239
Participants
Start Date
May 31, 2012
Primary Completion Date
November 1, 2021
Study Completion Date
September 4, 2025
GnRH agonist
LHRH agonists are administered with a variety of techniques. The manufacturer's instructions should be followed. Begins within 6 weeks after registration (if not started prior) at same time as anti-androgen and TAK-700 (if applicable).
Anti-androgen
Starts at same time as GnRH agonist, ends at end of radiation therapy. Either flutamide (orally 250 mg three times a day) or bicalutamide (orally 50 mg once a day).
TAK-700
300 mg twice daily (BID) (600 mg per day) orally, continuously for 2 years starting with ADT.
Radiation therapy
Starts 8-10 weeks after initiation of ADT. Initially 45 Gy (1.8 Gy / fraction) to prostate and pelvic lymph nodes delivered with 3DCRT/IMRT, then a boost using intensity-modulated radiation therapy (IMRT), low dose rate (LDR) brachytherapy, or high dose rate (HDR) brachytherapy.
The Regional Cancer Center, Erie
Adams Cancer Center, Gettysburg
Cherry Tree Cancer Center, Hanover
WellSpan Health-York Hospital, York
Delaware County Memorial Hospital, Drexel Hill
Lankenau Hospital, Wynnewood
Thomas Jefferson University Hospital, Philadelphia
Fox Chase Cancer Center, Philadelphia
Temple University Hospital, Philadelphia
Paoli Memorial Hospital, Paoli
Reading Hospital, West Reading
Helen F Graham Cancer Center, Newark
Christiana Care Health System-Christiana Hospital, Newark
Saint Agnes Hospital, Baltimore
Peninsula Regional Medical Center, Salisbury
Sentara Virginia Beach General Hospital, Virginia Beach
Sentara Hospitals, Norfolk
Sentara Cancer Institute at Sentara CarePlex Hospital, Hampton
Oncology and Hematology Associates of Southwest Virginia, Roanoke
Lexington Medical Center, West Columbia
Spartanburg Regional Medical Center, Spartanburg
Gibbs Cancer Center-Pelham, Greer
Atlanta VA Medical Center, Decatur
Grady Health System, Atlanta
Piedmont Hospital, Atlanta
Emory University/Winship Cancer Institute, Atlanta
Saint Joseph's-Candler Health System, Savannah
Florida Hospital, Orlando
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
The Kirklin Clinic at Acton Road, Birmingham
University of Alabama at Birmingham, Birmingham
University of Kentucky, Lexington
Ohio State University Medical Center, Columbus
Flower Hospital, Sylvania
Geaugra Hospital, Chardon
Mercy Cancer Center-Elyria, Elyria
Lake University Ireland Cancer Center, Mentor
Case Western Reserve University, Cleveland
UHHS-Chagrin Highlands Medical Center, Orange
Southwest General Health Center Ireland Cancer Center, Middleburg Heights
UHHS-Westlake Medical Center, Westlake
Cleveland Clinic Foundation, Cleveland
Summa Barberton Hospital, Barberton
Summa Health Center at Lake Medina, Medina
Robinson Radiation Oncology, Ravenna
Summa Akron City Hospital/Cooper Cancer Center, Akron
Akron General Medical Center, Akron
Ireland Cancer Center at Firelands Regional Medical Center, Sandusky
University of Cincinnati, Cincinnati
Radiation Oncology Associates PC, Fort Wayne
Parkview Hospital Randallia, Fort Wayne
William Beaumont Hospital-Royal Oak, Royal Oak
William Beaumont Hospital - Troy, Troy
University of Michigan, Ann Arbor
Great Lakes Cancer Institute-Lapeer Campus, Lapeer
McLaren-Flint, Flint
McLaren Cancer Institute-Owosso, Owosso
West Michigan Cancer Center, Kalamazoo
Bixby Medical Center, Adrian
Northern Michigan Regional Hospital, Petoskey
University of Iowa Hospitals and Clinics, Iowa City
Columbia Saint Mary's Hospital - Ozaukee, Mequon
Columbia Saint Mary's Water Tower Medical Commons, Milwaukee
Froedtert and the Medical College of Wisconsin, Milwaukee
Clement J. Zablocki VA Medical Center, Milwaukee
Wheaton Franciscan Cancer Care - All Saints, Racine
Bay Area Medical Center, Marinette
Saint Vincent Hospital, Green Bay
Saint Mary's Hospital, Green Bay
Gundersen Lutheran, La Crosse
Appleton Medical Center, Appleton
Regions Hospital, Saint Paul
Saint Luke's Hospital of Duluth, Duluth
Sanford Clinic North-Bemidgi, Bemidji
Rapid City Regional Hospital, Rapid City
Sanford Medical Center-Fargo, Fargo
Sanford Bismarck Medical Center, Bismarck
Benefis Healthcare- Sletten Cancer Institute, Great Falls
Hines Veterans Administration Hospital, Hines
Loyola University Medical Center, Maywood
Weiss Memorial Hospital, Chicago
OSF Saint Francis Medical Center, Peoria
Decatur Memorial Hospital, Decatur
Washington University School of Medicine, St Louis
Siteman Cancer Center-South County, St Louis
Missouri Baptist Medical Center, St Louis
Barnes-Jewish West County Hospital, St Louis
Saint John's Mercy Medical Center, St Louis
Siteman Cancer Center - Saint Peters, City of Saint Peters
Southeast Cancer Center, Cape Girardeau
Kansas City Cancer Center-Lee's Summit, Lee's Summit
Kansas City Cancer Center - South, Kansas City
Kansas City Cancer Centers - North, Kansas City
Mercy Hospital Springfield, Springfield
University of Kansas Medical Center, Kansas City
Kansas City Cancer Centers-Southwest, Overland Park
Nebraska Methodist Hospital, Omaha
The Nebraska Medical Center, Omaha
Touro Infirmary, New Orleans
Ochsner Medical Center Jefferson, New Orleans
Mary Bird Perkins Cancer Center, Baton Rouge
University of Oklahoma Health Sciences Center, Oklahoma City
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa
Texas Cancer Center-Sherman, Sherman
University of Texas Southwestern Medical Center, Dallas
Texas Oncology PA - Bedford, Bedford
The Klabzuba Cancer Center, Fort Worth
Memorial Hermann Memorial City Medical Center, Houston
M D Anderson Cancer Center, Houston
Texas Oncology Cancer Center Sugar Land, Sugar Land
UTMB Cancer Center at Victory Lakes, League City
University of Colorado Cancer Center - Anschutz Cancer Pavilion, Aurora
Poudre Valley Radiation Oncology, Fort Collins
Idaho Urologic Institute PA, Meridian
Saint Alphonsus Regional Medical Center, Boise
Utah Cancer Specialists-Salt Lake City, Salt Lake City
Intermountain Medical Center, Murray
Dixie Medical Center Regional Cancer Center, St. George
Arizona Oncology-Deer Valley Center, Phoenix
Arizona Oncology Services Foundation, Scottsdale
Los Angeles County-USC Medical Center, Los Angeles
University of Southern California/Norris Cancer Center, Los Angeles
Cedars-Sinai Medical Center, Los Angeles
Veterans Administration Long Beach Medical Center, Long Beach
Pomona Valley Hospital Medical Center, Pomona
University of California At San Diego, San Diego
Kaiser Permanente Cancer Treatment Center, South San Francisco
UCSF-Mount Zion, San Francisco
Stanford University Hospitals and Clinics, Stanford
Sutter Solano Medical Center, Vallejo
Rohnert Park Cancer Center, Rohnert Park
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn
Mercy San Juan Medical Center, Carmichael
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville
Sutter General Hospital, Sacramento
Queen's Medical Center, Honolulu
Rogue Valley Medical Center, Medford
Saint Francis Hospital, Federal Way
Virginia Mason CCOP, Seattle
Hartford Hospital, Hartford
The Hospital of Central Connecticut, New Britain
William Backus Hospital, Norwich
Maine Medical Center- Scarborough Campus, Scarborough
Massachusetts General Hospital Cancer Center, Boston
Brigham and Women's Hospital, Boston
Dana-Farber Cancer Institute, Boston
Beth Israel Deaconess Medical Center, Boston
Saint Anne's Hospital, Fall River
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford
North Shore Medical Center Cancer Center, Peabody
Dana-Farber/Brigham and Women's Cancer Center at South Shore, South Weymouth
Saint Joseph Mercy Hospital, Ann Arbor
Concord Hospital, Concord
Exeter Hospital, Exeter
Dartmouth Hitchcock Medical Center, Lebanon
Elliot Hospital, Manchester
Cooper Hospital University Medical Center, Camden
Saint Peter's University Hospital, New Brunswick
MD Anderson Cancer Center at Cooper-Voorhees, Voorhees Township
University of Texas Medical Branch at Galveston, Galveston
Door County Cancer Center, Sturgeon Bay
Tom Baker Cancer Centre, Calgary
BCCA-Cancer Centre for the Southern Interior, Kelowna
London Regional Cancer Program, London
Ottawa Health Research Institute-General Division, Ottawa
CHUM - Hopital Notre-Dame, Montreal
Allan Blair Cancer Centre, Regina
Saskatoon Cancer Centre, Saskatoon
Collaborators (1)
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER
Radiation Therapy Oncology Group
NETWORK