Oral Ondansetron Versus Transdermal Granisetron (Sancuso) for Women With Cervical, Endometrial or Vaginal Cancer Receiving Pelvic Chemoradiation

PHASE3CompletedINTERVENTIONAL
Enrollment

76

Participants

Timeline

Start Date

March 31, 2012

Primary Completion Date

October 3, 2019

Study Completion Date

October 3, 2019

Conditions
Cancer of the Cervix
Interventions
DRUG

Granisetron

34.3 mg of granisetron formulated in a transdermal patch replaced every 7 days. At cycle 1, participants receive granisetron by vein prior to IV cisplatin and prior to administration of transdermal patch.

DRUG

Ondansetron

8 mg of ondansetron by mouth three times a day starting with cisplatin administration and continued for 72 hours after chemotherapy infusion.

BEHAVIORAL

Questionnaires

Completion of 3 questionnaires at study visits taking about 5 minutes each time.

BEHAVIORAL

Study Drug Diary

Study drug diary to record times that study drugs taken, and to record any nausea or vomiting experienced.

Trial Locations (2)

77026

Lyndon B. Johnson General Hospital, Houston

77030

University of Texas MD Anderson Cancer Center, Houston

All Listed Sponsors
lead

M.D. Anderson Cancer Center

OTHER

collaborator

Sancuso

INDUSTRY

NCT01536392 - Oral Ondansetron Versus Transdermal Granisetron (Sancuso) for Women With Cervical, Endometrial or Vaginal Cancer Receiving Pelvic Chemoradiation | Biotech Hunter | Biotech Hunter