Phase III Study of BKM120/Placebo With Fulvestrant in Postmenopausal Patients With Hormone Receptor Positive HER2-negative Locally Advanced or Metastatic Breast Cancer Refractory to Aromatase Inhibitor

PHASE3CompletedINTERVENTIONAL
Enrollment

1,147

Participants

Timeline

Start Date

August 7, 2012

Primary Completion Date

April 29, 2015

Study Completion Date

April 19, 2019

Conditions
Breast Cancer
Interventions
DRUG

Fulvestrant

Intramuscular fulvestrant 500 mg (Day 1 and Day 15 of Cycle 1 and Day 1 of every cycle thereafter)

DRUG

BKM120

BKM120 100 mg once daily

DRUG

BKM120 matching placebo

BKM120 matching placebo, once daily

Trial Locations (268)

34

Novartis Investigative Site, Surquillo

112

Novartis Investigative Site, Taipei

833

Novartis Investigative Site, Kaohsiung City

1000

Novartis Investigative Site, Brussels

1090

Novartis Investigative Site, Jette

1211

Novartis Investigative Site, Geneva

2060

Novartis Investigative Site, Sydney

2193

Novartis Investigative Site, Parktown

2196

Novartis Investigative Site, Johannesburg

2500

Novartis Investigative Site, Woollongong

2610

Novartis Investigative Site, Wilrijk

3000

Novartis Investigative Site, Melbourne

Novartis Investigative Site, Leuven

3168

Novartis Investigative Site, Clayton

3526

Novartis Investigative Site, Miskolc

4000

Novartis Investigative Site, Liège

4010

Novartis Investigative Site, Linz

4032

Novartis Investigative Site, Debrecen

4101

Novartis Investigative Site, South Brisbane

5000

Novartis Investigative Site, Namur

5020

Novartis Investigative Site, Salzburg

6000

Novartis Investigative Site, Charleroi

6009

Novartis Investigative Site, Nedlands

6150

Novartis Investigative Site, Murdoch

6500

Novartis Investigative Site, Bellinzona

8038

Novartis Investigative Site, Zurich

8500

Novartis Investigative Site, Rio Negro

10017

Memorial Sloan Kettering Dept Onc, New York

10048

Novartis Investigative Site, Taipei

10126

Novartis Investigative Site, Torino

10330

Novartis Investigative Site, Bangkok

10400

Novartis Investigative Site, Bangkok

10700

Novartis Investigative Site, Bangkok

11042

Clinical Research Alliance SC-2, Lake Success

12100

Novartis Investigative Site, Cuneo

14004

Novartis Investigative Site, Córdoba

14021

Novartis Investigative Site, Caen

14642

University of Rochester Medical Center Univ Rochester, Rochester

18015

St. Luke's Hospital and Health Network St Luke's (2), Bethlehem

20089

Novartis Investigative Site, Rozzano

20122

Novartis Investigative Site, Milan

20133

Novartis Investigative Site, Milan

20141

Novartis Investigative Site, Milan

20162

Novartis Investigative Site, Milan

20249

Novartis Investigative Site, Hamburg

20850

Maryland Oncology Hematology, P.A. SC, Rockville

21034

Novartis Investigative Site, Dijon

21202

Mercy Medical Center Mercy Medical SC, Baltimore

21231

Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Med Sidney/John Hopkins, Baltimore

21701

Frederick Memorial Hospital Fred. Mem. Hosp., Frederick

23007

Novartis Investigative Site, Jaén

23563

Novartis Investigative Site, Lübeck

24014

Oncology Hematology Associates of Southeast Virginia Salem VA Branch, Roanoke

24105

Novartis Investigative Site, Kiel

25030

Novartis Investigative Site, Besançon

26100

Novartis Investigative Site, Cremona

26506

West Virginia University/ Mary Babb Randolph Cancer Center Dept of Oncology, Morgantown

27157

Wake Forest University Health Sciences, Winston-Salem

28009

Novartis Investigative Site, Madrid

28033

Novartis Investigative Site, Madrid

28040

Novartis Investigative Site, Madrid

28046

Novartis Investigative Site, Madrid

28050

Novartis Investigative Site, Madrid

28203

Levine Cancer Institute Levine Cancer Institute, Charlotte

28222

Novartis Investigative Site, Madrid

28702

Novartis Investigative Site, San Sebastián de los Reyes

29010

Novartis Investigative Site, Málaga

29414

Charleston Hematology Oncology Association PA, Charleston

30033

Georgia Cancer Specialists SC, Decatur

30035

Novartis Investigative Site, Mirano

30120

Novartis Investigative Site, El Palmar

30177

Novartis Investigative Site, Hanover

31059

Novartis Investigative Site, Toulouse

32258

Cancer Specialists of North Florida SC - F2302, Jacksonville

32806

MD Anderson Cancer Center - Orlando MD Orlando, Orlando

33006

Novartis Investigative Site, Oviedo

33021

Memorial Regional Cancer Center MRCC, Hollywood

33076

Novartis Investigative Site, Bordeaux

33081

Novartis Investigative Site, Aviano

33136

University of Miami Univ Miami 2, Miami

34298

Novartis Investigative Site, Montpellier

35016

Novartis Investigative Site, Las Palmas de Gran Canarias

36688

University of South Alabama / Mitchell Cancer Institute Deptof Mitchell Cancer Inst(2), Mobile

37232

Vanderbilt University Medical Center Vanderbilt - Thompson Ln, Nashville

37909

Tennessee Cancer Specialists, Knoxville

38801

Hematology and Oncology Association at Bridgepoint Hem Onc Bridgepoint, Tupelo

39108

Novartis Investigative Site, Magdeburg

40138

Novartis Investigative Site, Bologna

40447

Novartis Investigative Site, Taichung

41009

Novartis Investigative Site, Seville

41013

Novartis Investigative Site, Seville

41014

Novartis Investigative Site, Seville

42270

Novartis Investigative Site, Saint Priest En Jarez

42551

Novartis Investigative Site, Velbert

43007

Novartis Investigative Site, Tarragona

44805

Novartis Investigative Site, Saint-Herblain Cédex

45071

Novartis Investigative Site, Toledo

45147

Novartis Investigative Site, Essen

45657

Novartis Investigative Site, Recklinghausen

46009

Novartis Investigative Site, Valencia

46010

Novartis Investigative Site, Valencia

46026

Novartis Investigative Site, Valencia

47014

Novartis Investigative Site, Meldola

47900

Novartis Investigative Site, Rimini

49007

West Michigan Cancer Center Dept of Oncology, Kalamazoo

49055

Novartis Investigative Site, Angers

49100

Novartis Investigative Site, Petah Tikva

50009

Novartis Investigative Site, Zaragoza

50134

Novartis Investigative Site, Florence

52621

Novartis Investigative Site, Ramat Gan

53717

Dean Health System Dean Hematology Oncology, Madison

54313

Cancer TEAM Bellin Health Belin Health, Green Bay

54645

Novartis Investigative Site, Thessaloniki

55041

Novartis Investigative Site, Lido di Camaiore

55131

Novartis Investigative Site, Mainz

56126

Novartis Investigative Site, Pisa

59020

Novartis Investigative Site, Lille

60134

Cadence Health, Geneva

60201

North Shore University Health System, Evanston

62100

Novartis Investigative Site, Macerata

63011

Novartis Investigative Site, Clermont-Ferrand

63110

Washington University School of Medicine Regulatory, St Louis

63225

Novartis Investigative Site, Langen

65653

Novartis Investigative Site, Brno

66113

Novartis Investigative Site, Saarbrücken

67085

Novartis Investigative Site, Strasbourg

68165

Novartis Investigative Site, Mannheim

69120

Novartis Investigative Site, Heidelberg

72015

Novartis Investigative Site, Le Mans

72703

Highlands Oncology Group, Fayetteville

75010

Novartis Investigative Site, Paris

75231

Novartis Investigative Site, Paris

75251

Texas Oncology P A Midtown, Dallas

Texas Oncology P A TX Onc - Bedford, Dallas

Texas Oncology P A TX Onc - Med City Dallas, Dallas

Texas Oncology P A TX Onc - Southwest, Dallas

76038

Novartis Investigative Site, Rouen

77024

Oncology Consultants Oncology Consultants, P.A., Houston

78229

Cancer Therapy and Research Center UT Health Science Center Institute for Drug Development, San Antonio

80131

Novartis Investigative Site, Napoli

80638

Novartis Investigative Site, München

80756

Novartis Investigative Site, Kaohsiung City

83310

Novartis Investigative Site, Bratislava

84082

Novartis Investigative Site, Avignon

84106

Utah Cancer Specialists Dept.of Utah Cancer Spec. (3), Salt Lake City

88100

Novartis Investigative Site, Catanzaro

90017

Los Angeles Hematology/Oncology Medical Group LA Cancer Network, Los Angeles

90053

USC Kenneth Norris Comprehensive Cancer Center Dept.ofNorrisCompCancerCtr (3), Los Angeles

90095

University of California at Los Angeles Dept. of UCLA, Los Angeles

91007

Shapiro and Stafford and Yee and Polanski Study Coordinator, Arcadia

91120

Novartis Investigative Site, Jerusalem

91355

Granada Hills Cancer Center, Valencia

92835

St. Jude Heritage Medical Group Virginia Crosson Cancer Center, Fullerton

93030

Ventura County Hematology and Oncology PMK Medical Group, Oxnard

93105

Santa Barbara Hematolgy Oncology Medical Group, Santa Barbara

93401

Coastal Integrative Cancer Care, San Luis Obispo

93454

Central Coast Medical Oncology Corporation, Santa Maria

93720

Cancer Care Associates Dept.ofCancerCareAssoc., Fresno

94503

St Joseph Heritage Healthcare Dept. of RRMG (4), Santa Rosa

94800

Novartis Investigative Site, Villejuif

97080

Novartis Investigative Site, Würzburg

97210

Northwest Cancer Specialists Portland Loc, Portland

99336

Kadlec Clinic Hematology and Oncology Kadlec Clinic Hematology & Onc, Kennewick

99974

Novartis Investigative Site, Mühlhausen

100039

Novartis Investigative Site, Beijing

110042

Novartis Investigative Site, Shengyang

115478

Novartis Investigative Site, Moscow

115998

Novartis Investigative Site, Moscow

150081

Novartis Investigative Site, Harbin

169610

Novartis Investigative Site, Singapore

197022

Novartis Investigative Site, Saint Petersburg

197758

Novartis Investigative Site, Saint Petersburg

200025

Novartis Investigative Site, Shanghai

200032

Novartis Investigative Site, Shanghai

210009

Novartis Investigative Site, Nanjing

310022

Novartis Investigative Site, Hangzhou

410013

Novartis Investigative Site, Changsha

443380

Novartis Investigative Site, Suwon

510060

Novartis Investigative Site, Guangzhou

603081

Novartis Investigative Site, Nizhny Novgorod

610041

Novartis Investigative Site, Chengdu

3525408

Novartis Investigative Site, Haifa

6423906

Novartis Investigative Site, Tel Aviv

Unknown

Arizona Oncology Associates Dept of Oncology, Phoenix

Kaiser Permanente Northwest Kaiser, Denver

Rocky Mountain Cancer Centers RMCC, Greenwood Village

Cancer Care and Hematology Specialists of Chicagoland Niles, Multiple Locations

Novartis Investigative Site, Sorocaba

Novartis Investigative Site, Krakow

92093-0658

University of California San Diego - Moores Cancer Center UCSD 3, La Jolla

67214-3728

Cancer Center of Kansas CCK, Wichita

02114

Massachusetts General Hospital SC, Boston

08724

Hackensack Meridian Health, Brick

07652

The Valley Hospital / Luckow Pavillion, Paramus

44106-5000

Case Western Reserve SC, Cleveland

53792-6164

University of Wisconsin / Paul P. Carbone Comp Cancer Center Univ Wisc 3, Madison

C1050AAK

Novartis Investigative Site, CABA

B7600CTO

Novartis Investigative Site, Mar del Plata

T4000IAK

Novartis Investigative Site, San Miguel de Tucumán

A-1090

Novartis Investigative Site, Vienna

30150-270

Novartis Investigative Site, Belo Horizonte

81520-060

Novartis Investigative Site, Curitiba

59075 740

Novartis Investigative Site, Natal

98700-000

Novartis Investigative Site, Ijuí

14784 400

Novartis Investigative Site, Barretos

01246 000

Novartis Investigative Site, São Paulo

T2N 4N2

Novartis Investigative Site, Calgary

T6G 1Z2

Novartis Investigative Site, Edmonton

V1Y 5L3

Novartis Investigative Site, Kelowna

V5Z 4E6

Novartis Investigative Site, Vancouver

B3H 1V7

Novartis Investigative Site, Halifax

N1R 3G2

Novartis Investigative Site, Cambridge

N6A 4L6

Novartis Investigative Site, London

J7Y 2P9

Novartis Investigative Site, Newmarket

K1H 8L6

Novartis Investigative Site, Ottawa

M4N 3M5

Novartis Investigative Site, Toronto

M5G 2M9

Novartis Investigative Site, Toronto

H7M 3L9

Novartis Investigative Site, Laval

H2L 4M1

Novartis Investigative Site, Montreal

G1S 4L8

Novartis Investigative Site, Québec

S4T 7T1

Novartis Investigative Site, Regina

625 00

Novartis Investigative Site, Brno Bohunice

775 20

Novartis Investigative Site, Olomouc

06189

Novartis Investigative Site, Nice

711 10

Novartis Investigative Site, Heraklion Crete

115 28

Novartis Investigative Site, Athens

265 00

Novartis Investigative Site, Pátrai

H 1122

Novartis Investigative Site, Budapest

H-5000

Novartis Investigative Site, Szolnok

00128

Novartis Investigative Site, Roma

00161

Novartis Investigative Site, Roma

00189

Novartis Investigative Site, Roma

464 8681

Novartis Investigative Site, Nagoya

277 8577

Novartis Investigative Site, Kashiwa

811-1395

Novartis Investigative Site, Fukuoka

371 8511

Novartis Investigative Site, Maebashi

003-0804

Novartis Investigative Site, Sapporo

259-1193

Novartis Investigative Site, Isehara

241-8515

Novartis Investigative Site, Yokohama

860-8556

Novartis Investigative Site, Kumamoto

606 8507

Novartis Investigative Site, Sakyo Ku

540-0006

Novartis Investigative Site, Osaka

541-8567

Novartis Investigative Site, Osaka

565 0871

Novartis Investigative Site, Suita

135 8550

Novartis Investigative Site, Koto Ku

6500 HB

Novartis Investigative Site, Nijmegen

10-513

Novartis Investigative Site, Olsztyn

02-776

Novartis Investigative Site, Warsaw

041 91

Novartis Investigative Site, Košice

06591

Novartis Investigative Site, Seoul

03080

Novartis Investigative Site, Seoul

03722

Novartis Investigative Site, Seoul

06351

Novartis Investigative Site, Seoul

03203

Novartis Investigative Site, Elche

08003

Novartis Investigative Site, Barcelona

08024

Novartis Investigative Site, Barcelona

08035

Novartis Investigative Site, Barcelona

08036

Novartis Investigative Site, Barcelona

08041

Novartis Investigative Site, Barcelona

TR1 3LJ

Novartis Investigative Site, Truro

BH7 7DW

Novartis Investigative Site, Bournemouth

DE22 3NE

Novartis Investigative Site, Derby

LE1 5WW

Novartis Investigative Site, Leicester

L7 8XP

Novartis Investigative Site, Liverpool

SE1 9RT

Novartis Investigative Site, London

WC1E 6HX

Novartis Investigative Site, London

M20 2BX

Novartis Investigative Site, Manchester

OX3 7LJ

Novartis Investigative Site, Oxford

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY