Sirolimus and Vismodegib in Treating Patients With Solid Tumors or Pancreatic Cancer That is Metastatic or Cannot Be Removed By Surgery

PHASE1CompletedINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

March 5, 2012

Primary Completion Date

June 27, 2018

Study Completion Date

June 27, 2018

Conditions
Acinar Cell Adenocarcinoma of the PancreasDuct Cell Adenocarcinoma of the PancreasRecurrent Pancreatic CancerStage IV Pancreatic CancerUnspecified Adult Solid Tumor, Protocol Specific
Interventions
DRUG

vismodegib

Given PO

DRUG

sirolimus

Given PO

PROCEDURE

positron emission tomography

Correlative studies

PROCEDURE

computed tomography

Correlative studies

OTHER

pharmacological study

Correlative studies

OTHER

laboratory biomarker analysis

Correlative studies

RADIATION

fludeoxyglucose F 18

Correlative studies

Trial Locations (3)

32224

Mayo Clinic Campus in Florida, Jacksonville

55905

Mayo Clinic, Rochester

Unknown

Mayo Clinic Campus in Arizona, Scottsdale

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER