Everolimus Plus Best Supportive Care vs Placebo Plus Best Supportive Care in the Treatment of Patients With Advanced Neuroendocrine Tumors (GI or Lung Origin)

PHASE3CompletedINTERVENTIONAL
Enrollment

302

Participants

Timeline

Start Date

March 30, 2012

Primary Completion Date

November 28, 2014

Study Completion Date

August 7, 2020

Conditions
Advanced NET of GI OriginAdvanced NET of Lung OriginNeuroendocrine Tumors
Interventions
DRUG

Everolimus

Participants were treated with everolimus 10 mg (two 5 mg tablets) once daily orally taken

DRUG

Placebo

Participants were treated with two tablets of matching placebo once daily orally taken.

OTHER

Best suportive care (BSC)

Best supportive care includes all care provided to participants deemed necessary by the treating physician, such as but not restricted to anti-diarrheals and analgesics. The optimal care of the patient is based on the treating physician's best medical judgment.

Trial Locations (97)

833

Novartis Investigative Site, Kaohsiung City

1062

Novartis Investigative Site, Budapest

1085

Novartis Investigative Site, Budapest

1200

Novartis Investigative Site, Brussels

2193

Novartis Investigative Site, Parktown

2650

Novartis Investigative Site, Edegem

3000

Novartis Investigative Site, Leuven

6020

Novartis Investigative Site, Innsbruck

9000

Novartis Investigative Site, Ghent

10017

Memorial Sloan Kettering MSkCC SC, New York

10048

Novartis Investigative Site, Taipei

10330

Novartis Investigative Site, Bangkok

10467

Montefiore Medical Center MMC, The Bronx

11211

Novartis Investigative Site, Riyadh

11217

Novartis Investigative Site, Taipei

12808

Novartis Investigative Site, Prague

13353

Novartis Investigative Site, Berlin

20089

Novartis Investigative Site, Rozzano

20133

Novartis Investigative Site, Milan

20141

Novartis Investigative Site, Milan

25123

Novartis Investigative Site, Brescia

27310

Novartis Investigative Site, Gaziantep

30625

Novartis Investigative Site, Hanover

33305

Novartis Investigative Site, Kuei-Shan Chiang

33612

H Lee Moffitt Cancer Center and Research Institute HLM, Tampa

34303

Novartis Investigative Site, Istanbul

37126

Novartis Investigative Site, Verona

37232

Vanderbilt University Medical Center Vanderbilt Med Ctr, Nashville

39120

Novartis Investigative Site, Magdeburg

40138

Novartis Investigative Site, Bologna

40705

Novartis Investigative Site, Taichung

41009

Novartis Investigative Site, Seville

41124

Novartis Investigative Site, Modena

45147

Novartis Investigative Site, Essen

46202

Goshen Center for Cancer Care IU Health SC, Indianapolis

50134

Novartis Investigative Site, Florence

50200

Novartis Investigative Site, Chiang Mai

55131

Novartis Investigative Site, Mainz

60590

Novartis Investigative Site, Frankfurt

60637

University of Chicago UC SC, Chicago

65653

Novartis Investigative Site, Brno

75251

Texas Oncology P A Texas Oncology Amarillo, Dallas

Texas Oncology P A TX Oncology Baylor, Dallas

75390

University of Texas Southwestern Medical Center, Dallas

77030

University of Texas MD Anderson Cancer Center UT MD Anderson Cancer Ctr, Houston

80045

University of Colorado Cancer Centre SC, Aurora

80131

Novartis Investigative Site, Napoli

80132

Novartis Investigative Site, Napoli

90048

Cedars Sinai Medical Center SC, Los Angeles

92121

Scripps Clinic Regulatory, La Jolla

95029

Novartis Investigative Site, Viagrande

97239

Oregon Health and Science University OH&SU, Portland

99438

Novartis Investigative Site, Bad Berka

100021

Novartis Investigative Site, Beijing

100029

Novartis Investigative Site, Beijing

100036

Novartis Investigative Site, Beijing

100039

Novartis Investigative Site, Beijing

100730

Novartis Investigative Site, Beijing

166830

Novartis Investigative Site, El Achrafiyé

344037

Novartis Investigative Site, Rostov-on-Don

92093-0658

University of California San Diego - Moores Cancer Center Regulatory, La Jolla

02215

Dana Farber Cancer Institute SC, Boston

53792-6164

University of Wisconsin / Paul P. Carbone Comp Cancer Center Univ Wisc, Madison

A-1090

Novartis Investigative Site, Vienna

T2N 4N2

Novartis Investigative Site, Calgary

V5Z 4E6

Novartis Investigative Site, Vancouver

B3H 1V7

Novartis Investigative Site, Halifax

N6A 4L6

Novartis Investigative Site, London

K1H 8L6

Novartis Investigative Site, Ottawa

M4N 3M5

Novartis Investigative Site, Toronto

H1T 2M4

Novartis Investigative Site, Montreal

Unknown

Novartis Investigative Site, Bogotá

775 20

Novartis Investigative Site, Olomouc

115 27

Novartis Investigative Site, Athens

00168

Novartis Investigative Site, Roma

00189

Novartis Investigative Site, Roma

812-8582

Novartis Investigative Site, Fukuoka

553-0003

Novartis Investigative Site, Osaka

104 0045

Novartis Investigative Site, Chuo Ku

1107 2020

Novartis Investigative Site, Beirut

1066 CX

Novartis Investigative Site, Amsterdam

44-101

Novartis Investigative Site, Gliwice

60-355

Novartis Investigative Site, Poznan

833 10

Novartis Investigative Site, Bratislava

05505

Novartis Investigative Site, Seoul

06591

Novartis Investigative Site, Seoul

03080

Novartis Investigative Site, Seoul

03722

Novartis Investigative Site, Seoul

06351

Novartis Investigative Site, Seoul

08035

Novartis Investigative Site, Barcelona

08907

Novartis Investigative Site, L'Hospitalet de Llobregat

G12 0YN

Novartis Investigative Site, Glasgow

CB2 2QQ

Novartis Investigative Site, Cambridge

SE1 9RT

Novartis Investigative Site, London

W12 0HS

Novartis Investigative Site, London

M20 2BX

Novartis Investigative Site, Manchester

SO16 6YD

Novartis Investigative Site, Southampton

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY