The Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Placebo and Best Supportive Care in Subjects With Red Blood Cell (RBC) Transfusion-Dependent Anemia and Thrombocytopenia Due to International Prognostic Scoring System (IPSS) Low Risk Myelodysplastic Syndrome (MDS)

PHASE3CompletedINTERVENTIONAL
Enrollment

216

Participants

Timeline

Start Date

April 26, 2013

Primary Completion Date

January 25, 2019

Study Completion Date

December 21, 2023

Conditions
Myelodysplastic Syndrome
Interventions
DRUG

Oral Azacitidine

300 mg daily, days 1 to 21 of each 28-day treatment cycle

DRUG

Placebo

Identically matching placebo tablets on day 1 to 21 of each 28-day treatment cycle.

OTHER

Best Supportiv Care (BSC)

BSC included and was not limited to packed RBC (packed red blood cell \[pRBC\] and whole blood), platelet transfusions (single donor or pooled donor), antibiotic, antiviral and/or antifungal therapy, nutritional support, and granulocyte colony stimulating factors (G-CSF) for participants who experienced neutropenic fever/infections.

Trial Locations (196)

1009

Local Institution - 633, Vitoria-Gasteiz, Álava

2050

Local Institution - 131, Camperdown

2217

Local Institution - 135, Kogarah

2605

Local Institution - 137, Garran

2930

Local Institution - 203, Brasschaat

3000

Local Institution - 201, Leuven

3065

Local Institution - 133, Fitzroy

3076

Local Institution - 127, Epping, VIC

3144

Local Institution - 130, Malvern

3168

Local Institution - 134, Clayton

3199

Local Institution - 132, Frankston

4064

Local Institution - 126, Milton, Brisbane

5000

Local Institution - 252, Odense C

6000

Local Institution - 202, Charleroi

6807

Local Institution - 552, Førde

7575

Local Institution - 308, Paris

8000

Local Institution - 200, Bruges

Local Institution - 253, Aarhus

8035

Local Institution - 625, Barcelona

8916

Local Institution - 626, Badalona (Barcelona)

10021

Weill Cornell Medical College - New York - Presbyterian Hospital, New York

10029

Icahn School of Medicine at Mount Sinai Medical Center, New York

10126

Local Institution - 477, Torino

10676

Local Institution - 852, Athens

13009

Local Institution - 304, Marseille

14080

Local Institution - 827, Tlalpan

14186

Local Institution - 651, Stockholm

15121

Local Institution - 482, Alessandria

15224

Western Pennsylvania Cancer Institute, Pittsburgh

18014

Local Institution - 636, Granada

19104

Penn Medicine: University of Pennsylvania Health System, Philadelphia

20089

Local Institution - 498, Milan

20122

Local Institution - 488, Milan

20521

Local Institution - 277, Turku

21231

Johns Hopkins Medicine, Baltimore

24105

Local Institution - 353, Keil

26500

Local Institution - 854, Pátrai

27100

Local Institution - 495, Pavia

27834

Eastern Institute of Medical Sciences, Greenville

28009

Local Institution - 629, Madrid

28034

Local Institution - 634, Madrid

28046

Local Institution - 631, Madrid

28100

Local Institution - 497, Novara

28204

Levine Cancer Institute, Charlotte

29010

Local Institution - 632, Málaga

30174

Local Institution - 476, Venezia - Mestre

31059

Local Institution - 300, Toulouse

31096

Local Institution - 453, Haifa

31701

Phoebe Cancer Center of Phoebe Putney Memorial Hospital, Albany

32806

University of Florida Health Cancer Center at Orlando Health, Orlando

33006

Local Institution - 628, Oviedo

33100

Local Institution - 478, Udine

33343

Local Institution - 404, Mersin

34098

Local Institution - 403, Istanbul

34390

Local Institution - 400, Istanbul

35033

Local Institution - 302, Rennes

37007

Local Institution - 630, Salamanca

37044

Local Institution - 309, Tours

39202

Jackson Oncology Associates PLLC, Jackson

40138

Local Institution - 489, Bologna

40202

University of Louisville, J.G. Brown Cancer Center, Louisville

40225

Local Institution - 355, Düsseldorf

40479

Local Institution - 359, Düsseldorf

41013

Local Institution - 627, Seville

43210

Ohio State University Medical Center, Columbus

44093

Local Institution - 301, Nantes

49100

Local Institution - 451, Petah Tikva

50129

Local Institution - 486, Florence

52621

Local Institution - 454, Tel Litwinsky

52763

Local Institution - 830, Huixquilucan de Degollado

55905

Mayo Clinic, Rochester

56126

Local Institution - 496, Pisa

59037

Local Institution - 305, Lille

60020

Local Institution - 493, Torrette Di Ancona

60153

Loyola University Chicago, Maywood

60611

Robert H Lurie Comprehensive Cancer Center NW Univ, Chicago

60612

University Of Illinois At Chicago, Chicago

60637

University Of Chicago Medical Center, Chicago

61080

Local Institution - 402, Trabzon

64111

Saint Luke's Cancer Institute, Kansas City

64128

Kansas City VA Medical Center University of Kansas Medical Center, Kansas City

64239

Local Institution - 452, Tel Aviv

64460

Local Institution - 828, Monterrey

64710

Local Institution - 829, Monterrey

67091

Local Institution - 306, Strasbourg

68100

Local Institution - 851, Alexandroupoli

69495

Local Institution - 307, Pierre-Bénite

70006

Hematology And Oncology Specialists, Llc, Metairie

70124

Local Institution - 492, Bari

71110

Local Institution - 853, Heraklion

72076

Local Institution - 357, Tübingen

73100

Local Institution - 479, Lecce

76038

Local Institution - 303, Rouen

77030

Local Institution - 900, Houston

Local Institution - 924, Houston

77090

Millennium Physicians - Oncology, Houston

77520

Local Institution - 229, Olomouc

81675

Local Institution - 352, München

85028

Local Institution - 484, Rionero in Vulture

89081

Local Institution - 360, Ulm

89133

Local Institution - 485, Reggio Calabria

90033

University of Southern California Norris Cancer Center, Los Angeles

90146

Local Institution - 480, Palermo

90211

Tower Hematology/Oncology Medical Group and Tower Cancer Research Found, Beverly Hills

92025

California Cancer Associates for Research and Excellence cCARE, Escondido

94704

Alta Bates Comprehensive Cancer Center, Berkeley

97227

Local Institution - 917, Portland

60430370

Local Institution - 154, Fortaleza

91010-301

City Of Hope, Duarte

94904-2007

Marin Oncology Associates, Greenbrae

92093-0943

UCSD-Thornton Hospital, La Jolla

06519

Local Institution - 942, New Haven

66160-7233

University Of Kansas Medical Center, Kansas City

01655

UMASS Memorial Hospital, Worcester

68198-6805

University Of Nebraska Medical Center, Omaha

44106-5000

University Hospitals of Cleveland Case Medical Center, Cleveland

78235-8200

Brooke Army Medical Center Francis Street Medical Center, Fort Sam Houston

23298-0037

VA Commonwealth University - Massey Cancer Center, Richmond

98109-4417

Local Institution - 904, Seattle

53188-5099

Waukesha Memorial Hospital, Waukesha

SA 5000

Local Institution - 129, Adelaide

NSW

Local Institution - 138, Waratah

QLD 4102

Local Institution - 136, Woolloongabba

81520-060

Local Institution - 155, Curitiba

90035-903

Local Institution - 152, Porto Alegre

20231-130

Local Institution - 153, Rio de Janeiro

05651-901

Local Institution - 151, São Paulo

T6G 2B7

Local Institution - 182, Edmonton

V5Z 1M9

Local Institution - 178, Vancouver

LYM6M2

Local Institution - 183, Barrie

L8V 5C2

Local Institution - 180, Hamilton

M4N 3M5

Local Institution - 179, Toronto

M5G 2M9

Local Institution - 176, Toronto

H2W 1S6

Local Institution - 181, Montreal

H4J 1C5

Local Institution - 177, Montreal

625 00

Local Institution - 226, Brno

500 05

Local Institution - 230, Hradec Králové

128 08

Local Institution - 228, Prague

128 20

Local Institution - 227, Prague

DK-4000

Local Institution - 251, Roskilde

00029 HUS

Local Institution - 276, Helsinki

01307

Local Institution - 350, Dresden

Local Institution - 361, Dresden

D-20099

Local Institution - 356, Hamburg

04103

Local Institution - 351, Leipzig

115 27

Local Institution - 855, Athens

124 62

Local Institution - 850, Athens

09121

Local Institution - 494, Cagliari

00133

Local Institution - 487, Roma

00161

Local Institution - 490, Roma

00168

Local Institution - 481, Roma

05100

Local Institution - 499, Terni

1081 HV

Local Institution - 528, Amsterdam

9713 GZ

Local Institution - 527, Groningen

6500 HB

Local Institution - 526, Nijmegen

3075 EA

Local Institution - 529, Rotterdam

N-0027

Local Institution - 551, Oslo

85-168

Local Institution - 582, Bydgoszcz

80-952

Local Institution - 576, Gdansk

31-501

Local Institution - 579, Krakow

93-510

Local Institution - 581, Lodz

87-100

Local Institution - 580, Torun

02-097

Local Institution - 583, Warsaw

02-776

Local Institution - 577, Warsaw

50-367

Local Institution - 578, Wroclaw

7801-849

Local Institution - 604, Beja

3000-075

Local Institution - 600, Coimbra

1099-023

Local Institution - 601, Lisbon

1150-314

Local Institution - 603, Lisbon

4200-072

Local Institution - 602, Porto

614-735

Local Institution - 704, Busan

700-721

Local Institution - 703, Daegu

06591

Local Institution - 701, Seoul

120-752

Local Institution - 702, Seoul

135-710

Local Institution - 700, Seoul

08025

Local Institution - 635, Barcelona

413 45

Local Institution - 653, Gothenburg

222 41

Local Institution - 652, Lund

01250

Local Institution - 401, Adana

07100

Local Institution - 405, Antalya

OX3 9DU

Local Institution - 685, Oxford

AB25 2ZN

Local Institution - 687, Aberdeen

B9 5SS

Local Institution - 691, Birmingham

BS2 8ED

Local Institution - 686, Bristol

CB2 0QQ

Local Institution - 689, Cambridge

CF14 4XW

Local Institution - 678, Cardiff

HA1 3UJ

Local Institution - 688, Harrow Middlesex

HU16 5JQ

Local Institution - 692, Hull

LE1 5WW

Local Institution - 677, Leicester

L7 8XP

Local Institution - 683, Liverpool

EC1A 7BE

Local Institution - 676, London

SE1 9RT

Local Institution - 684, London

M13 9WL

Local Institution - 679, Manchester

NG5 1PB

Local Institution - 681, Nottingham

NG17 4JL

Local Institution - 690, Sutton in Ashfield

WV10 0QP

Local Institution - 680, Wolverhampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY

NCT01566695 - The Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Placebo and Best Supportive Care in Subjects With Red Blood Cell (RBC) Transfusion-Dependent Anemia and Thrombocytopenia Due to International Prognostic Scoring System (IPSS) Low Risk Myelodysplastic Syndrome (MDS) | Biotech Hunter | Biotech Hunter