Safety and Quality of Life Study of Aflibercept in Patients With Metastatic Colorectal Cancer Previously Treated With an Oxaliplatin-Based Regimen

PHASE3CompletedINTERVENTIONAL
Enrollment

781

Participants

Timeline

Start Date

May 30, 2012

Primary Completion Date

January 31, 2017

Study Completion Date

January 31, 2017

Conditions
Colorectal Cancer Metastatic
Interventions
DRUG

AFLIBERCEPT AVE0005

Pharmaceutical form:Concentrate for solution for infusion Route of administration: Intravenous

DRUG

FOLFIRI

irinotecan, 5-FU and leucovorin

Trial Locations (179)

927

Investigational Site Number 630-001, Rio Peidras

2100

Investigational Site Number 208001, Cph Ø

2300

Investigational Site Number 056013, Turnhout

2650

Investigational Site Number 056001, Edegem

2820

Investigational Site Number 056004, Bonheiden

3400

Investigational Site Number 208003, Hillerød

4000

Investigational Site Number 056003, Liège

Investigational Site Number 056007, Liège

4800

Investigational Site Number 056002, Verviers

5000

Investigational Site Number 208002, Odense C

5021

Investigational Site Number 578002, Bergen

5530

Investigational Site Number 056011, Yvoir

6280

Investigational Site Number 056014, Loverval

6700

Investigational Site Number 056015, Arlon

7100

Investigational Site Number 056009, Haine-Saint-Paul

9000

Investigational Site Number 056012, Ghent

9300

Investigational Site Number 056010, Aalst

10003

Investigational Site Number 724012, Cáceres

10210

Investigational Site Number 764010, Laksi

10330

Investigational Site Number 764002, Bangkok

10400

Investigational Site Number 764003, Bangkok

Investigational Site Number 764008, Bangkok

10707

Investigational Site Number 276-011, Berlin

11042

Investigational Site Number 840-003, Lake Success

12808

Investigational Site Number 203002, Prague

14004

Investigational Site Number 724002, Córdoba

15000

Investigational Site Number 764007, Lopburi

15006

Investigational Site Number 203004, Prague

15706

Investigational Site Number 724006, Santiago de Compostela

16132

Investigational Site Number 380-001, Genova

20014

Investigational Site Number 724013, Donostia / San Sebastian

20520

Investigational Site Number 246002, Turku

20850

Investigational Site Number 840-001, Rockville

24128

Investigational Site Number 380-029, Bergamo

28007

Investigational Site Number 724003, Madrid

28034

Investigational Site Number 724015, Madrid

28041

Investigational Site Number 724005, Madrid

29010

Investigational Site Number 724004, Málaga

31096

Investigational Site Number 376002, Haifa

34093

Investigational Site Number 792012, Istanbul

34390

Investigational Site Number 792-02, Çapa

34865

Investigational Site Number 792-03, Istanbul

35100

Investigational Site Number 792-007, Izmir

35185

Investigational Site Number 752_001, Vaxjo

35661

Investigational Site Number 840-002, Muscle Shoals

37154

Investigational Site Number 276-015, Northeim

38440

Investigational Site Number 276-020, Wolfsburg

39008

Investigational Site Number 724011, Santander

39104

Investigational Site Number 276-018, Magdeburg

39130

Investigational Site Number 276-014, Magdeburg

40002

Investigational Site Number 764004, Khon Kaen

40133

Investigational Site Number 380-021, Bologna

42125

Investigational Site Number 380-008, Reggio Emilia

42551

Investigational Site Number 276-017, Velbert

45042

Investigational Site Number 840-005, Middletown

46009

Investigational Site Number 724001, Valencia

Investigational Site Number 724009, Valencia

46254

Investigational Site Number 840-006, Indianapolis

47441

Investigational Site Number 276-006, Moers

47805

Investigational Site Number 276-007, Krefeld

48903

Investigational Site Number 724008, Barakaldo

49100

Investigational Site Number 376005, Petah Tikva

50009

Investigational Site Number 724007, Zaragoza

50200

Investigational Site Number 764009, Chiang Mai

52621

Investigational Site Number 376004, Tel Litwinsky

55185

Investigational Site Number 752_002, Jönköping

57205

Investigational Site Number 484009, Mexico City

60100

Investigational Site Number 380-005, Ancona

60389

Investigational Site Number 276-009, Frankfurt am Main

60590

Investigational Site Number 276-013, Frankfurt am Main

63739

Investigational Site Number 276-016, Aschaffenburg

64060

Investigational Site Number 484001, Monterrey

64239

Investigational Site Number 376003, Tel Aviv

65653

Investigational Site Number 203005, Brno

66822

Investigational Site Number 276-003, Lebach

70006

Investigational Site Number 840-011, Metairie

70852

Investigational Site Number 203001, Ostrava

71640

Investigational Site Number 276-008, Ludwigsburg

77900

Investigational Site Number 203003, Olomouc

81377

Investigational Site Number 276-001, München

81737

Investigational Site Number 276-002, München

86150

Investigational Site Number 276-010, Augsburg

87106

Investigational Site Number 840-012, Albuquerque

87401

Investigational Site Number 840-009, Farmington

90220

Investigational Site Number 246001, Oulu

91054

Investigational Site Number 276-012, Erlangen

91120

Investigational Site Number 376001, Jerusalem

92501

Investigational Site Number 840-004, Riverside

92637

Investigational Site Number 276-005, Weiden/Oberpfalz

92708

Investigational Site Number 840-007, Fountain Valley

92879

Investigational Site Number 840-008, Corona

115478

Investigational Site Number 643001, Moscow

Investigational Site Number 643004, Moscow

Investigational Site Number 643005, Moscow

123448

Investigational Site Number 643002, Moscow

129301

Investigational Site Number 643006, Moscow

186646

Investigational Site Number 643009, Saint Petersburg

420029

Investigational Site Number 643003, Kazan'

07731

Investigational Site Number 840-010, Howell Township

70390-150

Investigational Site Number 008, Brasília

80530-010

Investigational Site Number 009, Curitiba

Unknown

Investigational Site Number 012, Fortaleza

Investigational Site Number 152001, Santiago

Investigational Site Number 152003, Santiago

Investigational Site Number 203006, Zlín

Investigational Site Number 372002, Dublin

Investigational Site Number 372004, Galway

Investigational Site Number 372001, Wilton

Investigational Site Number 380-004, Brescia

Investigational Site Number 380-007, Candiolo

Investigational Site Number 380-012, Catania

Investigational Site Number 380-019, Catanzaro

Investigational Site Number 380-023, Florence

Investigational Site Number 380-014, Meldola

Investigational Site Number 380-016, Messina

Investigational Site Number 380-013, Milan

Investigational Site Number 380-015, Milan

Investigational Site Number 380-025, Milan

Investigational Site Number 380-022, Napoli

Investigational Site Number 380-028, Novara

Investigational Site Number 380-017, Padua

Investigational Site Number 380-002, Pisa

Investigational Site Number 380-010, Roma

Investigational Site Number 380-011, Roma

Investigational Site Number 380-006, San Giovanni Rotondo

Investigational Site Number 380-026, Sassari

Investigational Site Number 380-020, Terni

Investigational Site Number 380-009, Torino

Investigational Site Number 380-003, Udine

Investigational Site Number 380-018, Verona

Investigational Site Number 1, Beirut

Investigational Site Number 764001, Bangkok

Investigational Site Number 764006, Bangkok

Investigational Site Number 764005, Bangkok,TH

Investigational Site Number 792-08, Ankara

Investigational Site Number 792010, Edirne

Investigational Site Number 792-05, Gaziantep

Investigational Site Number 792-04, Istanbul

Investigational Site Number 792011, Izmir

99010-260

Investigational Site Number 006, Passo Fundo

90470-340

Investigational Site Number 003, Porto Alegre

22793-080

Investigational Site Number 002, Rio de Janeiro

40170-070

Investigational Site Number 011, Salvador

15090-000

Investigational Site Number 013, São José do Rio Preto

01246-000

Investigational Site Number 001, São Paulo

01308-050

Investigational Site Number 004, São Paulo

01321-000

Investigational Site Number 005, São Paulo

T2N 4N2

Investigational Site Number 124002, Calgary

H1T 2M4

Investigational Site Number 124003, Montreal

H2W1S6

Investigational Site Number 124005, Montreal

K1H8L6

Investigational Site Number 124004, Ottawa

G1S4L8

Investigational Site Number 124006, Québec

M4N3M5

Investigational Site Number 124001, Toronto

06120

Investigational Site Number 276-004, Halle

04103

Investigational Site Number 276-019, Leipzig

00189

Investigational Site Number 380-024, Roma

06760

Investigational Site Number 484002, Mexico City

06726

Investigational Site Number 484010, México, D.F.

2134TM

Investigational Site Number 528001, Hoofddorp

8025AB

Investigational Site Number 528002, Zwolle

0407

Investigational Site Number 578001, Oslo

03010

Investigational Site Number 724016, Alicante

08907

Investigational Site Number 724014, L'Hospitalet de Llobregat

08208

Investigational Site Number 724010, Sabadell

01250

Investigational Site Number 792-06, Adana

06100

Investigational Site Number 792-01, Ankara

06200

Investigational Site Number 792-09, Ankara

DY1 2HQ

Investigational Site Number 826005, Dudley

HU165JQ

Investigational Site Number 826011, Hull

LE15WW

Investigational Site Number 826008, Leicester

NW1 2PJ

Investigational Site Number 826007, London

SE17EH

Investigational Site Number 826012, London

ME169QQ

Investigational Site Number 826003, Maidstone

M204BX

Investigational Site Number 826009, Manchester

NE77DN

Investigational Site Number 826004, Newcastle upon Tyne

HA62RN

Investigational Site Number 826006, Northwood

SO60YD

Investigational Site Number 826002, Southampton

SM25PT

Investigational Site Number 826001, Sutton

TA15DA

Investigational Site Number 826010, Taunton

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Regeneron Pharmaceuticals

INDUSTRY

lead

Sanofi

INDUSTRY