaka, Mishawaka

46563

Michiana Hematology Oncology PC-Plymouth, Plymouth

46601

Memorial Hospital of South Bend, South Bend

Michiana Hematology Oncology PC-South Bend, South Bend

46617

South Bend Clinic, South Bend

46804

Radiation Oncology Associates PC, Fort Wayne

46805

Parkview Hospital Randallia, Fort Wayne

46845

Parkview Regional Medical Center, Fort Wayne

46904

Community Howard Regional Health, Kokomo

47374

Reid Health, Richmond

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48060

Lake Huron Medical Center, Port Huron

48093

Saint John Macomb-Oakland Hospital, Warren

48106

Saint Joseph Mercy Hospital, Ann Arbor

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

Saint Joseph Mercy Brighton, Brighton

48118

Saint Joseph Mercy Chelsea, Chelsea

48124

Beaumont Hospital - Dearborn, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48162

Mercy Memorial Hospital, Monroe

Toledo Clinic Cancer Centers-Monroe, Monroe

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48188

Saint Joseph Mercy Canton, Canton

48202

Henry Ford Hospital, Detroit

48236

Ascension Saint John Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48341

21st Century Oncology-Pontiac, Pontiac

Saint Joseph Mercy Oakland, Pontiac

48503

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48912

Sparrow Hospital, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49048

Borgess Medical Center, Kalamazoo

49085

Lakeland Medical Center Saint Joseph, Saint Joseph

Marie Yeager Cancer Center, Saint Joseph

49120

Lakeland Hospital Niles, Niles

49201

Allegiance Health, Jackson

49221

Bixby Medical Center, Adrian

Hickman Cancer Center, Adrian

49307

Spectrum Health Big Rapids Hospital, Big Rapids

49444

Mercy Health Mercy Campus, Muskegon

49503

Mercy Health Saint Mary's, Grand Rapids

Spectrum Health at Butterworth Campus, Grand Rapids

49519

Metro Health Hospital, Wyoming

49684

Munson Medical Center, Traverse City

49801

Green Bay Oncology - Iron Mountain, Iron Mountain

49829

Green Bay Oncology - Escanaba, Escanaba

52402

Saint Luke's Hospital, Cedar Rapids

53038

UW Cancer Center Johnson Creek, Johnson Creek

53097

Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon

53211

Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center, Madison

54017

Cancer Center of Western Wisconsin, New Richmond

54143

Bay Area Medical Center, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54221

Holy Family Memorial Hospital, Manitowoc

54235

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55337

Fairview Ridges Hospital, Burnsville

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

56201

Rice Memorial Hospital, Willmar

60504

Rush - Copley Medical Center, Aurora

60612

John H Stroger Jr Hospital of Cook County, Chicago

60657

UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital, Chicago

61801

Carle Cancer Center, Urbana

61832

Carle on Vermilion, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

62864

Good Samaritan Regional Health Center, Mount Vernon

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

Saint Louis-Cape Girardeau CCOP, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

Saint Francis Medical Center, Cape Girardeau

64057

Centerpoint Medical Center LLC, Independence

64068

Liberty Radiation Oncology Center, Liberty

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64111

Saint Luke's Hospital of Kansas City, Kansas City

64116

North Kansas City Hospital, Kansas City

64118

Heartland Hematology and Oncology Associates Incorporated, Kansas City

64132

Research Medical Center, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

64507

Saint Joseph Oncology Inc, Saint Joseph

64804

Mercy Hospital Joplin, Joplin

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66209

Menorah Medical Center, Overland Park

66213

Saint Luke's South Hospital, Overland Park

66219

Kansas Institute of Medicine Cancer and Blood Center, Lenexa

Minimally Invasive Surgery Hospital, Lenexa

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

70121

Ochsner Medical Center Jefferson, New Orleans

74136

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa

74146

Warren Clinic Oncology-Tulsa, Tulsa

78229

University of Texas Health Science Center at San Antonio, San Antonio

79410

Covenant Medical Center-Lakeside, Lubbock

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83642

Idaho Urologic Institute-Meridian, Meridian

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

85013

Saint Joseph's Hospital and Medical Center, Phoenix

85719

Banner University Medical Center - Tucson, Tucson

87102

University of New Mexico Cancer Center, Albuquerque

88011

Memorial Medical Center - Las Cruces, Las Cruces

89502

Renown Regional Medical Center, Reno

94010

Mills-Peninsula Medical Center, Burlingame

94040

Palo Alto Medical Foundation-Camino Division, Mountain View

Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

California Pacific Medical Center-Pacific Campus, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94304

Stanford Cancer Institute Palo Alto, Palo Alto

94568

Epic Care-Dublin, Dublin

94589

Sutter Solano Medical Center/Cancer Center, Vallejo

94597

Epic Care Cyberknife Center, Walnut Creek

94608

Bay Area Breast Surgeons Inc, Emeryville

Epic Care Partners in Cancer Care, Emeryville

94609

Alta Bates Summit Medical Center - Summit Campus, Oakland

Bay Area Tumor Institute, Oakland

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

94945

Sutter Cancer Research Consortium, Novato

95065

Palo Alto Medical Foundation-Santa Cruz, Santa Cruz

95355

Memorial Medical Center, Modesto

95403

Sutter Pacific Medical Foundation, Santa Rosa

95602

Sutter Auburn Faith Hospital, Auburn

95603

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn

95608

Mercy San Juan Medical Center, Carmichael

95616

Sutter Davis Hospital, Davis

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

Sutter Roseville Medical Center, Roseville

95682

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park

95687

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville

95816

Sutter Medical Center Sacramento, Sacramento

95819

Mercy General Hospital Radiation Oncology Center, Sacramento

97030

Legacy Mount Hood Medical Center, Gresham

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

98686

Legacy Salmon Creek Hospital, Vancouver

94553-3156

Contra Costa Regional Medical Center, Martinez

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06050

The Hospital of Central Connecticut, New Britain

46514-2098

Elkhart Clinic, Elkhart

02118

Boston Medical Center, Boston

03103

Elliot Hospital, Manchester

07039

Saint Barnabas Medical Center, Livingston

08060

Virtua Memorial, Mount Holly

08043

Virtua Voorhees, Voorhees Township

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

05602

Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners

05401

University of Vermont Medical Center, Burlington

05405

University of Vermont and State Agricultural College, Burlington

54301-3526

Green Bay Oncology at Saint Vincent Hospital, Green Bay

54235-1495

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

H3T 1E2

Jewish General Hospital, Montreal

410-769

National Cancer Center-Korea, Goyang-si

519-763

Chonnam National University Hwasun Hospital, Hwasun-gun

135-710

Samsung Medical Center, Seoul

463-707

Seoul National University Bundang Hospital, Seongnam

06273

Gangnam Severance Hospital, Seoul

110-744

Seoul National University Hospital, Seoul

120-752

Yonsei University Health System-Severance Hospital, Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH