500
Participants
Start Date
November 8, 2012
Primary Completion Date
February 28, 2026
Study Completion Date
December 31, 2026
Paclitaxel
Paclitaxel 80 mg/m2 (capped at 162mg maximum total dose) weekly for 6 weeks i.e. on days 1, 8, 15, 22, 29 \& 36.
Carboplatin
Carboplatin AUC 2 (capped at 270mg maximum total dose) weekly for 6 weeks i.e. on day 1, 8, 15, 22, 29, \& 36.
Radiotherapy
Radiotherapy comprising external beam 40-50.4Gy in 20-28 fractions plus intracavity brachytherapy to achieve a minimum total EQD2 dose of 78-86Gy.
Cisplatin
Cisplatin 40 mg/m2 (capped at 70mg total dose) weekly for five weeks maximum, commencing in the first week of radiotherapy or as soon as blood counts have recovered from induction chemotherapy.
Istituto Europeo di Oncologia, Milan
Instituto do Câncer do Estado de São Paulo, São Paulo
Chittaranjan National Cancer Institute (CNCI), Kolkata
Saroj Gupta Cancer Centre and Research Institute, Kolkata
Instituto Nacional de Cancerologia (INCAN), Mexico City
Belfast City Hospital, Belfast
Pilgrim Hospital, Boston
Royal Sussex County Hospital, Brighton
Velindre Cancer Centre, Cardiff
Cheltenham General Hospital, Cheltenham
Royal Derby Hospital, Derby
Beatson WOSCC, Glasgow
Gloucester Royal Hospital, Gloucester
Grantham and District Hospital, Grantham
Castle Hill Hospital, Hull
Leicester Royal Infirmary, Leicester
Lincoln County Hospital, Lincoln
Guy's and St Thomas' NHS Foundation Trust, London
Imperial College Healthcare NHS Trust, London
St Bart's Hospital, London
The Clatterbridge Cancer Centre, Metropolitan Borough of Wirral
James Cook University Hospital, Middlesbrough
Northampton General Hospital, Northampton
Norfolk and Norwich University Hospital, Norwich
Derriford Hospital, Plymouth
Southampton General Hospital, Southampton
Royal Stoke University Hospital, Stoke-on-Trent
Royal Cornwall Hospital, Truro
New Cross Hospital, Wolverhampton
North Devon District Hospital, Barnstaple
University College London Hospital, London
Weston Park Hospital, Sheffield
Royal Devon and Exeter NHS Foundation Trust, Exeter
The Christie NHS Foundation Trust, Manchester
Nottingham University Hospitals NHS Trust, Nottingham
Collaborators (1)
Cancer Research UK
OTHER
University College, London
OTHER