LUX-Lung 8: A Phase III Trial of Afatinib (BIBW 2992) Versus Erlotinib for the Treatment of Squamous Cell Lung Cancer After at Least One Prior Platinum Based Chemotherapy

PHASE3CompletedINTERVENTIONAL
Enrollment

795

Participants

Timeline

Start Date

March 5, 2012

Primary Completion Date

October 21, 2013

Study Completion Date

December 27, 2017

Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG

afatinib

Afatinib taken once daily, continuously until disease progression or unacceptable toxicity.

DRUG

erlotinib

erlotinib taken once daily

Trial Locations (192)

100

National Taiwan University Hospital, Taipei

112

Koo Foundation Sun Yet-Sen Cancer Center, Taipei

Taipe Veterans General Hospital, Taipei

330

Chang Gung Memorial Hospital(TaoYuan), Taoyuan District

404

China Medical University Hospital, Taichung

407

Taichung Veterans General Hospital, Taichung

613

Chang Gung Memorial Hospital Chiayi, Chiayi City

622

Buddhist Tzu Chi General Hospital, Chiayi City

833

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City

1121

National Koranyi TBC and Pulm. Internal Med. Clinic, Budapest

1125

Semmelweis University, Budapest

1140

SMZ Baumgartner Hoehe Otto Wagner Spital, Vienna

2045

Pest County Lung Hospital, Department No. 3, Törökbálint

2730

Herlev Hospital, Herlev

3233

Lung Hospital of Matra, Dept. Pulmonology, Mátraháza

4020

AKH d. Stadt Linz, Pulmologie, Linz

4400

Josa Andras Korhaz, Nyiregyhaza, Nyíregyháza

4700

Næstved Sygehus, Næstved

5000

Odense Universitetshospital, Odense C

6020

Medical University of Innsbruck, Innsbruck

6772

Institute of Chest Diseases Csongrad County,Dpt. Pulmonology, Deszk

7623

University of Pecs, 1st internal Med. Dept., Pulmonology, Pécs

8582

Pulmonology Institute of Veszprem County, Farkasgyepu, Farkasgyepü

8700

LKH Leoben, Leoben

9023

Aladar Petz County Teaching Hospital, Dept. Pulmonology, Győr

10126

Ospedale Molinette, AO Città della Salute e della, Torino

10461

Montefiore Medical Center, The Bronx

10467

Montefiore Medical Center, The Bronx

11366

Queens Medical Associates, Fresh Meadows

11527

"Hippokratio Hospital of Athens, 2nd Internal Medicine Clin", Athens

General Hospital of Chest Diseases Sotiria, Athens

13210

SUNY Upstate Medical University, Syracuse

13273

INS Paoli-Calmettes, Marseille

13620

Seoul National University Bundang Hospital, Seongnam

13915

HOP Nord, Marseille

14033

HOP Côte de Nacre, Caen

14080

Instituto Nacional de Cancerologia, México

15006

Hospital A Coruña, A Coruña

15801

Oncology Hematology Associates of Norhtern Pennsylvania, PC, DuBois

16045

Uludag Universitesi Tip Fakultesi, Bursa, Bursa

18547

Metropolitan Hospital, Oncology Clinic, Neo Faliro, Athens

19107

Kimmel Cancer Center, Philadelphia

19140

Temple University Cancer Center, Philadelphia

20089

Istituto Clinico Humanitas, Rozzano (MI)

20246

Universitätsklinikum Hamburg-Eppendorf, Hamburg

22021

Memorial Healthcare System, Hollywood

23502

Virginia Oncology Associates, Norfolk

24382

Blue Ridge Cancer Care, Christiansburg

26100

ASST di Cremona, Cremona

27310

Gaziantep Univ. Tip Fakultesi Tibbi Onkoloji Bilim Dali, Gaziantep

28040

Hospital Clínico San Carlos, Madrid

28046

Hospital La Paz, Madrid

29010

Hospital Regional Universitario de Málaga, Málaga

Hospital Virgen de la Victoria, Málaga

29303

Spartanburg Regional Medical Center, Spartanburg

32024

Cancer Care of North Florida, PA, Lake City

33076

INS Bergonié, Bordeaux

33100

A. O. S. Maria della Misericordia, Udine

33486

Boca Raton Reginl Hospital-Lynn Cancer Institute, Boca Raton

35033

HOP de Rennes, Pneumo, Rennes, Rennes

35100

Ege Universitesi Tip Fakultesi Tibbi Onkoloji Bilim Dali, Izmir

35120

Dr.Suat Seren EAH, Izmir

35128

Istituto Oncologico Veneto IRCCS, Padua

38501

Cancer Center of Cookeville Regional Medical Center, Cookeville

40139

P.O. Bellaria IRCCS Istituto delle scienze Neurologiche di Bologna, Bologna

40202

University of Louisville, Louisville

41110

University Hospital of Larisa, Oncology Clinic, Larissa

41221

General Hospital of Larissa, Larissa

43100

Azienda Ospedaliera di Parma, Parma

43201

The Ohio State University Wexner Medical Center, Columbus

43219

Mid Ohio Oncology/Hematology, Inc, Columbus

44195

Cleveland Clinic, Cleveland

45147

Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH, Essen

46010

Hospital Clínico de Valencia, Valencia

48149

Universitätsklinikum Münster, Münster

48201

Karmanos Cancer Institute, Detroit

48431

Mathias-Spital Rheine, Rheine

50009

Hospital Clínico Universitario Lozano Blesa, Zaragoza

50080

Centro Hemato-Oncologico Privado de Toluca S.A. de C.V., Toluca

51056

INS Jean Godinot, Onco, Reims, Reims

56126

Azienda Ospedaliera Universitaria Pisana, Pisa

56429

"General Hospital G. Papageorgiou", Thessaloniki

57100

Spedali Riuniti di Livorno, Livorno

58675

Lungenklinik Hemer, Hemer

59020

CTR Oscar Lambret, Cancéro, Lille, Lille

59037

HOP Calmette, Lille

59101

Billings Clinic Cancer Center, Billings

60076

Orchard Healthcare Research Inc, Skokie

60590

Universitätsklinikum Frankfurt, Frankfurt am Main

60714

Illinois Cancer Specialists, Niles

63003

HOP Gabriel-Montpied, Clermont-Ferrand

63110

Washington University School of Medicine, St Louis

64000

Hospital y Clínica OCA S. A. de C. V., Monterrey

67091

HOP Civil, Strasbourg

68070

HOP de Mulhouse, Onco, Mulhouse, Mulhouse

68167

Universitätsklinikum Mannheim GmbH, Mannheim

70072

West Jefferson General Hospital and Cancer Clinic, Marrero

71110

University General Hospital of Heraklion, Heraklion

72037

HOP Le Mans, Le Mans

73730

Klinikum Esslingen GmbH, Esslingen am Neckar

75014

HOP Cochin, Paris

75230

HOP Val de Grâce, Onco, Paris, Paris

75460

Paris Cancer Center (PCC), Texas Oncology, Paris

78229

Cancer Therapy and Research at UTHSCSA, San Antonio

79106

Universitätsklinikum Freiburg, Freiburg im Breisgau

80131

Istituto Nazionale Tumori Fondazione Pascale, Napoli

85224

Ironwood Cancer and Research Centers, Chandler

92093

University of California, La Jolla

92151

HOP Foch, Suresnes

94010

HOP de Creteil, Pneumo, Creteil, Créteil

94805

INS Gustave Roussy, Villejuif

95816

Sutter Medical Group, Sacramento

97227

Kaiser Permanente Northwest, Portland

98039

Ospedale San Vincenzo, Taormina (ME)

99437

Zentralklinik Bad Berka GmbH, Bad Berka

100036

Beijing Cancer Hospital, Beijing

100730

Beijing Hospital, Beijing

130021

First Hospital of Jilin University, Changchun

169610

National Cancer Centre, Singapore

200030

Shanghai Chest Hospital, Shanghai

200433

Shanghai Pulmonary Hospital, Shanghai

210002

the 81th Hospital of PLA, Nanjing

210009

Jiangsu Cancer Hospital, Nanjing

308433

Johns Hopkins Singapore International Medical Centre, Singapore

388325

M.S. Patel Cancer Hospital, Karamsad

400012

Tata Memorial Hospital, Mumbai

410008

Xiangya Hospital, Central South University, Changsha

411001

Ruby Hall Clinic, Pune

510060

Sun Yat-Sen University Cancer Center, Guangzhou

560052

Vikram Hospital, Bangalore

600031

V S Hospital, Chennai

600100

Dr. Kamakshi Memorial Hospital, Chennai

600116

Sri Ramachandra Medical College & Research Institute, Chennai

700053

B. P .Poddar Hospital & Medical Research Ltd., Kolkata, West Bengal

1720421

Centro Oncologico Antofagasta, Antofagasta

7501088

Instituto de Terapias Oncologicas Providencia, Providencia, Santiago

7630457

Orlandi Oncologia, Vitacura

8420383

Centro Internacional de Estudios Clinicos - CIEC, Recoleta, Santiago de Chile

01805

Lahey Clinic, Burlington

01841

Commonwealth Hematology-Oncology, PC, Lawrence

05401

Fletcher Allen Health Care, Burlington

C1426ANZ

Instituto Medico Especializado Alexander Fleming, Ciudad Autonoma de Bs As

X5000HXL

Instituto Oncologico de Cordoba, Córdoba

X5002AOQ

Clínica Colombo S.A., Córdoba

S2000KZE

Centro Oncologico de Rosario, Rosario

T4000GTB

Centro Oncologico CAIPO, San Miguel de Tucumán

V3V 1Z2

BC Cancer Agency - Fraser Valley Centre, Surrey

K7L 5P9

Kingston General Hospital, Kingston

K1H 8L6

The Ottawa Hospital, Ottawa

H3A 1A1

Royal Victoria Hospital, Montreal

H3G 1A4

Montreal General Hospital - McGill University Health Centre, Montreal

49 933

HOP d'Angers, Angers

02303

HOP de Chauny, Chauny

02321

HOP Saint Quentin, Onco, Saint Quentin, Saint-Quentin

Dublin

St James's Hospital, Dublin

5223 GZ

Jeroen Bosch Ziekenhuis-Hertogenbosch, 's-Hertogenbosch

6815 AD

Rijnstate Hospital, Arnhem

4818 CK

Amphia Ziekenhuis, Breda

5623 EJ

Catharina Ziekenhuis, Eindhoven

6229 HX

METC Academisch Ziekenhuis Maastricht/Universiteit van Maastricht, Maastricht

3435 CM

St. Antonius ziekenhuis, locatie Nieuwegein, Nieuwegein

3015 CD

Erasmus Medisch Centrum, Rotterdam

3041-801

CHUC - Centro Hospitalar e Universitário de Coimbra, EPE, Coimbra

1064-035

CHLN, EPE - Hospital de Santa Maria, Lisbon

1099-023

IPO Lisboa Francisco Gentil, EPE, Lisbon

4200-072

IPO Porto Francisco Gentil, EPE, Porto

4200-319

Centro Hospitalar São João,EPE, Porto

4434-502

Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia

361-711

Chungbuk National University Hospital, Cheongju-si

405-760

Gachon University Gil Medical Center, Incheon

660-702

Gyeongsang National University Hospital, Jinju

05505

Asan Medical Center, Seoul

130-710

Samsung Medical Center, Seoul

137-701

The Catholic University of Korea, Seoul St.Mary's Hospital, Seoul

442-723

The Catholic University of Korea, St.Vincent's Hospital, Suwon

682-714

Ulsan University Hospital, Ulsan

08035

Hospital Vall d'Hebron, Barcelona

08041

Hospital Santa Creu i Sant Pau, Barcelona

07070

Akdeniz Universitesi Tip Fakultesi, Antalya

Unknown

Dicle Universitesi Tip Fakultesi, Diyarbakır

Kartal Egitim Ve Arastirma Hastanesi, Istanbul

Yedikule Gog. Hst. EAH, Istanbul

B15 2TH

Queen Elizabeth Hospital, Birmingham

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

HG2 7SX

Harrogate District Hospital, Harrogate

NW3 2QG

Royal Free Hospital, London

SW3 6JJ

The Royal Marsden Hospital, London

ME16 9QQ

Maidstone Hospital, Kent Oncology Centre, Maidstone

NG5 1PB

Nottingham City Hospital, Nottingham

YO12 6QL

Scarborough Hospital, Scarborough

SM2 5PT

The Royal Marsden Hospital, Sutton

Sponsors
All Listed Sponsors
lead

Boehringer Ingelheim

INDUSTRY