Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

137

Participants

Timeline

Start Date

June 4, 2012

Primary Completion Date

October 2, 2015

Study Completion Date

May 20, 2022

Conditions
Giant Cell GlioblastomaGlioblastomaGliosarcomaOligodendrogliomaRecurrent Brain NeoplasmRecurrent Glioblastoma
Interventions
BIOLOGICAL

Bevacizumab

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Pharmacological Study

Correlative studies

OTHER

Placebo Administration

Given IV

BIOLOGICAL

Trebananib

Given IV

Trial Locations (244)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10467

Montefiore Medical Center - Moses Campus, The Bronx

12206

New York Oncology Hematology PC - Albany, Albany

12208

New York Oncology Hematology PC - Albany Medical Center, Albany

13021

Hematology Oncology Associates of Central New York-Auburn, Auburn

13057

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse

13088

Hematology Oncology Associates of Central New York-Liverpool, Liverpool

13215

Hematology Oncology Associates of Central New York-Onondaga Hill, Syracuse

13440

Hematology Oncology Associates of Central New York-Rome, Rome

15009

UPMC-Heritage Valley Health System Beaver, Beaver

15065

UPMC Cancer Center-Natrona Heights, Natrona Heights

15132

UPMC Cancer Center at UPMC McKeesport, McKeesport

15213

UPMC-Presbyterian Hospital, Pittsburgh

15215

UPMC-Saint Margaret, Pittsburgh

15232

UPMC-Shadyside Hospital, Pittsburgh

15236

UPMC Jefferson Regional Radiation Oncology, Pittsburgh

15237

UPMC-Passavant Hospital, Pittsburgh

15243

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15301

UPMC Washington Hospital Radiation Oncology, Washington

15401

UPMC Uniontown Hospital Radiation Oncology, Uniontown

15601

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

15901

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown

16105

UPMC Jameson, New Castle

16121

UPMC Cancer Center at UPMC Horizon, Farrell

16346

UPMC Cancer Center at UPMC Northwest, Seneca

17325

Adams Cancer Center, Gettysburg

17331

Cherry Tree Cancer Center, Hanover

17403

WellSpan Health-York Hospital, York

17602

Lancaster General Hospital, Lancaster

18015

Saint Luke's University Hospital-Bethlehem Campus, Bethlehem

19010

Bryn Mawr Hospital, Bryn Mawr

19096

Lankenau Medical Center, Wynnewood

Main Line Health NCORP, Wynnewood

19107

Thomas Jefferson University Hospital, Philadelphia

19301

Paoli Memorial Hospital, Paoli

19611

Reading Hospital, West Reading

27104

Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem

28139

Rutherford Hospital, Rutherfordton

28792

AdventHealth Hendersonville, Hendersonville

28801

Mission Hospital, Asheville

Mountain Radiation Oncology PA, Asheville

28803

AdventHealth Infusion Center Asheville, Asheville

28806

Messino Cancer Centers, Asheville

29303

Spartanburg Medical Center, Spartanburg

29621

AnMed Health Cancer Center, Anderson

29651

Gibbs Cancer Center-Pelham, Greer

30214

Piedmont Fayette Hospital, Fayetteville

30309

Piedmont Hospital, Atlanta

30501

Northeast Georgia Medical Center-Gainesville, Gainesville

33316

Broward Health Medical Center, Fort Lauderdale

39216

University of Mississippi Medical Center, Jackson

39581

Singing River Hospital, Pascagoula

40536

University of Kentucky/Markey Cancer Center, Lexington

43015

Delaware Health Center-Grady Cancer Center, Delaware

Delaware Radiation Oncology, Delaware

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

Newark Radiation Oncology, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

Lancaster Radiation Oncology, Lancaster

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

43215

Columbus NCI Community Oncology Research Program, Columbus

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44203

Summa Health System - Barberton Campus, Barberton

44256

Summa Health Medina Medical Center, Medina

44266

University Hospitals Portage Medical Center, Ravenna

44304

Summa Health System - Akron Campus, Akron

44307

Cleveland Clinic Akron General, Akron

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45505

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45714

Strecker Cancer Center-Belpre, Belpre

45750

Marietta Memorial Hospital, Marietta

48060

Lake Huron Medical Center, Port Huron

48073

William Beaumont Hospital-Royal Oak, Royal Oak

48085

William Beaumont Hospital - Troy, Troy

48093

Saint John Macomb-Oakland Hospital, Warren

48106

Michigan Cancer Research Consortium NCORP, Ann Arbor

Saint Joseph Mercy Hospital, Ann Arbor

48124

Beaumont Hospital - Dearborn, Dearborn

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48236

Ascension Saint John Hospital, Detroit

48341

Saint Joseph Mercy Oakland, Pontiac

48503

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48912

Sparrow Hospital, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49048

Borgess Medical Center, Kalamazoo

49801

Green Bay Oncology - Iron Mountain, Iron Mountain

49829

Green Bay Oncology - Escanaba, Escanaba

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53149

ProHealth D N Greenwald Center, Mukwonago

53188

ProHealth Waukesha Memorial Hospital, Waukesha

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center, Madison

54017

Cancer Center of Western Wisconsin, New Richmond

54143

Bay Area Medical Center, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54221

Holy Family Memorial Hospital, Manitowoc

54235

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

56201

Rice Memorial Hospital, Willmar

57701

Rapid City Regional Hospital, Rapid City

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60504

Rush - Copley Medical Center, Aurora

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60560

Rush-Copley Healthcare Center, Yorkville

60611

Northwestern University, Chicago

60612

Rush University Medical Center, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61401

Illinois CancerCare-Galesburg, Galesburg

61554

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61761

Carle Cancer Institute Normal, Normal

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle on Vermilion, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

62526

Heartland Cancer Research NCORP, Decatur

62864

Good Samaritan Regional Health Center, Mount Vernon

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63703

Saint Francis Medical Center, Cape Girardeau

64057

Centerpoint Medical Center LLC, Independence

64068

Liberty Radiation Oncology Center, Liberty

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64111

Saint Luke's Hospital of Kansas City, Kansas City

64116

North Kansas City Hospital, Kansas City

64118

Heartland Hematology and Oncology Associates Incorporated, Kansas City

64132

Research Medical Center, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

64507

Saint Joseph Oncology Inc, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65401

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65804

Cancer Research for the Ozarks NCORP, Springfield

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66208

Kansas City NCI Community Oncology Research Program, Prairie Village

66209

Menorah Medical Center, Overland Park

66213

Saint Luke's South Hospital, Overland Park

68114

Nebraska Methodist Hospital, Omaha

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74136

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

Warren Clinic Oncology-Tulsa, Tulsa

75246

Texas Oncology at Baylor Charles A Sammons Cancer Center, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

75601

Texas Oncology-Longview Cancer Center, Longview

75702

Tyler Cancer Center, Tyler

76022

Texas Oncology Bedford, Bedford

76053

Texas Oncology-Grapevine, Grapevine

76104

Texas Oncology - Fort Worth Cancer Center, Fort Worth

77479

Texas Oncology Cancer Center Sugar Land, Sugar Land

78665

Texas Oncology-Seton Williamson, Round Rock

78681

Texas Oncology - Round Rock Cancer Center, Round Rock

78705

Texas Oncology-Austin Midtown, Austin

78731

Texas Oncology - Central Austin Cancer Center, Austin

78745

Texas Oncology - South Austin Cancer Center, Austin

80524

Poudre Valley Hospital, Fort Collins

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

84003

American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84143

LDS Hospital, Salt Lake City

84321

Logan Regional Hospital, Logan

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center, Provo

84720

Sandra L Maxwell Cancer Center, Cedar City

84770

Saint George Regional Medical Center, St. George

85027

Arizona Oncology-Deer Valley Center, Phoenix

85260

Arizona Oncology Services Foundation, Scottsdale

85704

Arizona Oncology Associates-West Orange Grove, Tucson

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90033

Los Angeles County-USC Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

92868

Saint Joseph Hospital - Orange, Orange

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94010

Mills-Peninsula Medical Center, Burlingame

94115

California Pacific Medical Center-Pacific Campus, San Francisco

94589

Sutter Solano Medical Center/Cancer Center, Vallejo

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

94945

Sutter Cancer Research Consortium, Novato

97015

Clackamas Radiation Oncology Center, Clackamas

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97401

Willamette Valley Cancer Center, Eugene

98664

PeaceHealth Southwest Medical Center, Vancouver

98684

Compass Oncology Vancouver, Vancouver

99202

Cancer Care Northwest - Spokane South, Spokane

99218

Cancer Care Northwest-North Spokane, Spokane

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06050

The Hospital of Central Connecticut, New Britain

06360

Eastern Connecticut Hematology and Oncology Associates, Norwich

William Backus Hospital, Norwich

04074

Maine Medical Center- Scarborough Campus, Scarborough

54301-3526

Green Bay Oncology at Saint Vincent Hospital, Green Bay

54235-1495

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay

S4T 7T1

Allan Blair Cancer Centre, Regina

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH