Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

282

Participants

Timeline

Start Date

March 1, 2012

Primary Completion Date

June 1, 2015

Study Completion Date

March 19, 2026

Conditions
Chronic Myelomonocytic LeukemiaChronic Myelomonocytic Leukemia-1Chronic Myelomonocytic Leukemia-2Myelodysplastic SyndromeMyelodysplastic Syndrome With Excess BlastsMyelodysplastic Syndrome With Excess Blasts-1Myelodysplastic Syndrome/Acute Myeloid Leukemia
Interventions
DRUG

Azacitidine

Given SC or IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Lenalidomide

Given PO

DRUG

Vorinostat

Given PO

Trial Locations (294)

10065

NYP/Weill Cornell Medical Center, New York

10461

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

11030

North Shore University Hospital, Manhasset

11042

Northwell Health/Center for Advanced Medicine, Lake Success

11501

NYU Langone Hospital - Long Island, Mineola

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17015

Carlisle Regional Cancer Center, Carlisle

17822

Geisinger Medical Center, Danville

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

18840

Guthrie Medical Group PC-Robert Packer Hospital, Sayre

18901

Doylestown Hospital, Doylestown

19611

Reading Hospital, West Reading

19718

Christiana Care Health System-Christiana Hospital, Newark

19958

Beebe Medical Center, Lewes

20016

Sibley Memorial Hospital, Washington D.C.

20422

Veterans Affairs Medical Center -Washington DC, Washington D.C.

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

21921

Christiana Care - Union Hospital, Elkton

24112

Sovah Health Martinsville, Martinsville

26506

West Virginia University Healthcare, Morgantown

27104

Southeast Clinical Oncology Research Consortium NCORP, Winston-Salem

27203

Randolph Hospital, Asheboro

27320

Annie Penn Memorial Hospital, Reidsville

27403

Cone Health Cancer Center, Greensboro

27534

Wayne Memorial Hospital, Goldsboro

28374

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

28501

ECU Health Oncology Kinston, Kinston

28677

Iredell Memorial Hospital, Statesville

28791

Margaret R Pardee Memorial Hospital, Hendersonville

29303

Spartanburg Medical Center, Spartanburg

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29401

Roper Hospital, Charleston

29601

Saint Francis Hospital, Greenville

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29672

Prisma Health Cancer Institute - Seneca, Seneca

30912

Augusta University Medical Center, Augusta

32610

University of Florida Health Science Center - Gainesville, Gainesville

32803

AdventHealth Orlando, Orlando

33140

Mount Sinai Medical Center, Miami Beach

33458

Jupiter Medical Center, Jupiter

35233

University of Alabama at Birmingham Cancer Center, Birmingham

36688

University of South Alabama Mitchell Cancer Institute, Mobile

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37916

Thompson Cancer Survival Center, Knoxville

39216

University of Mississippi Medical Center, Jackson

40536

University of Kentucky/Markey Cancer Center, Lexington

43055

Licking Memorial Hospital, Newark

43081

Saint Ann's Hospital, Westerville

43214

Riverside Methodist Hospital, Columbus

43215

Columbus NCI Community Oncology Research Program, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43560

ProMedica Flower Hospital, Sylvania

43614

University of Toledo, Toledo

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

Cleveland Clinic Cancer Center Beachwood, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44129

University Hospitals Parma Medical Center, Parma

44131

Cleveland Clinic Cancer Center Independence, Independence

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44195

Cleveland Clinic Foundation, Cleveland

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

44870

North Coast Cancer Care, Sandusky

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45409

Miami Valley Hospital, Dayton

45504

Springfield Regional Medical Center, Springfield

45750

Marietta Memorial Hospital, Marietta

46410

Premier Oncology Hematology Associates, Merrillville

48060

Lake Huron Medical Center, Port Huron

48093

Henry Ford Health Warren Hospital, Warren

48106

Michigan Cancer Research Consortium NCORP, Ann Arbor

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48236

Henry Ford Health Saint John Hospital, Detroit

49007

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49444

Trinity Health Muskegon Hospital, Muskegon

49503

Cancer Research Consortium of West Michigan NCORP, Grand Rapids

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

49829

OSF Saint Francis Hospital and Medical Group, Escanaba

50010

McFarland Clinic - Ames, Ames

50702

MercyOne Waterloo Cancer Center, Waterloo

51101

Siouxland Regional Cancer Center, Sioux City

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

Aurora Medical Center in Summit, Summit

53188

ProHealth Waukesha Memorial Hospital, Waukesha

53226

Medical College of Wisconsin, Milwaukee

Aurora Cancer Care-Milwaukee West, Wauwatosa

53548

Mercyhealth Hospital and Cancer Center - Janesville, Janesville

53715

SSM Health Dean Medical Group - South Madison Campus, Madison

54143

Aurora Bay Area Medical Group-Marinette, Marinette

Bay Area Medical Center, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54311

Aurora BayCare Medical Center, Green Bay

54449

Marshfield Medical Center-Marshfield, Marshfield

Marshfield Medical Center, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54481

Aspirus Cancer Care - Stevens Point, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54501

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

54548

Marshfield Medical Center - Minocqua, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

HSHS Sacred Heart Hospital, Eau Claire

Marshfield Clinic Cancer Center at Sacred Heart, Eau Claire

54729

Marshfield Clinic-Chippewa Center, Chippewa Falls

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55082

Lakeview Hospital, Stillwater

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55417

Minneapolis VA Medical Center, Minneapolis

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55805

Essentia Health Cancer Center, Duluth

55905

Mayo Clinic in Rochester, Rochester

56201

Rice Memorial Hospital, Willmar

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

56601

Sanford Joe Lueken Cancer Center, Bemidji

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

57701

Rapid City Regional Hospital, Rapid City

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Mid Dakota Clinic, Bismarck

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59715

Bozeman Health Deaconess Hospital, Bozeman

60153

Loyola University Medical Center, Maywood

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60611

Hematology and Oncology Associates, Chicago

Northwestern University, Chicago

60612

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61104

Swedish American Hospital, Rockford

61114

UW Health Carbone Cancer Center Rockford, Rockford

61265

Trinity Medical Center, Moline

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61462

Illinois CancerCare-Monmouth, Monmouth

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61761

Illinois CancerCare-Community Cancer Center, Normal

61801

Carle Cancer Center, Urbana

62321

Illinois CancerCare-Carthage, Carthage

62526

Decatur Memorial Hospital, Decatur

Heartland Cancer Research NCORP, Decatur

62644

Illinois CancerCare-Havana, Havana

62781

Springfield Memorial Hospital, Springfield

63141

Mercy Hospital Saint Louis, St Louis

Saint Louis-Cape Girardeau CCOP, St Louis

63703

Saint Francis Medical Center, Cape Girardeau

64111

Saint Luke's Hospital of Kansas City, Kansas City

65201

Veterans Administration, Columbia

65212

MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia

66160

University of Kansas Cancer Center, Kansas City

66208

Kansas City NCI Community Oncology Research Program, Prairie Village

66606

Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka

70121

Ochsner Medical Center Jefferson, New Orleans

70809

Ochsner Health Center-Summa, Baton Rouge

71103

LSU Health Sciences Center at Shreveport, Shreveport

72205

John L McClellan Memorial Veterans Hospital, Little Rock

73071

Cancer Care Associates-Norman, Norman

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

79106

The Don and Sybil Harrington Cancer Center, Amarillo

80012

The Medical Center of Aurora, Aurora

80045

UCHealth University of Colorado Hospital, Aurora

80111

Rocky Mountain Cancer Centers-Greenwood Village, Greenwood Village

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Swedish Medical Center, Englewood

80122

AdventHealth Littleton, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

Sky Ridge Medical Center, Lone Tree

80138

AdventHealth Parker, Parker

Rocky Mountain Cancer Centers-Parker, Parker

80210

AdventHealth Porter, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

Saint Joseph Hospital - Cancer Centers of Colorado, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

Rose Medical Center, Denver

80222

Western States Cancer Research NCORP, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80303

Boulder Community Foothills Hospital, Boulder

80401

Mountain Blue Cancer Care Center, Golden

Intermountain Health Lutheran Hospital, Wheat Ridge

80501

Longmont United Hospital, Longmont

80524

Poudre Valley Hospital, Fort Collins

80539

Banner McKee Medical Center, Loveland

80631

Banner North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81301

Mercy Medical Center, Durango

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85259

Mayo Clinic in Arizona, Scottsdale

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

87106

University of New Mexico Cancer Center, Albuquerque

87110

Presbyterian Kaseman Hospital, Albuquerque

90033

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

94080

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

94304

Stanford Cancer Institute Palo Alto, Palo Alto

94531

Kaiser Permanente-Deer Valley Medical Center, Antioch

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

94801

Kaiser Permanente-Richmond, Richmond

94903

Kaiser Permanente-San Rafael, San Rafael

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

Sutter Pacific Medical Foundation, Santa Rosa

95823

Kaiser Permanente-South Sacramento, Sacramento

95825

Kaiser Permanente Sacramento Medical Center, Sacramento

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Queen's Cancer Center - Kuakini, Honolulu

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

97030

Legacy Mount Hood Medical Center, Gresham

97045

Providence Willamette Falls Medical Center, Oregon City

97132

Providence Newberg Medical Center, Newberg

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

97213

Providence Portland Medical Center, Portland

97222

Providence Milwaukie Hospital, Milwaukie

97225

Providence Saint Vincent Medical Center, Portland

98664

PeaceHealth Southwest Medical Center, Vancouver

06030

University of Connecticut, Farmington

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06050

The Hospital of Central Connecticut, New Britain

04401

Eastern Maine Medical Center, Bangor

02114

Massachusetts General Hospital Cancer Center, Boston

02215

Dana-Farber Cancer Institute, Boston

02135

Dana-Farber Cancer Institute at Boston Medical Center - Brighton, Brighton

01199

Baystate Medical Center, Springfield

01655

UMass Memorial Medical Center - University Campus, Worcester

08103

Cooper Hospital University Medical Center, Camden

17033-0850

Penn State Milton S Hershey Medical Center, Hershey

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

54301-3526

Green Bay Oncology at Saint Vincent Hospital, Green Bay

T2N 5G2

Arthur J E Child Comprehensive Cancer Centre, Calgary

V5Z 3P1

Clinical Research Unit at Vancouver Coastal Health Authority, Vancouver

R3E 0V9

CancerCare Manitoba, Winnipeg

E1C 6Z8

The Moncton Hospital, Moncton

E2L 4L2

Atlantic Health Sciences Corporation-Saint John Regional Hospital, Saint John

B3H 2Y9

QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

M4N 3M5

Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

J4V 2H1

CSSS Champlain-Charles Le Moyne, Greenfield Park

H2W 1S6

McGill University Department of Oncology, Montreal

H3H 2R9

The Research Institute of the McGill University Health Centre (MUHC), Montreal

S4T 7T1

Allan Blair Cancer Centre, Regina

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH